Search Results - interferon+gamma

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A Murine Model of Inflammation Based on Chronic Expression of Interferon-Gamma
Abstract: An autoimmune disease is characterized by a malfunctioning healthy immune system mistakenly attacking healthy cells, tissues, and organs. These chronic diseases likely result from interactions between genetic and environmental factors. Gender, race, and ethnicity characteristics have been linked to the development of an autoimmune disease....
Published: 4/8/2024   |   Inventor(s): Howard Young, Deborah Hodge
Keywords(s): Autoimmune, Autoinflammatory, IFNγ, immunomodulatory, immunostimulatory, Interferon gamma, Ovarian Failure Syndrome, Primary Biliary Cholangitis, Systemic lupus erythematosus, Young
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology
Peptide Inhibitors for Viral Infections and as Anti-inflammatory Agents
Abstract: IFN-gamma and IL-10 are cytokine signaling molecules that play fundamental roles in inflammation, cancer growth and autoimmune diseases.  Unfortunately, there are no specific inhibitors of IFN-gamma or IL-10 on the market to date. NCI investigators at the Cancer and Inflammation Program have synthesized short peptides that selectively interfere...
Published: 4/8/2024   |   Inventor(s): Nadya Tarasova, Giorgio Trinchieri, Howard Young, C. Andrew Stewart, Marco Cardone, Alan Perantoni
Keywords(s): IFN-gamma, Interferon gamma, INTERLEUKIN, Peptide, Peptidometic, psoriasis, Synthetic Peptide Inhibitors
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Dermatology, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology
Magnetic Nanoparticles and Microneedle Tip That Collect Biomarkers for Safe, Early-Stage Arthritis Diagnosis and Monitoring
Allows for Early Intervention, Which Can Delay Osteoarthritis ProgressionThese magnetic nanoparticles and specialized magnetic microneedle tips safely collect biomarkers that indicate early-stage osteoarthritis in knees, hips and other joints. Osteoarthritis affects 12.1 percent of American adults - nearly 27 million people, costing the nation an estimated...
Published: 6/27/2021   |   Inventor(s): David Arnold, Jon Dobson, Elena Yarmola, Zachary Kaufman, Kyle Allen
Keywords(s): inflammatory mediators, Interferon gamma, interleukin-1, interleukin-6, Magnetic Nanoparticle, prostaglandin E, tumor necrosis factor
Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Medical Devices