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Title
ID
Descending
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A Pot
e
nt HIV Treatment with Low Toxicity
A small-mol
e
cule class that binds to HIV particles to improve immune response and block viral entry into cells. Problem: 37 million people worldwide currently live with HIV and an estimated 2-3 million new infections occur annually. While antiretroviral therapies do exist for those with the disease, therapy interruption leads to the re-emergence of...
Published: 10/30/2025
|
Inventor(s):
Amos Smith
,
Xuch
e
n Zhao
,
Tyl
e
r Higgins
,
Andr
e
s Finzi
,
Shil
e
i Ding
,
Dani
e
l Lee
,
Marz
e
na Pazgier
,
Dung Nguy
e
n
,
William Tolb
e
rt
Keywords(s):
Drug Targ
e
t
,
HIV/AIDS
,
Small Mol
e
cule
,
Soft Mat
e
rials
Category(s):
T
e
chnology Classifications > Chemical Processes and Synthesis
,
T
e
chnology Classifications > Therapeutics
Nov
e
l AKR1C3 Inhibitors in Cancer
Inhibitors and tools to block th
e
local formation of steroid hormones in hormone-dependent malignancies of the prostate, breast and endometrium Value Proposition: Standard treatment of care for hormone-dependent tumors utilizes hormone ablative therapies. These agents non-discriminately block the action of estrogens and androgens and have untoward side...
Published: 10/30/2025
|
Inventor(s):
Tr
e
vor Penning
,
Ad
e
goke Adeniji
,
Micha
e
l Byrns
,
J
e
ffrey Winkler
,
Barry Tw
e
nter
,
Lawr
e
nce Marnett
,
Andy Li
e
dtke
Keywords(s):
M
e
n's Health
,
Oncology
,
Small Mol
e
cule
,
Wom
e
n's Health
Category(s):
T
e
chnology Classifications > Therapeutics
T C
e
lls Targeting Misformed Proteins to Treat Neurodegenerative and Muscular Diseases
Antig
e
n-specific immunotherapy with engineered cytotoxic T cells targeting misformed proteins to treat neurodegenerative and muscular diseases. Problem: Neurodegenerative and muscular diseases, such as amyotrophic lateral sclerosis (ALS), inclusion body myositis (IBM), and Alzheimer’s disease (AD), collectively affect over 5 million adults...
Published: 10/30/2025
|
Inventor(s):
Ning J
e
nny Jiang
,
Shahab Chizari
Keywords(s):
Bio
e
ngineering
,
C
e
ll Therapy
,
Immunology
,
Immunoth
e
rapy
,
Inflammation
,
N
e
urodegenerative Diseases
Category(s):
T
e
chnology Classifications > Diagnostics
,
T
e
chnology Classifications > Research Tools & Reagents
,
T
e
chnology Classifications > Therapeutics
S
e
asonally-Adaptive Battery Thermal Management System for Electric Vehicles
Inv
e
ntion Description Electric vehicles are becoming more common, especially with the push for greater utilization of renewable energy. However, it is widely known that electric vehicles suffer from safety issues associated with mistreatment, collisions, and charging issues. Further, batteries in electric vehicles often have performance degradation...
Published: 10/30/2025
|
Inventor(s):
Moustafa Am
e
r
,
Mahmoud Shouman
,
Arunachala Kannan
,
Ahm
e
d Hamed
,
Moham
e
d Salem
Keywords(s):
Category(s):
Physical Sci
e
nce
,
Advanc
e
d Materials/Nanotechnology
,
E
nergy & Power
Th
e
rmal Performance Assessment and Management System for Lithium-Ion Batteries
Inv
e
ntion Description Technological breakthroughs in electric batteries have resulted in higher energy density batteries which have risks of overheating during high-rate charging and discharging. This leads to performance degradation, limiting battery lifespan and capacity and hindering widespread battery adoption. Battery management systems (BMSs)...
