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PROFILING CELL TYPES IN CIRCULATING NUCLEIC ACID LIQUID BIOPSY
PROFILING CELL TYPES IN CIRCULATING NUCLEIC ACID LIQUID BIOPSY Researchers at Stanford have developed a method to identify cell types of origin for cell-free RNA from liquid biopsies for a variety of diseases. Cell-free RNA (cfRNA) in blood plasma samples enables dynamic and longitudinal phenotyping for physiological conditions spanning oncology,...
Published: 7/6/2023   |   Inventor(s): Sevahn Vorperian, Stephen Quake, Mira Moufarrej
Keywords(s): Biopsy, Cell Free RNA, Cell Pathophysiology, Cell-Of-Origin Identity, Disease, Liquid
Category(s): Technology Classifications > Biology
Murine Model of Niemann-Pick Disease Type C
This technology includes a transgenic mouse model of Niemann-Pick Disease Type C (NPC), which is a rare neurodegenerative disorder, characterized by intracellular accumulation of cholesterol and gangliosides. The mouse strain, Tg(Npcl), expresses wild-type NPC1 gene under the control of the prion promoter. When combined with the NPC deficient mouse...
Published: 10/28/2024   |   Inventor(s): Stacie Loftus, William ("Bill") Pavan
Keywords(s): C, Disease, Listed LPM Maddox as of 4/15/2015, Model, Murine, NIEMANN-PICK, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RXXXXX, VEXXXX, VHXXXX, VNXXXX, VPXXXX, WIXXXX, WKXXXX, XEXXXX
Category(s): TherapeuticArea > Infectious Disease, TherapeuticArea > Psychiatry/Mental Health, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, TherapeuticArea > Neurology, Application > Research Materials, TherapeuticArea > Ophthalmology
Mouse Model Created Using Glucocerebrosidase-Deficient Neuronal Cell Line to Study Gaucher Disease Pathophysiology and Evaluate New Therapies
This technology includes a high-yield, easy-to-culture mouse neuronal cell model with nearly complete glucocerebrosidase deficiency representative of Gaucher disease (GD) to study pathophysiology and evaluate new therapies. GD is an autosomal recessive lysosomal storage disorder caused by loss-of function mutations in the GBA1 gene, which codes for...
Published: 10/28/2024   |   Inventor(s): Matthew Nguyen, Wendy Westbroek, Nahid Tayebi, Ellen Sidransky
Keywords(s): Cell, DEFICIENT, Disease, Gaucher, GLUCOCEREBROSIDASE, Line, Model, Mouse, NEURONAL, VEXXXX, VPXXXX, WIXXXX, XEXXXX
Category(s): TherapeuticArea > Neurology, Application > Research Materials, TherapeuticArea > Dental, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease
Murine Models of an Autoinflammatory Disease, Familial Mediterranean Fever (FMF), to Study the Pathophysiology of Inherited Disorders of Inflammation and Evaluate New Therapies
This technology includes mouse models (heterozygous for the knock-in (KI) and homozygous for the knock-out (KO)) to be used as research reagents and to study molecular mechanisms and potential therapies for Familial Mediterranean fever (FMF). FMF is the prototype of a group of inherited disorders characterized by recurring, spontaneous episodes of fever...
Published: 10/28/2024   |   Inventor(s): Jae Chae, Daniel ("Dan") Kastner
Keywords(s): Autoinfla~-~atory, Autoinflamatory, Disease, FAMILIAL, FEVER, FMF, MEDITERRANEAN, Models, Murine, VPXXXX, WIXXXX, XEXXXX
Category(s): Application > Therapeutics, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Dental, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease
A Group of Compounds that Activate AMP-activated protein kinase (AMPK) that may Treat Niemann-Pick Disease Type C (NPC)
This technology relates to the identification and use of a group of compounds that activate the AMP-activated protein kinase (AMPK) and also effectively reduce lysosomal cholesterol accumulation in patients with Niemann-Pick disease Type C (NPC). Clinical trials are currently underway to determine the efficacy of beta-cyclodextrin in treating patients...
