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17139
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ID
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Sulfonyl-
t
riazole activators for cell-selective glycolysis enhancement in cancer and Parkinson’s disease
Background Cellular me
t
abolism is a central regulator of immune cell function and neuronal survival, making it a promising therapeutic target in both cancer and neurodegenerative disease. In solid tumors, tumor-infiltrating lymphocytes (TILs) frequently succumb to metabolic exhaustion due to the nutrient-depleted and immunosuppressive microenvironment,...
Published: 1/27/2026
|
Inventor(s):
Ku-Lung Hsu
,
Xiaoding Jiang
,
Xiaolu Cambronne
Keywords(s):
Category(s):
Life sciences >
T
herapeutics > Formulation
,
Life sciences >
T
herapeutics > Drug discovery
Microneedle array coa
t
ing technology for enhanced stability and targeted delivery of mRNA and biologics
A microneedle-based sys
t
em uses cryogenically pre-cooled needles coated via thin-film freeze-coating to preserve mRNA stability, enabling efficient, multi-therapeutic intradermal delivery of temperature-sensitive drugs. Background The field of advanced drug delivery systems has grown substantially as the biomedical industry grapples with the complexities...
Published: 1/27/2026
|
Inventor(s):
Zhengrong Cui
,
Michael Sandoval
,
Rober
t
Williams
,
Drew Weissman
,
Qin Li
Keywords(s):
Category(s):
Life sciences >
T
herapeutics > Drug discovery
A microneedle-based resonan
t
sensor system for continuous, wireless monitoring of wound and physiological states
T
his technology uses gold-coated microneedles and wireless sensors to directly sample wound fluid, detecting infection and other changes in real time. Data is analyzed with machine learning and sent to clinicians for early, continuous wound monitoring. Background Wound monitoring is a critical aspect of healthcare, especially for patients recovering...
Published: 1/27/2026
|
Inventor(s):
James Clarke
,
Miles Massidda
,
Joseph Schmid
t
,
Cris
t
ina Checka
,
Sco
t
t Alpard
Keywords(s):
Category(s):
Life sciences > Medical
t
echnology > Medical devices
Misalignmen
t
Resilient Diffractive Optical Networks (Case No. 2020-885)
Summary: UCLA researchers in
t
he Department of Electrical and Computer Engineering have developed and experimentally validated a comprehensive training scheme that greatly enhances the robustness of diffractive networks to 3D misalignments and fabrication tolerances in their physical implementation. Background: As an optical machine learning framework,...
Published: 1/28/2026
|
Inventor(s):
Aydogan Ozcan
Keywords(s):
Op
t
ical Communication
,
Op
t
ical computing
,
op
t
ical implementation
,
Op
t
ical networks
,
op
t
ical processor
Category(s):
Sof
t
ware & Algorithms
,
Sof
t
ware & Algorithms > Image Processing
,
Op
t
ics & Photonics
An
t
ibody compositions for improving detection and treatment of
Bacillus anthracis
infections
T
his technology uses specially designed antibodies with enhanced ability to detect or treat Bacillus anthracis infections, improving both diagnosis and therapy for anthrax. Background Bacillus anthracis, the causative agent of anthrax, is a highly virulent bacterium that poses significant threats to both public health and national security. Anthrax...
Published: 1/27/2026
|
Inventor(s):
George Georgiou
,
Bren
t
Iverson
,
Barre
t
t Harvey
Keywords(s):
Category(s):
Life sciences > Immunology
,
Life sciences >
T
herapeutics
Engineered enzyme
t
herapy for targeted reduction of plasma homocysteine in metabolic disorders
T
his technology is a specially engineered human enzyme, modified and PEGylated to break down excess homocysteine in the blood, offering a new treatment for homocystinuria and hyperhomocysteinemia with improved effectiveness and dosing flexibility. Background Homocystinuria and hyperhomocysteinemia are metabolic disorders characterized by elevated...
Published: 1/27/2026
|
Inventor(s):
Sco
t
t Rowlinson
,
Chris
t
opher Daige
,
Leslie Sloan
Keywords(s):
Category(s):
Life sciences >
T
herapeutics > Small molecule
Regula
t
ed Gene Expression During Differentiation of Mature T Cells (UCLA Case No. 2022-147)
UCLA researchers from
t
he Department of Pathology & Laboratory Medicine have developed a process to genetically modify stem cells to express transgenes in a regulated, stage-specific manner, avoiding the negative consequences of transgene expression during T cell development. Contact UCLA Technology Development Group for more information.
Published: 1/27/2026
|
Inventor(s):
Gay Crooks
,
Donald Kohn
Keywords(s):
Category(s):
T
herapeutics > Gene Therapy And Editing
,
T
herapeutics > Stem Cells And Regenerative Medicine
,
T
herapeutics > Oncology
,
T
herapeutics > Immunology And Immunotherapy
,
T
herapeutics > Inflammation And Inflammatory Diseases
Enhancing
T
Cell Production in Vitro From Stem and Progenitor Cells (UCLA Case No. 2022-257)
UCLA researchers from
t
he Department of Pathology and Laboratory Medicine have developed an innovative differentiation method to increase T cell production for T cell immunotherapy. Contact UCLA Technology Development Group for more information.
Published: 1/27/2026
|
Inventor(s):
Gay Crooks
,
Chris
t
opher Seet
Keywords(s):
Category(s):
T
herapeutics > Oncology
,
T
herapeutics > Immunology And Immunotherapy
Insulin Crys
t
als Removal Platform
Descrip
t
ion: A platform technology for improving insulin delivery by removing insulin-derived fibrils through polyester membrane filtration. This invention employs membrane filters integrated into insulin delivery systems to selectively remove insulin-derived fibrils (IDFs) from insulin formulations. By filtering out fibrils while preserving active...
Published: 1/27/2026
|
Inventor(s):
Ulrike Klueh
Keywords(s):
Category(s):
T
echnology Category > Biomedical
,
T
echnology Category > Devices
,
T
echnology Category > Drug Delivery
,
T
echnology Category > Life Science
,
T
echnology Category > Medical Devices
Sys
t
ems and Methods for 3D Volumetric Mesh Transformer
Inven
t
ion Description Conducting learning-based models on large-scale unstructured geometric data, particularly volumetric 3D meshes, remains a significant challenge. While previous methods have employed graph convolutional approaches, they suffer from high space complexity, limiting efficient mini-batch training, as well as fixed short-range feature...
Published: 1/28/2026
|
Inventor(s):
Yalin Wang
,
Mohammad Farazi
,
Yanxi Chen
Keywords(s):
Category(s):
Ar
t
ificial Intelligence/Machine Learning
,
Compu
t
ing & Information Technology
,
Imaging
,
Medical Imaging
,
Neurodegenera
t
ive Disease Technologies
,
Life Science (All LS
T
echs)
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