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Search Results - joseph+derisi
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PERILIPIN-1 SPECIFIC T CELLS FOR SELECTIVE FAT TARGETING
Researchers at UCSF and CZ Biohub SF have described cells expressing a heterologous T-cell receptor, that binds to an adipose-specific protein perilipin 1 peptide complex, thereby enabling selecting targeting of fat cells. T cell tolerance is enforced in the thymus through the expression of a wide array of self proteins called tissue-specific antigens...
Published: 10/23/2025
|
Inventor(s):
Mark Anderson
,
Irina Proekt
,
Joseph DeRisi
Keywords(s):
Autoantibody
,
Autoimmune
,
Therapeutic
Category(s):
Technology Classifications > Biology
CHAGAS DISEASE SEROLOGY ANTIGEN
Researchers at CZ Biohub SF and UCSF have developed a novel diagnostic application for Chagas disease using a selective antigen. Chagas disease is an infection caused by the parasite Trypanosoma cruzi (T. cruzi). This disease is primarily endemic to Latin America but increasingly recognized in the United States, particularly among Latinx immigrant...
Published: 10/23/2025
|
Inventor(s):
Jeffrey Whitman
,
Joseph DeRisi
,
Caryn Bern
,
Jayant Rajan
,
Hannah Kortbawi
,
Ryan Marczak
Keywords(s):
Antigen
,
Diagnosis
,
Pathogen
Category(s):
Technology Classifications > Biology
METHODS, COMPOSITIONS, AND SYSTEMS TO DETECT NON-SMALL CELL LUNG CANCER
Researchers at CZ Biohub SF and UCSF have developed novel methods for the early detection of non-small cell lung cancer. Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths in the U.S., with many cases diagnosed at an advanced stage, significantly reducing survival rates. Although low-dose chest CT (LDCT) scans are effective...
Published: 10/23/2025
|
Inventor(s):
Chukwuka Didigu
,
Joseph DeRisi
,
David Jablons
,
Johannes Kratz
,
Andrew Kung
Keywords(s):
Cancer
,
Diagnosis
Category(s):
Technology Classifications > Biology
COMPOSITIONS AND METHODS RELATED TO TRANSCOBALAMIN RECEPTOR AUTOANTIBODIES
COMPOSITIONS AND METHODS RELATED TO TRANSCOBALAMIN RECEPTOR AUTOANTIBODIES Researchers at CZ Biohub SF and UCSF have developed methods and kits to detect autoantibodies targeting the transcobalamin receptor CD320, which is associated with neurological symptoms in certain patients, as well as methods to treat patients with this condition. Vitamin...
Published: 10/26/2023
|
Inventor(s):
John Pluvinage
,
Michael Wilson
,
Joseph DeRisi
,
Samuel Pleasure
Keywords(s):
Autoantibody
,
Brain
,
Vitamin B12
Category(s):
Technology Classifications > Biology
ANTIBODIES TO IL1RN AS MARKERS OF PRETERM BIRTH
ANTIBODIES TO IL1RN AS MARKERS OF PRETERM BIRTH Researchers at CZ Biohub SF and UCSF have discovered a novel biomarker of pre-term birth. Little is known about pre-term delivery risk and more specifically the immunological processes that allow for tolerance of a semi-allogenic fetus within the mother’s body. However, the processes that govern...
Published: 10/22/2025
|
Inventor(s):
Elze Rackaityte
,
Joseph DeRisi
Keywords(s):
Antibody
,
Biomarker
,
Preterm Delivery Risk
Category(s):
Technology Classifications > Biology
LOWER RESPIRATORY TRACT INFECTION DIAGNOSTICS
LOWER RESPIRATORY TRACT INFECTION DIAGNOSTICS Researchers at UCSF, CZ Biohub SF, CZI and University of Colorado have developed a host/pathogen classifier to differentiate patients with lower respiratory tract infections (LRTI) from those with non-infectious acute respiratory illnesses. Lower respiratory tract infections (LRTI) are a leading cause...
Published: 1/31/2025
|
Inventor(s):
Charles (Chaz) Langelier
,
Peter Mourani
,
John Kamm
,
Eran Mick
,
Alexandra Tsitsiklis
,
Katrina Kalantar
,
Lilliam Ambroggio
,
Joseph DeRisi
Keywords(s):
Disease Classifier
,
Pathogen
,
Respiratory
Category(s):
Technology Classifications > Biology
METHOD AND SYSTEM FOR LABEL-FREE IMAGING AND CLASSIFICATION OF MALARIA PARASITES
METHOD AND SYSTEM FOR LABEL-FREE IMAGING AND CLASSIFICATION OF MALARIA PARASITES Researchers at the CZ Biohub SF have developed an improved method of detecting and classifying malarial parasitemia in blood samples that is cost-efficient and readily able to be implemented in low-resource settings. Accurate, timely, and cost-effective diagnostics...
Published: 12/5/2024
|
Inventor(s):
Paul Lebel
,
Rafael Gómez-Sjöberg
,
Joseph DeRisi
,
Jenny Folkesson
Keywords(s):
Deep Learning
,
Diagnostics
,
Label-Free
,
Malaria
,
P. Falciparum
,
Visible Light Microscopy
Category(s):
Technology Classifications > Biology
AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY
AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY Researchers at UCSF and the Chan Zuckerberg Biohub have developed methods to identify a subject that is at risk of developing autoimmune-related lipodystrophy. Lipodystrophy is a clinical phenotype defined by a reduction in subcutaneous fat or adipose tissue. Excessive fat loss can lead to an imbalance...
Published: 12/5/2024
|
Inventor(s):
Caleigh Mandel-Brehm
,
Joseph DeRisi
,
Mark Anderson
Keywords(s):
Antibody
,
Autoantibody
,
Autoimmune
,
Biomolecules
,
Diagnosis
,
IgG
,
Immunotherapy
,
Lipodystrophy
Category(s):
Technology Classifications > Biology
AUTOANTIBODIES AS BIOMARKERS FOR AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 1
AUTOANTIBODIES AS BIOMARKERS FOR AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 1 Researchers at UCSF and the Chan Zuckerberg Biohub have identified multiple common autoantibody targets in APS1 patients through proteome-wide programmable phage-display. The identification of autoantigens remains a critical challenge for understanding and treating autoimmune...
Published: 10/26/2024
|
Inventor(s):
Sara Vazquez
,
Mark Anderson
,
Joseph DeRisi
Keywords(s):
Antibody
,
Autoantibody
,
Diagnosis
,
Particle Display
,
Serum
Category(s):
Technology Classifications > Biology
METHODS, COMPOSITIONS AND SYSTEMS FOR PROFILING OR PREDICTING IMMUNE RESPONSE
METHODS, COMPOSITIONS AND SYSTEMS FOR PROFILING OR PREDICTING IMMUNE RESPONSE Researchers at Avail Bio, Inc., UCSF and the Chan Zuckerberg Biohub have developed a proteomic technology for capturing the immune response against non-wild type antigens. Immuno-oncologic research demonstrating tumor recognition by the immune system has led to the development...
Published: 6/1/2023
|
Inventor(s):
Nima Emami
,
Clinton Cario
,
Joseph DeRisi
,
John Witte
Keywords(s):
Antibody
,
Cancer
,
Immunotherapy
,
Oncology
,
Particle Display
Category(s):
Technology Classifications > Biology
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