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A Novel Reagent for Labeling PET Tracers at Trifluoromethyl Groups

The molecular imaging technique of positron emission tomography (PET) is an increasingly important tool in biomedical research and in drug discovery and development. Many small molecule drugs and potential PET radiotracers carry trifluoromethyl (CF3) groups. Because CF3 groups are generally considered to be metabolically stable, there is a strong interest...

Published: 10/28/2024 | Inventor(s): Mohammad Haskali, Victor Pike

Keywords(s): :, [11C]Fluoroalkanes, Added, AGENT, LABELING, Method, No-Carrier, PET, Producing, Radiotracers, VAXXXX, VCXXXX, VDXXXX, VEXXXX, VNXXXX, WBXXXX, WIXXXX, XDXXXX, XFXXXX, YAXXXX, YBXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Geriatrics, Application > Software / Apps, TherapeuticArea > Psychiatry/Mental Health, TherapeuticArea > Neurology, Application > Medical Devices, TherapeuticArea > Immunology

Regenerative Therapy for Cartilage Damage

The subject technology discloses a tissue engineering method for treating cartilage damage. Stem cells from bone marrow are attached to a novel scaffold, hyaluronic acid-coated fibrin microbeads, and transferred to a live host to form cartilage. The regenerated cartilage is stable and not hypertrophic, which has been problematic in the current regenerative...

Published: 8/21/2024 | Inventor(s): Mitchell Shirvan, Rafael Gorodetsky, Sergei Kuznetsov, Astar Lazmi-Hailu, Pamela Robey

Keywords(s): Bone, Cartilage, Cells, Fibrin, Generation, Human, Hyaline, Marrow, Microbeads, STABLE, Stromal, TRANSPLANTATION, VAXXXX, Vivo, WJXXXX, XCXXXX, XDXXXX, YAXXXX, YBXXXX, YCXXXX

Category(s): Application > Diagnostics, Application > Research Materials, Application > Non-Medical Devices, Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Geriatrics, Application > Medical Devices

Occupational Health: Wearable Kneel-Sit Support Device for Manual Labor and Heavy Industry Applications

This CDC-developed technology describes a novel ergonomic device that supports a portion of the worker's weight while kneeling, relieving the knee pressure and pain common to many manual labor occupations. Unfortunately, many of the devices that have been used in the past to relieve pressure on the knees are bulky, heavy, and of questionable durability. This...

Published: 10/28/2024 | Inventor(s): Ova Johnston, Stephen Hudock, Steven Wurzelbacher

Keywords(s): AB1XXX, AB3GXX, AB3XXX, AE2BXX, AE2XXX, AE4XXX, AEXXXX, AFXXXX, ARTHRITIS, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DEVICE, Knee, Kneel-sit, LABOR, MINING, NIOSH, NIOSH-DART, OSHA, OSTEOARTHRITIS, SAFETY, SUPPORT, VAXXXX, VMXXXX, VPXXXX, Wearable, WEXXXX, WGXXXX, WMXXXX, WORK, WORKER, WORKER safety, WORKERS, XDXXXX, XIXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Medical Devices, TherapeuticArea > Geriatrics, Application > Occupational Safety and Health, TherapeuticArea > Ophthalmology, TherapeuticArea > Dental, Application > Consumer Products, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, TherapeuticArea > Immunology, TherapeuticArea > Neurology, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Infectious Disease

Role of Novel Hepatitis Delta Virus Variant in Sjogren’s Syndrome

Sjögren’s is a chronic autoimmune disease characterized by dry mouth and eyes, fatigue, and musculoskeletal pain resulting from the attack of the moisture-producing glands by the body’s own white blood cells. The subject invention is based on the discovery of an association between infection by a novel clade 1 variant of hepatitis delta virus (HDV)...

