Search Results - therapy

39 Results Sort By:
RNA-Targeted Small Molecules as Potential Antiviral Therapy (HIV, SARS etc)
Brief Description: A high error rate of HIV -I reverse transcriptase coupled with a fast replication cycle associated with HIV -1 favors rapid development and selection of drug resistant strains. Therefore, identification of small molecules capable of inhibiting viral components necessary for HIV -1 proliferation continues to be of great importance....
Published: 5/7/2024   |   Inventor(s): Benjamin Miller, Brian Mcnaughton, Peter Gareiss, Joseph Wedekind
Keywords(s): AIDS, HIV, Small Molecule, Therapy
Category(s): Therapeutic
Protease Activated Cytokines as Anti-Cancer Therapy
A novel therapy method for delivering localized anti-cancer responses without adverse body-wide side effects. Problem Solved by the Technology Despite remarkable success at identifying tumor-associated antigens (TAA), generating effective anti-tumor immune response has not been successful at eliminating tumors. Systemically administered active drugs...
Published: 5/7/2024   |   Inventor(s): John Frelinger, John Puskas, Baek Kim, Mark Sullivan
Keywords(s): Cancer, Immunotherapy, Oncology, Therapy
Category(s): Therapeutic
Copyright: Artificial Intelligence Augmented Expressive Writing Tool (Case No. 2023-084)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel software tool that leverages artificial intelligence to assist with a user’s expressive writing process. Background: With the recent rise in mental health diagnoses and awareness, there is a higher demand for mental health services which...
Published: 8/20/2024   |   Inventor(s): Xiang Chen, Ruolin Wang
Keywords(s): active learning, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence augmentation, Artificial Neural Network, clinical mental health, design software, expressive writing, human-centered computing, intervention, Machine Learning, Mental health, Software, Software & Algorithms, Software Development Tools, talk therapy, therapy
Category(s): Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning
PIM-Targeted PROTACs
Abstract: Proviral Integration for the Moloney murine leukemia virus (PIM) kinases are overexpressed in many solid cancers – including prostate, breast, colon, endometrial, gastric and pancreatic. High of PIM1 expression is predictive of poor survival in multiple cancer types. While several selective pan-PIM inhibitors were developed and tested in clinical...
Published: 4/8/2024   |   Inventor(s): John Brognard, Rolf Swenson, Pedro Torres-Ayuso, Venkatareddy Sabbasani, Dawid Mehlich, Noel Warfel
Keywords(s): anti-cancer, Brognard, Chemotherapy Resistance, Kinase, PIM, PIM kinase-targeting proteolysis-targeting chimeras, PROTACs, solid tumors, Swenson, THERAPY
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
IL7Rα-Specific Antibody for Treating Acute Lymphoblastic Leukemia (ALL)
Abstract: Acute lymphoblastic leukemia (ALL) is the most common cancer in children with approximately 3,250 new cases occurring per year in the United States. About 20% of cases are refractory to current treatment protocols and there is a desperate need for targeted therapies that do not result in adverse side effects such as cognitive impairment.  The...
Published: 4/8/2024   |   Inventor(s): Scott Durum, Julie Hixon, Wenqing Li, Scotch Walsh, Lila Kashi
Keywords(s): Acute lymphoblastic leukemia (ALL), ANTIBODY, Antibody-Dependent Cellular Cytotoxicity (ADCC), Autoimmunity, CANCER, DIABETES, Durum, Interleukin-7 receptor-α (IL-7Rα), Multiple sclerosis, personalized medicine, Targeted therapy, THERAPY, TRANSPLANTATION
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration
Retroviral Vector Packaging Cell Lines and Purification Methods for Gene Therapy
This invention relates to a novel gammaretroviral vector packaging cell line and a method of producing gammaretroviral vectors suitable for gene therapy. The described vectors may contain the gibbon ape leukemia virus (GALV) envelope with a CD11D8 epitope tag enabling their purification on a monoclonal antibody conjugated column. These vectors have...