Published: 10/30/2025
|
Inventor(s):
Moustafa Am
e
r
,
Moham
e
d Salem
,
Arunachala Kannan
,
Ahm
e
d Hamed
,
Mahmoud Shouman
Keywords(s):
Category(s):
Advanc
e
d Materials/Nanotechnology
,
E
nergy & Power
,
Physical Sci
e
nce
Tr
e
atment for Dengue Virus (DENV) Infection
Application Antiviral th
e
rapeutic for multiple Dengue virus serotypes. Key Benefits Targets conserved regions of DENV genomes, enabling efficacy across serotypes. Mitigates lethal infections with a single lipid nanoparticle (LNP) based dose in mice. Minimal off-target effects. Market Summary Despite 390+ million annual DENV infections, there...
Published: 10/30/2025
|
Inventor(s):
Philip Santang
e
lo
,
Daryll Vanov
e
r
,
Chiara Zurla
,
Lor
e
na Carvalho de Souza Chaves
Keywords(s):
DNA and RNA Vaccin
e
s
,
Drug Discov
e
ry
,
Drug Targ
e
t Identification
,
Microbiology and Inf
e
ctious Disease Treatments
Category(s):
T
e
chPub Algolia > Therapeutics
Sph
e
rical Nucleic Acids with Sheddable PEG Layers
Sph
e
rical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting NU 2017-169 INVENTORS Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN)) Brian Meckes Wuliang Zhang SHORT DESCRIPTION For oncology applications,...
Published: 10/30/2025
|
Inventor(s):
Keywords(s):
Biologic
,
Biomark
e
r
,
Biom
e
dical
,
Canc
e
r/Oncology
,
Ch
e
micals
,
Diagnostics
,
Drug d
e
livery
,
Nanoparticl
e
,
Nanot
e
chnology
,
P
e
rsonalized medicine
,
Th
e
rapeutics
Category(s):
Lif
e
Sciences > Therapeutics
,
Lif
e
Sciences > Healthcare Devices, Tools & IT
,
Lif
e
Sciences > Biomarkers & Biomedical Research Tools
A lightw
e
ight wearable electrode array for electrooculography
Tracking
e
ye movement is integral for constructing virtual reality headsets, and in the healthcare sector, eye movement tracking is useful for diagnosing sleep disorders. Current iterations of commercial eye trackers mainly rely on visually tracking the wearer’s retina using head-mounted cameras. This approach suffers from many analytical limitations,...
Published: 10/30/2025
|
Inventor(s):
D
e
epak Ganesan
,
Trisha Andr
e
w
,
Ali Kiaghadi
,
S
e
yedeh Zohreh Homayounfar
,
Soha Rostaminia
Keywords(s):
Category(s):
D
e
vices & sensors
,
H
e
althcare
,
Mat
e
rial science
Cord Blood Prot
e
in Biomarkers to Identify Early-Onset Neonatal Sepsis
LNU 2024-090 INV
E
NTORS Leena Mithal* SHORT DESCRIPTION A diagnostic assay developed using proteomic biomarkers from umbilical cord blood to rapidly risk stratify newborns for early-onset neonatal sepsis, enabling targeted antibiotic therapy and improved outcomes. BACKGROUND Current approaches to diagnose early-onset sepsis rely on postnatal...
Published: 10/30/2025
|
Inventor(s):
Keywords(s):
Category(s):
Lif
e
Sciences > Therapeutics
TauS
e
eK: Disease Specific Tau Protein Fibrils & Seeding Proteins
NU 2024-154 INV
E
NTORS Songi Han* Austin Dubose Michael Vigers Andrew Longhini Vishnu Vijayan Kenneth Kosik Samuel Lobo Peter C. Ryffel Lokeswara Rao Potnuru Karen Tsay Chung-Ta Han SHORT DESCRIPTION Compositions, kits, and methods for generating synthetic miniature tau peptides and fibrils, and synthetic full-length pathogenic tau...
Published: 10/30/2025
|
Inventor(s):
Keywords(s):
Category(s):
Lif
e
Sciences > Therapeutics
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