Published: 10/28/2024 | Inventor(s): Melodie Weller, John (Jay) Chiorini

Keywords(s): DAXXXX, DBXXXX, DELTA, detected, GLANDS, Hepatitis, Salivary, Sjgrens, Syndrome, VAXXXX, virus, VLXXXX, WBXXXX, WIXXXX, WJXXXX, WKXXXX, XAXXXX, XHXXXX, YAXXXX, YBXXXX, YCXXXX

Category(s): TherapeuticArea > Infectious Disease, Application > Therapeutics, ResearchProducts > Research Equipment, TherapeuticArea > Geriatrics, Application > Research Materials, TherapeuticArea > Immunology, Application > Diagnostics, ResearchProducts > Antibodies

Human iPSC-Derived Mesodermal Precursor Cells and Differentiated Cells

Cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derived cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines are disclosed. Human induced pluripotent stem cells (hiPSCs) can be generated by reprogramming somatic cells by the expression...

Published: 10/28/2024 | Inventor(s): Guibin Chen, Mahendra Rao, Andre Larochelle, Manfred Boehm

Keywords(s): Cells, Hematopoetic, Human, IB6XXX, IDXXXX, IPSC-derived, Screenings, THERAPIES, Toxicology/drug, Vascular-related, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WGXXXX, WHXXXX, WIXXXX, WJXXXX, WKXXXX, WMXXXX, YAXXXX, YBXXXX, YCXXXX

Methods for Amelioration and Treatment of Pathogen-associated Inflammatory Response

This CDC invention provides methods for preventing or treating inflammatory response-linked, infection induced pathologies, which are mediated by endogenous substance P. Substance P is a naturally-occurring and major pro-inflammatory neuromediator or neuromodulator, and elevated levels of substance P have been implicated in numerous inflammation-associated...

Published: 10/28/2024 | Inventor(s): Larry Anderson, Deborah Moore, Ralph Tripp

Keywords(s): bronchoilitis, CAUSED, CDC Docket Import, CDC Docket Import CDC Prosecuting, DB3XXX, DB4XXX, DBXXXX, DISEASES, DXXXXX, IB3XXX, Infection, Inflammation, INFLAMMATORY, Methods, nitric oxide, OID-NCIRD-DVD, P, Pain, pain control, Prevention, Pulmonary, RESPONSE, RSV, RSV virus, SUBSTANCE, SUBSTANCE p, treatment, treatment methods, vasodilation, VASODILATOR, VAXXXX, VBXXXX, VDXXXX, VEXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VOXXXX, VPXXXX, WAXXXX, WIXXXX, WJXXXX, WKXXXX, WMXXXX, XAXXXX, XCXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Ophthalmology, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, TherapeuticArea > Oncology, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Vaccines, ResearchProducts > Antibodies, TherapeuticArea > Immunology, TherapeuticArea > Neurology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Geriatrics

Diagnostic Antigens for the Identification of Latent Tuberculosis Infection

CDC researchers have developed technology for sero-diagnosis of typically symptomless latent stage tuberculosis disease, posing a threat to individuals under immunosuppressive or anti-inflammatory therapies. Specifically, this diagnostic approach exploits M. tuberculosis secreted latency specific antigens, such as alpha-crystallin, in the blood or urine...

Published: 10/28/2024 | Inventor(s): Manon Deslauriers, Kristin Birkness, Peter King, Bernard Beall, Frederick Quinn

Keywords(s): ANTIGENS, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, DC4XXX, DCXXXX, DDXXXX, DEXXXX, diagnostic, DXXXXX, Granuloma, Human, IA3XXX, Identification, Latent, Methods, Model, OID-NCHHSTP-DTE, TUBERCULOSIS, VAXXXX, Vitro, VJXXXX, WBXXXX, WFXXXX, WIXXXX, XAXXXX, XCXXXX, YBXXXX, YDXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Geriatrics, TherapeuticArea > Immunology, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Research Materials, Application > Diagnostics, ResearchProducts > Antibodies, Application > Vaccines, Application > Occupational Safety and Health

Methods of Retaining Methylation Pattern Information in Globally Amplified DNA

CDC researchers have developed a novel method that generates globally amplified DNA copies retaining parental methylation information; making accurate DNA-archiving for methylation studies much more feasible and cost-effective than undertaking such an endeavor with alternate technologies. This unique approach eliminates a significant bottleneck in...

