Search Results - multiple+sclerosis

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IL7Rα-Specific Antibody for Treating Acute Lymphoblastic Leukemia (ALL)
Abstract: Acute lymphoblastic leukemia (ALL) is the most common cancer in children with approximately 3,250 new cases occurring per year in the United States. About 20% of cases are refractory to current treatment protocols and there is a desperate need for targeted therapies that do not result in adverse side effects such as cognitive impairment.  The...
Published: 4/8/2024   |   Inventor(s): Scott Durum, Julie Hixon, Wenqing Li, Scotch Walsh, Lila Kashi
Keywords(s): Acute lymphoblastic leukemia (ALL), ANTIBODY, Antibody-Dependent Cellular Cytotoxicity (ADCC), Autoimmunity, CANCER, DIABETES, Durum, Interleukin-7 receptor-α (IL-7Rα), Multiple sclerosis, personalized medicine, Targeted therapy, THERAPY, TRANSPLANTATION
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration
Glial Cell Line-Derived Neurotrophic Factor for the Treatment of Neurodegenerative Diseases and Diabetes
Abstract: The National Institute on Drug Abuse (NIDA) is seeking interested parties to license or co-develop GDNFOS peptides and non-coding RNAs as therapeutic agents for neurodegenerative diseases. Glial cell line-derived neurotrophic factor (GDNF) is a small human protein encoded by the GDNF gene. GDNF has been effective therapy in laboratory animal...
Published: 4/8/2024   |   Inventor(s): Qing Rong Liu
Keywords(s): ALS, GDNFOS3., Glial Cell Line Derived Neurotrophic Factor (GDNF), Multiple sclerosis, Parkinson's Disease
Category(s): TherapeuticArea > Neurology, Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration
Interleukin 24 (IL-24) to treat inflammatory diseases
Abstract: Proinflammatory T-helper 17 cells (Th17) play important roles in host immune defense against infection, but uncontrolled activation of these cells, known as the Th17 response, may cause autoimmune and autoinflammatory diseases (uveitis, multiple sclerosis, rheumatoid arthritis, and Crohn’s disease) through the effects of Th17 lineage...
Published: 4/8/2024   |   Inventor(s): Rachel Caspi, Mary Mattapallil, Reiko Yamane, Wai Po Chong
Keywords(s): Caspi, Crohn’s disease, IL-24, inflammatory disease, interleukin 24, Multiple sclerosis, National Eye Institute, NEI, proinflammatory T-helper 17 cell, RHEUMATOID ARTHRITIS, Th17, uveitis
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Immunology
Ex-vivo Production of Regulatory B-Cells for Use in Auto-immune Diseases
Abstract: Regulatory B-cells (Breg) play an important role in reducing autoimmunity and reduced levels of these cells are implicated in etiology of several auto-inflammatory diseases. Despite their impact in many diseases, their physiological inducers are unknown.  Given that Bregs are a very rare B-cell, identifying factors that promote their development...
Published: 8/14/2024   |   Inventor(s): Charles Egwuagu, Ren-Wi Wang, Chengrong Yu
Keywords(s): ARTHRITIS, B-CELL, COLITIS, EYE, Multiple sclerosis, sarcoidosis
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology
Glucocorticoid-induced TNFR Family-Related Receptor Ligand (GITRL) Antibodies for Diagnosis and Treatment of Immune System Disorders
This technology provides novel antibodies and methods for diagnostics and treatment of disorders arising from dysregulation of the immune system using antibodies directed against glucocorticoid-induced tumor necrosis factor receptor family-related receptor ligand (GITRL). Also available are hybridomas producing anti-mouse GITRL monoclonal antibodies...
Published: 10/28/2024   |   Inventor(s): Ethan Shevach
Keywords(s): antibodies, AUTOIMMUNE DISEASE, CD25, CD4, GITR, GITRL, IB3XXX, IBXXXX, IDXXXX, immune response, immune suppressor, IXXXXX, Multiple sclerosis, Patent Category - Biotechnology, RHEUMATOID ARTHRITIS, T cell, Treg
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
Prevention and Treatment of Multiple Sclerosis (MS) by Administering E-Selectin
The invention is a method and composition for inhibiting or treating symptoms of inflammatory demyelination or inflammation associated with autoimmune disorders. This is accomplished by administering recombinant E-selectin protein intranasally and resulting in E selectin-specific regulatory T-cells. These regulatory T-cells suppress activation of blood...
Published: 4/8/2024   |   Inventor(s): Jacqueline Shukaliak-Quandt
Keywords(s): ANIMAL, Autoimmune, BBXXXX, BCXXXX, brain, Damage, EAE, Encephalomylelitis, e-selectin, EXPERIMENTAL, IMMUNOLOGICAL, Model, Multiple sclerosis, NB1HXX, NB1JXX, NB1XXX, NBXXXX, NXXXXX, PREVENTS, Tolerization
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Neurology
The preparation of a brain targeted artificial nano-enzyme and application
Reference #: 01514 The University of South Carolina is offering licensing opportunities for The preparation of a brain targeted artificial nano-enzyme and application Background: Chronic neuroinflammation is caused by the activation of microglia, which is the major cause of central neuronal system (CNS) diseases, including Alzheimer’s disease,...
Published: 4/25/2024   |   Inventor(s): Peisheng Xu, Haijun Liu
Keywords(s): Alzheimer’s disease, Amyotrophic lateral sclerosis, brain injury, Brain targeted nanoparticle, Brain tumor, Epilepsy, frontotemporal dementia, glioblastoma, Huntington's disease, Multiple sclerosis, neonatal hypoxic-ischemic, neuroblastoma, Parkinson's disease, post-traumatic stress disorder, Spinal cord injury, stroke
Category(s): Nanotechnology, Health Sciences, Biomedical and Life Sciences
Antigen-Specific Tolerizing Treatment for Multiple Sclerosis
Localized, Antigen-Specific, Immunomodulatory Treatment for Multiple Sclerosis Without Global ImmunosuppressionThis antigen-specific microparticle therapy is a robust and highly efficacious, localized treatment for multiple sclerosis (MS) without provoking global immunosuppression. MS is the most common, potentially disabling, neurological disease typically...
Published: 7/18/2023   |   Inventor(s): Dorina Avram, Benjamin Keselowsky
Keywords(s): antigen specific, microparticle deliver, multiple sclerosis, myelin, Therapeutic, Therapy
Category(s): Technology Classifications > Human Health Care > Therapeutics