Published: 10/28/2024   |   Inventor(s): Zachery Caffall, Joseph Rittiner, Nicole Calakos
Keywords(s): AMPK, C, Compositions, Disease, DISORDERS, Dystonia, Identifying, Methods, MODULATORS, Niemann, Pick, TREATING, treatment, TYPE, VEXXXX, WIXXXX, WKXXXX, XEXXXX
Category(s): TherapeuticArea > Neurology, Application > Therapeutics, Application > Research Materials
Patient-derived induced pluripotent stem cell (iPSC) lines for the study of lysosomal storage diseases (LSDs)
This technology includes the generation and use of human induced pluripotent stem cell (iPSC) lines that can be used to study and screen potential therapeutics for lysosomal storage diseases (LSDs). LSDs are a group of 50 genetic disorders caused by mutations in the genes encoding lysosomal enzymes and proteins. Although various therapeutic approaches...
Published: 10/28/2024   |   Inventor(s): Miao Xu, Yu-Shan Cheng, Manisha Pradhan, Jizhong Zou, Jeanette Beers, Wei Zheng
Keywords(s): Cell, COMPOUND, DERIVED, Disease, iPS, Lines, Lysosomal, Modeling, PATIENT, screening, Storage, VPXXXX, WIXXXX, XHXXXX
Category(s): TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Ophthalmology, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, Application > Research Materials, ResearchProducts > Research Equipment
Monoclonal Antibodies To Prevent or Treat SARS-CoV-2 Infection
The ongoing COVID-19 pandemic, caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2), has created an immense public health, social, and economic burden. Variants of concern continue to emerge that have increased transmissibility, pathogenicity, or both and that reduce the effectiveness of current therapeutics and vaccines. Thus, there is...
Published: 10/28/2024   |   Inventor(s): Patrizia Farci, Kamille West, Peng Zhang, Paolo Lusso, Zhaochun Chen
Keywords(s): antibodies, Cure, Disease, monoclonal, Prevent, SARS-CoV-2
Category(s): Collaboration Sought > Collaboration
LRRK2 Inhibitors: Novel Treatment for Intestinal Bowel Disorders
Use of Leucine Rich Repeat Kinase 2 (LRRK2) inhibitors for the treatment of Intestinal Bowel Disorders (IBD) is disclosed. IBD is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. Crohn's disease and ulcerative colitis, two common forms of idiopathic IBD, are chronic, relapsing...
Published: 10/28/2024   |   Inventor(s): Tetsuya Takagawa, Atsushi Kitani, Warren Strober
Keywords(s): COLITIS, Crohn's, Disease, IB3XXX, inhibitor, LRRK2, TREAT, Ulcerative, VPXXXX, WKXXXX, XEXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, TherapeuticArea > Ophthalmology, TherapeuticArea > Immunology, TherapeuticArea > Oncology, TherapeuticArea > Cardiology
Treatment of Chronic Kidney Disease with Synthetic Amphipathic Peptides
The invention is directed to treatment of chronic kidney disease by administering a synthetic, amphipathic helical peptide known as 5A-37pA, and novel derivatives thereof. Scientists at NIDDK have demonstrated that invention peptides antagonize activity of a particular scavenger receptor known as CD36. Using an in vivo model, NIDDK scientists have shown...
Published: 10/28/2024   |   Inventor(s): Peter Yuen, Robert Star, Alexander Bocharov, Alan Remaley, Thomas Eggerman, Ana Souza
Keywords(s): 5A-37pA, AMPHIPATHIC, Chronic, Disease, HELICAL, KIDNEY, Peptide, treatment, VDXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VPXXXX, WIXXXX, WJXXXX, XHXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Oncology, ResearchProducts > Research Equipment, Application > Research Materials
Compositions and Methods for Improved Lyme Disease Diagnosis
This CDC-developed technology entails novel compositions and methods related to the diagnosis of Lyme disease. Lyme disease, caused by the Borrelia burgdorferi bacterium, is the most common tick-borne infectious disease in the US and Europe. Diagnosis of Lyme disease is particularly challenging as symptoms often appear long after exposure. At present,...
Published: 10/28/2024   |   Inventor(s): Theresa Russell, Barbara Johnson
Keywords(s): BACTERIA, BORRELIA BURGDORFERI, BORRELLIA, BURGDORFERI, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA3XXX, DAXXXX, diagnostic, Diagnostic assay, diagnostic in vitro, Disease, DXXXXX, ivd, LYME, Methods, Relating, TICK, TICK-BORNE, TICKS, Vector-borne, Vector-borne diseases, VETERINARY, VJXXXX, VOXXXX, WBXXXX, WCXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, XCXXXX, YBXXXX, Zoonotic
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Occupational Safety and Health, Application > Consumer Products, TherapeuticArea > Infectious Disease
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