Search Results - mass+spectrometry

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Acoustic Manipulation and Sampling of Lipids and Lipid Particles
­Advantages: Preservation of Lipid Integrity Native Mass Spectrometry (MS) Capability Versatility and Efficiency Summary: This innovative technology addresses a significant challenge in lipid analysis, setting it apart from conventional methods. By utilizing high-frequency surface acoustic waves (SAW) for mechanical disruption of lipid...
Published: 8/16/2024   |   Inventor(s): Theresa Evans-Nguyen, Venkat Bhethanabotla, Ashton Taylor, Yuqi Huang, Cheyenne Sircher
Keywords(s): Biotechnology, Diagnostics, Laboratory Methods, Mass Spectrometry
Category(s): Technology Classifications > Medical > Biomedical Engineering
METHODS RELATED TO AN ALTERNATIVE CONFORMATION OF THE SARS-COV-2 SPIKE PROTEIN
METHODS RELATED TO AN ALTERNATIVE CONFORMATION OF THE SARS-COV-2 SPIKE PROTEIN Researchers at UC Berkeley have developed methods to probe the conformational landscape of the SARS-CoV-2 Spike protein in the prefusion and ligand binding variations. The Spike protein from SARS-CoV-2 is the primary target for current vaccines against COVID-19 and is...
Published: 7/27/2023   |   Inventor(s): Susan Marqusee, Shawn Costello, Sophie Shoemaker
Keywords(s): Conformation, Mass Spectrometry, Modeling, Spike Protein, Structure
Category(s): Technology Classifications > Biology
MULTIMODE OMICS OF SINGLE TISSUE SAMPLE
MULTIMODE OMICS OF SINGLE TISSUE SAMPLE Researchers at UCSF have developed a method for multimode OMICs analyses of tissue sections using mass spectrometry imaging, spatial transcriptomics, and genomics on a shared sample. Currently, mass spec imaging based on MALDI MS is the best way to show the distribution of small chemicals or metabolites of tissues....
Published: 4/20/2023   |   Inventor(s): Adam Abate, Linfeng Xu
Keywords(s): Mass Spectrometry, Metabolomics, Spatial Barcoding, Tissue Sample, Tissue Section, Transcriptomics
Category(s): Technology Classifications > Biology
Absorbance-Coupled Voltage Control of Electrospray Ionization
Mass spectrometry (MS) is a widely used research tool for determining the exact molecular weight of particles within a sample. It separates electrically charged ions within a gas phase that are subsequently transferred into a mass analyzer, sorted in space or time according to their mass-to-charge ratios. Although there have been many advances using...
Published: 9/27/2024   |   Inventor(s): James Grinias, Samuel Foster, Deklin Parker, Christopher Piccolo
Keywords(s): Electrospray, Mass Spectrometry
Category(s): Research Tools
Improved Botulism, Botulinum Neurotoxin Type-E Diagnostics
CDC researchers have improved upon a prior, HHS patented mass spectrometry-based Endopep-MS assay that is able to rapidly detect and differentiate all seven botulinum neurotoxin (BoNT) types A to G. This current improvement comprises the addition of two optimized substrate peptides that increases the assay's sensitivity,relative to prior substrates,...
Published: 10/28/2024   |   Inventor(s): Suzanne Kalb, John Barr, Dongxia Wang
Keywords(s): AAXXXX, ACXXXX, BACTERIA, Bacterial, Biodefense, Biodetection, Bolulinum, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DA5XXX, DAXXXX, DXXXXX, e, MASS SPECTROMETER, Mass spectrometry, Neurotoxin, Novel, Peptide, Recognizable, SUBSTRATES, toxin, TYPE, VBXXXX, VJXXXX, VKXXXX, VLXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WIXXXX, WMXXXX, XCXXXX, XDXXXX, XHXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, Application > Consumer Products, Application > Non-Medical Devices, Application > Medical Devices, ResearchProducts > Research Equipment, Application > Research Materials, Application > Diagnostics, Application > Occupational Safety and Health
Tailored, Non-linear Signal Modulation for Encoding Information in Multiple Dimensions
Unmet Need: Fast, multidimensional analysis of the physical, chemical, and mechanical properties of gas-phase ions, molecules, and particles When coupling two or more stages of on-line or off-line analysis, the second stage of analysis must be much faster than the first to adequately sample information transmitted between dimensions. When the second...
Published: 10/17/2024   |   Inventor(s): Brian Clowers, Elvin Cabrera, David Russell, Arthur Laganowsky
Keywords(s): Ion Mobility Spectrometry, Mass Spectrometry, Signal Processing
Category(s): Technologies > Health & Well-being > Chemistry, Technologies > Energy & Environment > Instrumentation/Equipment
Diagnosis of lung cancer subtypes using rapid molecular test
New cancer subtyping system can improve treatment options without disrupting clinical workflow.Problem Lung cancer is the leading cause of cancer death, with over 100,000 people dying per year.1 As most tumors are inoperable by the time the cancer is detected, patients are increasingly being placed on tailored treatment regimens. Prescribing targeted...
Published: 11/1/2023   |   Inventor(s): Livia Eberlin, Erik Cressman, Alena Bensussan, John Lin, Chunxiao Guo, Savitri Krishnamurthy
Keywords(s): Cancer, Diagnostics, Machine learning, Mass spectrometry, Medical devices, Medical imaging, Minimally invasive
Category(s): Life sciences > Diagnostic
Early detection of cancer from blood draw
Problem Eight million people die from cancer each year, and 90% of these deaths happen in cases where the cancer has spread throughout the body from the initial tumor site.1 In the early stages of cancer, tumor cells can shed from the primary mass and enter the bloodstream. Clinicians can glean important information about the tumor from these circulating...
Published: 11/1/2023   |   Inventor(s): Livia Eberlin, Ruth Katz, Alena Bensussan, Tanweer Zaidi
Keywords(s): Cancer, Diagnostics, Mass spectrometry
Category(s): Life sciences > Diagnostic, Life sciences > Research tools > Tool/assay/screening platform
DNA Adductomics by Mass Tag Prelabeling
Background DNA adducts are damaged nucleotides in DNA as a consequence of its exposure to genotoxic agents or conditions. Measurement of multiple DNA adducts in a single procedure is referred to as “DNA adductomics”. In the leading analytical technique for this purpose, typically the following sequence of steps takes place starting with...
Published: 10/15/2024   |   Inventor(s): Roger Giese, Poguang Wang
Keywords(s): Cancer, cancer prevention, DNA adduct, Mass Spectrometry, Mass tags, personalized medicine
Category(s): -Cancer