Published: 10/28/2024 | Inventor(s): Elizabeth Unger, Mangalathu Rajeevan

Keywords(s): AA5XXX, AAXXXX, AC4XXX, AC5XXX, AC6XXX, ACXXXX, AG2XXX, Amplified, AXXXXX, CC1XXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DA2XXX, DA3XXX, DA4AXX, DA4BXX, DA4XXX, DA5XXX, DAXXXX, DDXXXX, DNA, GAXXXX, GCXXXX, Globally, Method, Methylation, NA2BXX, NC3XXX, NC4XXX, NC5XXX, OID-NCEZID-DHCPP, Pattern, RETAINING, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VNXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WIXXXX, WMXXXX, XBXXXX, XCXXXX, XEXXXX, XHXXXX, YBXXXX

Automated Microscopic Image Acquisition, Compositing and Display Software Developed for Applied Microscopy/Cytology Training and Analysis

Micro-Screen is a CDC developed software program designed to capture images and archive and display a compiled image(s) from a portion of a microscope slide in real time. This program allows for the re-creation of larger images that are constructed from individual microscopic fields captured in up to five focal planes and two magnifications. This program...

Published: 10/28/2024 | Inventor(s): Roger Taylor, James Lange, Tommy Lee, Carlyn Collins, MariBeth Gagnon

Keywords(s): AA3AXX, AA3B6X, AA3CXX, AA3XXX, AC2XXX, AC3XXX, Acquisition, ACXXXX, AD2XXX, AD3XXX, ADXXXX, Automated, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositing, DISPLAY, Image, MICROSCOPIC, OID-NCPDCID-DLS, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VNXXXX, VOXXXX, VPXXXX, WBXXXX, WIXXXX, WMXXXX, XDXXXX, XFXXXX, XHXXXX, XJXXXX, YBXXXX, YEXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Psychiatry/Mental Health, Application > Consumer Products, TherapeuticArea > Neurology, TherapeuticArea > Oncology, ResearchProducts > Computational models/software, TherapeuticArea > Cardiology, TherapeuticArea > Dental, Application > Medical Devices, TherapeuticArea > Geriatrics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Immunology, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, Application > Non-Medical Devices, TherapeuticArea > Infectious Disease, Application > Software / Apps, Application > Research Materials, ResearchProducts > Research Equipment, Application > Diagnostics

Cylindrical Handle Dynamometer for Improved Grip-Strength Measurement

CDC researchers have developed an improved dynamometer device and method for measuring maximum hand grip force or grip-strength. Human test subjects were used in conducting experiments to evaluate the handle and to assess the measurement method. In contrast to the currently used "Jamar handle" grip strength dynamometer devices, the cylindrical handle...

Published: 10/28/2024 | Inventor(s): Daniel Welcome, Christopher Warren, Thomas McDowell, Renguang Dong, Bryan Wimer

Keywords(s): AA1XXX, AA2XXX, AA4BXX, AA4XXX, AAXXXX, AB1XXX, AFXXXX, ASSESSMENT, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Configuration, Dynamometer, GRIP, HAND, Improved, NIOSH-HELD, Strength, VAXXXX, VEXXXX, VPXXXX, WBXXXX, WGXXXX, XDXXXX, XIXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Ophthalmology, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Non-Medical Devices, TherapeuticArea > Cardiology, TherapeuticArea > Neurology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Immunology, TherapeuticArea > Oncology, TherapeuticArea > Geriatrics, Application > Medical Devices

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