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ID
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Quinoline-derived SARS-CoV-2 papain-like pro
t
ease inhibitors are oral antiviral drug candidates
A lead compound,
t
he quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Prakash Jadhav
,
Bin
T
an
,
Haozhou
T
an
Keywords(s):
An
t
iviral
Category(s):
T
echnology Classifications > COVID-19
,
T
echnology Classifications > Healthcare & Life Sciences
,
T
echnology Classifications > Infectious Disease
,
T
echnology Classifications > Therapeutics
Specific inhibi
t
ors to mitigate mu opioid‐induced side‐effects without compromising analgesia
Preliminary da
t
a shows that the inhibitor significantly mitigates morphine tolerance in a mouse study Invention Summary: Mu opioids such as morphine and fentanyl are commonly used for pain management but can lead to tolerance, addiction, and opioid use disorder. Current therapeutic solutions for these adverse conditions include buprenorphine,...
Published: 7/31/2025
|
Inventor(s):
Yingxian Pan
Keywords(s):
Category(s):
T
echnology Classifications > Healthcare & Life Sciences
,
T
echnology Classifications
,
T
echnology Classifications > Therapeutics
Me
t
hod for Optimizing an Integrated Flight Control System using Reinforcement Meta-Learning
T
his technology is a method to incorporate reinforcement meta-learning to the design of a flight control system for missiles. The integration will benefit the control system, as it optimizes it with the help of a simulation environment. The technology removes the need for manual tuning of the control system settings. Background: The flight control...
Published: 7/30/2025
|
Inventor(s):
Rober
t
o Furfaro
,
Brian Gaude
t
Keywords(s):
Category(s):
T
echnology Classifications > Software & Information Technology
,
T
echnology Classifications > Engineering & Physical Sciences > Aerospace Engineering
T
RP: A Mouse Model of Limb Girdle Muscular Dystrophy Type 2A (R1/D4) (UCLA Case No. 2021-171)
UCLA researchers in
t
he Department of Neurology have developed a novel mouse model for limb girdle muscular dystrophy, a disorder that causes muscle weakness in the limbs and hip area. BACKGROUND: Limb-Girdle Muscular Dystrophy Type 2A (LGMDR1) is a genetic neuromuscular disorder characterized by progressive muscle weakness, primarily affecting muscles...
Published: 7/30/2025
|
Inventor(s):
Melissa Spencer
Keywords(s):
Category(s):
Life Science Research
T
ools > Animal Models
Regioselec
t
ive 1,2-Dearomatization of Functionalized Azines by Organolanthanide Catalysts
NU2014-129 INVEN
T
ORS Tobin Marks* Alexander Dudnik Massimiliano Delferro Victoria Weidner SHORT DESCRIPTION This invention describes a catalytic process for the regioselective 1,2-dearomatization of functionalized azines using an organolanthanide catalyst and pinacolborane (HBpin). It offers a streamlined approach to key intermediates for pharmaceuticals...
Published: 7/30/2025
|
Inventor(s):
Keywords(s):
Ca
t
alyst
,
Chemicals
,
Manufac
t
uring/Processing
,
Ma
t
erials
Category(s):
Physical Sciences > Ma
t
erials and Industrial Processes
Novel self-healing commodi
t
y copolymers based on 2-ethylhexyl acrylate
NU2023-240 INVEN
T
ORS John Torkelson* Tong Wang SHORT DESCRIPTION This invention describes a new class of random copolymers that exhibit autonomous self-healing behavior at room temperature. The copolymers, derived entirely from commodity comonomers including 2-ethylhexyl acrylate, fully recover their material properties after damage. BACKGROUND The...
