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Search Results - interleukin
3
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Anti-bacterial Treatments Using Peptide-Based Inhibitors of the STAT3-IL10 Pathway
Abstract: Tuberculosis (TB) is an infectious disease that typically affects the lungs. Current therapies include a panel of antibiotics given over a range of 6-9 months. As a result of the expense of treatment, the extended timeframe needed for effective treatment, and the scarcity of medicines in some developing countries, patient compliance with TB...
Published: 4/8/2024
|
Inventor(s):
Nadya Tarasova
,
Mercedes Gonzalez-Juarreto
Keywords(s):
Anti-infective
,
IL-10
,
immunomodulatory
,
Immunotherapy
,
INTERLEUKIN
,
STAT3
,
TUBERCULOSIS
Category(s):
Application > Therapeutics
,
Collaboration Sought > Licensing
,
Collaboration Sought > Collaboration
,
TherapeuticArea > Immunology
,
TherapeuticArea > Infectious Disease
Peptide Inhibitors for Viral Infections and as Anti-inflammatory Agents
Abstract: IFN-gamma and IL-10 are cytokine signaling molecules that play fundamental roles in inflammation, cancer growth and autoimmune diseases. Unfortunately, there are no specific inhibitors of IFN-gamma or IL-10 on the market to date. NCI investigators at the Cancer and Inflammation Program have synthesized short peptides that selectively interfere...
Published: 4/8/2024
|
Inventor(s):
Nadya Tarasova
,
Giorgio Trinchieri
,
Howard Young
,
C. Andrew Stewart
,
Marco Cardone
,
Alan Perantoni
Keywords(s):
IFN-gamma
,
Interferon gamma
,
INTERLEUKIN
,
Peptide
,
Peptidometic
,
psoriasis
,
Synthetic Peptide Inhibitors
Category(s):
Collaboration Sought > Collaboration
,
TherapeuticArea > Dermatology
,
Collaboration Sought > Licensing
,
Application > Therapeutics
,
TherapeuticArea > Oncology
,
TherapeuticArea > Infectious Disease
,
TherapeuticArea > Immunology
Transgenic Human
Interleukin
-21 Mouse Model
Available for licensing is a mouse model that constitutively expresses human
interleukin
-21 (IL-21). Traditionally, human IL-21 transgenic mouse models are difficult to produce as those with high IL-21 levels exhibit growth retardation and die before sexual maturity. The investigators generated transgenic mice that express human IL-21, which can stimulate...
Published: 7/25/2024
|
Inventor(s):
Katsutoshi Ozaki
,
Warren Leonard
Keywords(s):
AC5XXX
,
ACXXXX
,
AXXXXX
,
CCXXXX
,
CXXXXX
,
IDXXXX
,
IL-21
,
INTERLEUKIN
,
interleukin
21
,
IXXXXX
,
Mice
,
Mouse
,
Mouse animal model
,
mouse model
,
TRANSGENIC
Category(s):
Collaboration Sought > Licensing
,
Application > Research Materials
,
Application > Diagnostics
,
TherapeuticArea > Oncology
,
Application > Therapeutics