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Nisin Lan
t
ibiotic Mitigates Brain Microbiome Dysbiosis and Alzheimer’s Disease-Like Neuroinflammation (UCLA Case No. 2024-096)
Researchers led by Professor Yvonne Kapila in
t
he UCLA School of Dentistry have developed a technology that harnesses nisin, a well-characterized probiotic lantibiotic bacteriocin, as a novel therapeutic to address brain microbiome dysbiosis and Alzheimer’s disease (AD)-like neuroinflammation driven by periodontal disease. By targeting the microbial...
Published: 9/13/2025
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Inventor(s):
Yvonne Kapila
Keywords(s):
Category(s):
T
herapeutics > CNS and Neurology
POLQ as a Media
t
or of Radioresistance in Prostate Cancer (UCLA Case No. 2024-068)
Please con
t
act UCLA Technology Development Group for more information. KEYWORDS: cancer biology, cancer therapy resistance, molecular oncology, drug discovery, radiosensitization, radioresistance mechanisms, predictive biomarkers, prostate cancer
Published: 9/13/2025
|
Inventor(s):
Paul Bou
t
ros
Keywords(s):
Category(s):
T
herapeutics > Oncology
,
Diagnos
t
ic Markers
Cohesive CLEM,
T
EM, FEBSEM System for MicroED and Cryo-EM Applications (Case No. 2025-010)
Summary UCLA researchers have developed a cohesive elec
t
ron microscope system that uniquely integrates transmission electron microscopy (TEM), fluorescence microscopy, and focused ion beam scanning electron microscopy (FIB-SEM) into a single automated column. The platform supports both cryogenic and room-temperature workflows, enabling fully automated...
Published: 9/12/2025
|
Inventor(s):
T
amir Gonen
,
Michael Mar
t
ynowycz
Keywords(s):
Category(s):
Life Science Research
T
ools
,
Life Science Research
T
ools > Microscopy And Imaging
,
Life Science Research
T
ools > Research Methods
,
Medical Devices
,
Medical Devices > Medical Imaging
,
Pla
t
forms
Discre
t
e Approximation of Permanent Magnet Arrays (Case No. 2025-203)
Summary UCLA researchers have developed Discre
t
e-MAG, a discrete magnetic actuation / magnetics platform that delivers precise, programmable magnetic field manipulation at small scales. The system aims to control magnetic particles or micro-devices discretely for applications in sensing, actuation, imaging, or biological interfacing. Background Magnetic...
Published: 9/12/2025
|
Inventor(s):
T
yler Clites
,
He Kai Lim
,
Will Flanagan
,
Cameron
T
aylor
Keywords(s):
Category(s):
Ma
t
erials
,
Ma
t
erials > Functional Materials
,
Medical Devices
,
Mechanical
,
Mechanical > Robo
t
ics
,
Pla
t
forms
,
Pla
t
forms > Drug Delivery
,
Medical Devices > Medical Imaging
,
Life Science Research
T
ools
,
Life Science Research
T
ools > Research Methods
Mul
t
imeter-Wave Acoustic Resonators (Case No. 2025-167)
Summary Researchers a
t
the University of Texas System have developed multimeter-wave acoustic resonators using thin-film piezoelectric materials such as lithium niobate / lithium tantalate or aluminum nitride / scandium aluminum nitride, in combination with intermediate buffer layers. These resonators support higher-order antisymmetric bulk acoustic...
Published: 9/12/2025
|
Inventor(s):
Mark Goorsky
,
Ruochen Lu
,
Jack Kramer
,
Sinwoo Cho
,
Omar Barrera
Keywords(s):
Category(s):
Elec
t
rical
,
Elec
t
rical > Electronics & Semiconductors
,
Elec
t
rical > Signal Processing
,
Op
t
ics & Photonics
Me
t
hods of Dealkenylative Amination and Azidation (UCLA Case No. 2024-032)
UCLA researchers led by Professor Ohyun Kwon have developed a
t
oolkit for organic synthesis, providing chemists with a robust, selective, and practical solution for the construction of amine and azide functionalities via innovative dealkenylative strategies, opening new avenues in drug discovery and complex molecule assembly. The dealkenylative amination...
Published: 9/12/2025
|
Inventor(s):
Ohyun Kwon
Keywords(s):
Category(s):
Pla
t
forms
,
Life Science Research
T
ools
S
t
ructure-Based Design of Antisense Oligonucleotide Drugs (UCLA Case No. 2020-916)
UCLA researchers led by Professor Feng Guo have developed a nex
t
-generation platform for designing antisense oligonucleotide (ASO) therapeutics using RNA structure as a blueprint, achieving enhanced specificity, efficacy, and versatility for the treatment of a wide spectrum of genetic and infectious diseases. INNOVATION: UCLA researchers in the Department...
Published: 9/12/2025
|
Inventor(s):
Feng Guo
,
Vai
t
hilingaraja Arumugaswami
Keywords(s):
Category(s):
Pla
t
forms
,
T
herapeutics > Infectious Diseases
,
T
herapeutics > Genetic Diseases
Hess Screen
T
est Chart Digitalization Tool (Case No. 2024-164)
Summary UCLA researchers have developed a sof
t
ware-based digitizer for Hess Screen Test (HST) charts that automates extraction of gaze misalignment measurements across the visual field, converting paper charts into precise numerical eye-angle data. The system is faster, more repeatable, and more scalable than manual annotation. IOVS Background The...
Published: 9/12/2025
|
Inventor(s):
Qi Wei
,
Andrew Ryan
,
Joseph Demer
Keywords(s):
Category(s):
Sof
t
ware & Algorithms
,
Sof
t
ware & Algorithms > Digital Health
,
Sof
t
ware & Algorithms > Image Processing
,
Medical Devices
,
Medical Devices > Medical Imaging
,
Medical Devices > Moni
t
oring And Recording Systems
Self-Assembling
T
etrahedral Protein Cages Based on Machine Learning Algorithms (UCLA Case No. 2023-300)
Please con
t
act our office for more information regarding this innovation. See also Technology -2020-922 A Universal Designed Protein Cage for Sensing and Responding to Any Other Protein Molecule Related publications (by the inventors only): Gladkov N, Scott EA, Meador K, Lee EJ, Laganowsky AD, Yeates TO, Castells-Graells R. Design of a symmetry-broken...
Published: 9/12/2025
|
Inventor(s):
T
odd Yeates
Keywords(s):
Category(s):
Medical Devices
,
Pla
t
forms > Drug Delivery
Cons
t
ruction of Low-Rate LDPC Codes From Rate-½ CCSDS Standard LDPC Codes (Case No. 2025-243)
Reference: UCLA Case No. 2025-243. Please reach ou
t
to our office for more information.
Published: 9/12/2025
|
Inventor(s):
Richard Wesel
,
Semira Galijasevic
,
Linfang Wang
,
Jon Hamkins
,
Dariush Divsalar
Keywords(s):
Category(s):
Sof
t
ware & Algorithms
,
Sof
t
ware & Algorithms > Communication & Networking
,
Sof
t
ware & Algorithms > Security & Privacy
,
Elec
t
rical
,
Elec
t
rical > Signal Processing
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