Published: 7/30/2025
|
Inventor(s):
Keywords(s):
Ma
t
erials
,
Polymer
,
Smar
t
/Functional materials
Category(s):
Physical Sciences > Ma
t
erials and Industrial Processes
Mul
t
i-Particle System for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)
Summary: UCLA researchers in
t
he Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 7/29/2025
|
Inventor(s):
Dino Di Carlo
,
Alyssa Arnheim
,
Michael Mellody
,
Yu
t
a Nakagawa
,
Lily Shang
Keywords(s):
Assay
,
B Cell
,
barcode
,
Bioassay
,
biological assays
,
Biomarker
,
biomarkers
,
Bioma
t
erial
,
capping par
t
icles
,
CAR-
T
cell platform
,
CAR-
T
cell therapy
,
cavi
t
ies
,
cavi
t
y-containing particles
,
Cell and
t
issue culture
,
cell encapsula
t
ion
,
cell engineering
,
cell imaging
,
cell mapping
,
cell sor
t
ing
,
cell
t
ype identification
,
cell-based
t
herapy
,
cen
t
rifugation
,
confinemen
t
,
Diagnos
t
ic Platform Technologies (E.G. Microfluidics)
,
Digi
t
al Microfluidics
,
Drug
,
Drug Delivery
,
Drug Discovery
,
drug screening
,
high
t
hroughput
,
high
t
hroughput assays
,
high
t
hroughput testing
,
high-
t
hroughput analysis
,
High-
T
hroughput Screening
,
Immunoassay
,
Immunoassay Sense (Molecular Biology)
,
Microfluidics
,
Microfluidics And Mem's
,
Microfluidics Nanosphere
,
micropar
t
icles
,
moie
t
ies
,
Nanopar
t
icle
,
single cell analysis
,
single cell analysis and
t
esting
,
Single cell da
t
a
,
single-cell resolu
t
ion
,
single-cell
t
rapping
Category(s):
Life Science Research
T
ools
,
Life Science Research
T
ools > Cell Counting And Imaging
,
Life Science Research
T
ools > Lab Equipment
,
Life Science Research
T
ools > Microscopy And Imaging
,
Life Science Research
T
ools > Microfluidics And Mems
,
Medical Devices
,
Pla
t
forms
Covalen
t
Adaptable Networks with Associative Siloxane Exchange Enabled by Amide-Based Internal Catalysis
NU2025-056 INVEN
T
ORS John Torkelson* Tapas Debsharma Nathan Purwanto Tong Wang SHORT DESCRIPTION A technology that introduces internally catalyzed siloxane dynamic chemistry in covalent adaptable networks (CANs) through amide-based catalysis to produce recyclable and reprocessable polymers with maintained cross-link density at elevated temperatures. BACKGROUND Replacing...
Published: 7/29/2025
|
Inventor(s):
Keywords(s):
Category(s):
Physical Sciences > Ma
t
erials and Industrial Processes
Recyclable and Depolymerizable Polymer Ne
t
work Materials via Thiourethane Dynamic Chemistry
NU2019-126 INVEN
T
ORS John Torkelson* Lingqiao Li Xi Chen SHORT DESCRIPTION A class of reprocessable, PU-like polymer networks synthesized via thiourethane dynamic chemistry that allow for complete cross-link density recovery and offer the potential for monomer recovery under mild conditions. BACKGROUND Traditional cross-linked polyurethane...
Published: 7/29/2025
|
Inventor(s):
Keywords(s):
Category(s):
Physical Sciences > Ma
t
erials and Industrial Processes
Fusion Pro
t
ein for Development of Transgenic Resistance to Lepidopteran Pests
A Specific, Eco-Friendly Approach
t
o Pest Control Using Genetically Engineered Biopesticides A fusion protein comprised of a densovirus coat protein, a proline-rich linker, and an insect-specific neurotoxin allows for the development of transgenic crops with resistance to lepidopteran (caterpillar) pests. Insects cause agricultural loss and economic...
Published: 7/31/2025
|
Inventor(s):
Bryony Bonning
Keywords(s):
Category(s):
T
echnology Classifications > Agricultural > Insect Control
,
T
echnology Classifications > Agricultural > Therapeutics
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