Published: 7/25/2024   |   Inventor(s): Wenqin Xu, Maribeth Eiden
Keywords(s): Cell, Gammaretroviral, GB2A2X, GB2CXX, Genetic, Line, Listed LPM Maddox as of 4/15/2015, Method, Novel, Packaging, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Producing, Suitable, THERAPY, Vector, vectors, VPXXXX, WIXXXX, WJXXXX, XEXXXX
Category(s): TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, Application > Research Materials
Serum Protein Biomarkers that Predict the Response to Liver Directed Therapy in Methymalonic Acidemia (MMA) and Propionic Acidemia (PA)
Isolated Methylmalonic Acidemia (MMA) comprises a relatively common and heterogeneous group of inborn errors of metabolism. The most common cause of isolated MMA is genetic deficiency of the enzyme methylmalonyl-coA mutase (MUT), which, unfortunately for the affected patients, is also the most clinically severe. NHGRI scientist have discovered biomarkers...
Published: 7/25/2024   |   Inventor(s): Eirini (Irini) Manoli, Charles Venditti
Keywords(s): Acidemia, Biomarkers, Directed, liver, Methymalonic, MMA, PREDICT, Protein, RESPONSE, SERUM, That, THERAPY, VPXXXX, WBXXXX, WIXXXX, XCXXXX, XEXXXX
Category(s): Application > Diagnostics, TherapeuticArea > Ophthalmology, Application > Research Materials, TherapeuticArea > Cardiology, TherapeuticArea > Oncology, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Infectious Disease
Non-invasive Isotopic Biomarkers that Predict the Response to Liver Directed Therapy in Methymalonic Acidemia (MMA) and Propionic Acidemia (PA)
Isolated Methylmalonic Acidemia (MMA) comprises a relatively common and heterogeneous group of inborn errors of metabolism. The most common cause of isolated MMA is genetic deficiency of the enzyme methylmalonyl-coA mutase (MUT), which, unfortunately for the affected patients, is also the most clinically severe. NHGRI scientist have invented a series...
Published: 7/25/2024   |   Inventor(s): Eirini (Irini) Manoli, Charles Venditti
Keywords(s): Acidemia, Biomarkers, Directed, ISOTOPIC, liver, Methymalonic, MMA, NON-INVASIVE, PREDICT, RESPONSE, That, THERAPY, VPXXXX, WFXXXX, WIXXXX, XCXXXX
Category(s): Application > Occupational Safety and Health, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Dental, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology
Gene Therapy for Cobalamin C Deficiency (cblC) with Viable Mouse Models
Cobalamin C deficiency (cblC) is the most common inborn error of intracellular cobalamin metabolism and is caused by mutations in MMACHC, a gene responsible for processing and trafficking dependent enzymes: intracellular cobalamin, resulting in elevated methylmalonic acid and homocysteine and methionine deficiency. Disease manifestations include growth...
Published: 7/25/2024   |   Inventor(s): Jennifer Sloan, Charles Venditti
Keywords(s): C, cblC, Cobalamin, DEFICIENCY, Gene, THERAPY, VDXXXX, VEXXXX, VPXXXX, WIXXXX, WJXXXX, XEXXXX
Category(s): TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, TherapeuticArea > Neurology, TherapeuticArea > Infectious Disease, Application > Research Materials
Development of a Therapy for the Treatment of Zellweger Spectrum Disorder
This technology includes a method for selecting a therapeutic effective amount of one of two compounds (including naltriben and naltrin) for the treatment of Zellweger Spectrum Disorder (ZSD), or any disease associated with peroxisome dysfunction. The compounds were identified using a cell-image based high-content screening (HCS) assay to identify small...
Published: 7/25/2024   |   Inventor(s): Patricia Dranchak, James Inglese
Keywords(s): DEVELOP, DISORDER, Spectrum, THERAPY, TOOLS, treatment, VEXXXX, WIXXXX, WKXXXX, Zellweger
Category(s): TherapeuticArea > Neurology, Application > Therapeutics, Application > Research Materials
1 2 3 4