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Pancreas Cancer Immuno
t
herapy using Cationic Lipid and Polymer Nanocarriers for co-delivery of KRAS Neoantigens and STING or other immunomodulators to boost the Cancer Immunity Cycle and Treat Liver Metastasis (UCLA Case No. 2024-076)
UCLA researchers have developed a
t
ranslational immunotherapy platform that leverages nanoparticle-based delivery of tumor-associated signals and immune-stimulatory molecules to drive localized immune activation in metastatic pancreatic cancer. This approach is designed to initiate de novo immune priming and recondition the tumor microenvironment in...
Published: 10/29/2025
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Inventor(s):
Andre Nel
Keywords(s):
Category(s):
T
herapeutics > Oncology
,
T
herapeutics > Immunology And Immunotherapy
,
T
herapeutics > Vaccines
,
Pla
t
forms > Drug Delivery
Novel Adsorben
t
for Wastewater Treatment and Metal Recovery
Inven
t
ion Description Heavy metals are non-biodegradable and can contaminate in ecosystems and the food chain, making them one of the most pressing environmental issues of our time. Certain industrial practices have resulted in an increase in the amount of heavy metals discharged into wastewater which can then leach into or contaminate other water...
Published: 10/29/2025
|
Inventor(s):
Elham Fini
,
Farideh Pahlavan
Keywords(s):
Category(s):
Advanced Ma
t
erials/Nanotechnology
,
Environmen
t
al
,
Environmen
t
al Remediation/Wastewater Treatment
,
Physical Science
Unified Model of Alzheimer’s Disease Pa
t
hobiology
Inven
t
ion Description Understanding of the pathobiology of Alzheimer’s disease (AD) has long been fragmented, with much research centered around biological mechanisms including amyloid β or tau proteins, inflammation, cell death pathways, glia, mitochondria and more. While these all deal with real facets in the biology of AD, they are limited...
Published: 10/29/2025
|
Inventor(s):
Carol Huseby
,
Elaine Delvaux
,
Paul Coleman
Keywords(s):
Category(s):
Diagnos
t
ic Assays/Devices
,
Life Science (All LS
T
echs)
,
Medical Diagnos
t
ics/Sensors
,
Neurodegenera
t
ive Disease Technologies
,
Pharmaceu
t
icals
Non-Des
t
ructive Material Characterization of Crystalline Silicon Solar Photovoltaic Panels
Inven
t
ion Description Crystalline silicon (c-Si) photovoltaic (PV) panels contain a mix of bulk materials (such as glass, silicon, and aluminum), toxic substances (like lead, tin, and copper), and precious metals. Due to solar panel designs not being standardized, their compositions vary. Panels with lead-based solder, for example, contain more lead...
Published: 10/29/2025
|
Inventor(s):
Dwarak Ravikumar
Keywords(s):
Category(s):
Applied
T
echnologies
,
Environmen
t
al
,
Physical Science
,
Manufac
t
uring/Construction/Mechanical
His
t
one H1 as a Therapeutic Target for Fibrosis (UCLA Case No. 2023-148)
UCLA researchers from
t
he David Geffen School of Medicine have identified linker histone H1 as a critical regulator of pathologic gene expression and cellular mechanics, establishing its potential role as a therapeutic target for the treatment of fibrosis. BACKGROUND: Heart failure affects ~6 million Americans and has a 5-year survival rate of ~50%...
Published: 10/29/2025
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Inventor(s):
T
homas Vondriska
Keywords(s):
Category(s):
T
herapeutics > Cardiovascular
Elec
t
ronic-Photonic Quadrature Delay-Locked Oscillator (DLO) For Efficient High-Speed Clock Generation And Distribution
A Quadra
t
ure Delay-Locked Oscillator that caters to increasing multi-GHz and multi-phase clock demands in systems such as time-interleaved architectures. Problem: The unrelenting growth of artificial intelligence (AI) requires advancements in high-performance hardware capable of delivering high-speed clock generation and distribution. These improvements...
Published: 10/29/2025
|
Inventor(s):
Firooz Afla
t
ouni
,
Henry Love
Keywords(s):
Ar
t
ificial Intelligence (AI) & Machine Learning
,
Elec
t
ronic Materials
,
Op
t
ics & Photonics
Category(s):
T
echnology Classifications > Computer Information Systems
,
T
echnology Classifications > Hardware & Components
Ready for
T
onsillectomy Mobile App
Applica
t
ion A child-friendly mobile application designed to educate children and caregivers on the purpose of tonsillectomies and guide them through pre-, intra-, and post-operative care using age-appropriate, interactive content. Key Benefits The app is interactive and provides education at a child’s literacy level. Market Summary Tonsillectomies...
Published: 10/29/2025
|
Inventor(s):
Holly Cordray
,
Nikhila Raol
,
Kara Pricke
t
t
Keywords(s):
Heal
t
hcare Professional Education and Training
,
Mobile Apps
,
Pedia
t
rics
Category(s):
T
echPub Algolia > Software
Syn
t
hetic Peptide Antigens to Detect Anti-Nephrin Autoantibodies
NU2025-147 Inven
t
ors Jing Jin* Pan Liu Short Description The invention provides a method for detecting anti-nephrin autoantibodies implicated in kidney diseases like minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). This method employs synthetic peptide antigens for use as a clinical diagnostic. Background Kidney...
Published: 10/28/2025
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Inventor(s):
Keywords(s):
Category(s):
Life Sciences > Biomarkers & Biomedical Research
T
ools
Precision DNA PCR-based Assay for Gardnerella vaginalis species in bac
t
erial vaginosis
PAGE
T
ITLE Overview PAGE SUMMARY This new PCR-based companion diagnostic assay leverages genetic analysis to identify specific members of the Gardnerella vaginalis species and detects resistance to metronidazole, the current first-line treatment for bacterial vaginosis (BV). BV is a prevalent vaginal infection with ~30% annual incidence, high recurrence...
Published: 10/28/2025
|
Inventor(s):
Gar
t
h Ehrlich
,
Ka
t
herine Innamorati
,
Joshua Earl
Keywords(s):
Category(s):
Medical Devices, Diagnos
t
ics & Biosensors
Highly-Sensi
t
ive Point-of-Care Diagnostics & Disease Monitoring
Descrip
t
ion This technology is a novel, highly-sensitive platform to diagnose and monitor diseases in real time at a doctor’s office. Many chronic diseases like cancer and IBD do not have initial screening tests and solely rely on invasive, uncomfortable and time-consuming procedures (like biopsies and colonoscopies). Having a less invasive...
Published: 10/28/2025
|
Inventor(s):
A. G. Unil Perera
,
Ma
t
hes Dayananda
,
Hemendra Ghimire
,
Mehmood Piarzada
Keywords(s):
Category(s):
Assay
,
Device
,
Diagnos
t
ic
,
Imaging
,
Research
T
ool
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