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Search Results - covid-19
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High-Throughput Approach to Identify New Lipid Nanoparticle Formulations for Vaccine and Drug Delivery
High-throughput in vivo screening method to identify lipid nanoparticle (LNP) formulations for local and systemic delivery for mRNA vaccines and cancer immunotherapies. Problem: Nucleic acid delivery is an attractive and rapidly growing area of research, particularly for the development of vaccines and cancer immunotherapy. Historically, viral vectors...
Published: 12/20/2024
|
Inventor(s):
Michael Mitchell
,
Alex Hamilton
Keywords(s):
Bioengineering
,
COVID-19
,
Drug Delivery
,
Gene Therapy
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Infectious Disease
,
Nanotechnology
Category(s):
Technology Classifications > Testing & Measurement
,
Technology Classifications > Vaccines
,
Technology Classifications > Therapeutics
Lipid Nanoparticles That Specifically Target The Lungs
Lung-targeting lipid nanoparticles allowing organ specific mRNA delivery for gene therapy applications. Problem: Gene therapy via mRNA delivery allows the rapid generation of therapeutics and vaccines for a wide range of applications. However, mRNA is especially vulnerable to degradation in the body, necessitating packaging within lipid nanoparticles....
Published: 10/17/2024
|
Inventor(s):
Michael Mitchell
,
Lulu Xue
Keywords(s):
Bioengineering
,
COVID-19
,
Gene Therapy
,
Infectious Disease
,
Pulmonary
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Therapeutics
,
Technology Classifications > Vaccines
Adjuvanted Lipid Nanoparticles (LNPs) Enhance Protective Immunity Imparted by SARS-CoV-2 mRNA Vaccine
A lipid nanoparticle formulation that elicits a strong innate immune response for improved vaccine protection Problem: Lipid nanoparticle (LNP)-formulated mRNA vaccines have revolutionized modern vaccinology through their ability to deliver mRNA vaccines with remarkable manufacturing flexibility. However, the modified (pseudouridylated) mRNA used in...
Published: 10/1/2024
|
Inventor(s):
Michael Mitchell
,
Xuexiang Han
,
Drew Weissman
,
Mohamad Alameh
Keywords(s):
Bioengineering
,
COVID-19
,
Drug Delivery
,
Immunology
,
Infectious Disease
,
Nanotechnology
Category(s):
Technology Classifications > Materials
,
Technology Classifications > Vaccines
Combination Therapy to Treat Viral Acute Respiratory Distress Syndrome (ARDS)
Advantages: PG’s anti-inflammatory effects mitigate viral inflammation of
COVID-19
. Intranasally administered mesenchymal stem cells (MSCs) create an anti-inflammatory microenvironment and can enhance neuro-regenerative effects. Targets viral transmission and neuronal damage to reduce virus-induced neuronal damage, and mortality, and...
Published: 7/15/2024
|
Inventor(s):
Subhra Mohapatra
,
Shyam Mohapatra
,
Mahasweta Das
,
Andrew McGill
,
Karthick Mayilsamy
Keywords(s):
Covid-19
,
Respiratory Diseases Treatment
Category(s):
Technology Classifications > Medical > Respiratory
Low-Cost, Point-of-Care Test for Rapid Visual Diagnosis of
COVID-19
A rapid, low-cost, portable swab-based SARS-CoV-2 biosensor whose test result can be detected with naked eye Problem:
COVID-19
has killed over 2.84 million people worldwide and has disproportionately affected people in lower-income and resource-limited geographies. High-frequency testing can prevent rapid virus spread and reduce COVID-19-related hospitalizations...
Published: 6/26/2024
|
Inventor(s):
Cesar de la Fuente-Nunez
,
Marcelo Der Torossian Torres
,
Lucas Felipe de Lima
,
Andre Lopes Ferreira
Keywords(s):
Bioengineering
,
COVID-19
,
Infectious Disease
Category(s):
Technology Classifications > Diagnostics
,
Technology Classifications > Medical Devices
Targeted Lentiviral Transduction of B-Cells With Desired B-Cell Receptor Specificity (UCLA Case No. 2023-237)
UCLA researchers in the Division of Hematology and Oncology in the Department of Medicine, have discovered novel lentiviral vectors that can be used for gene delivery to B-cells and for the development of neutralizing antibodies against viruses. BACKGROUND: Microbial tropism is a microbiology term that describes the types of animals (including human),...
Published: 3/15/2024
|
Inventor(s):
Kouki Morizono
Keywords(s):
B Cell
,
cell receptor
,
COVID-19
,
VIral entry
,
Virus
Category(s):
Therapeutics > Immunology And Immunotherapy
IMMUNOGENIC CORONAVIRUS FUSION PROTEINS AND RELATED METHODS
IMMUNOGENIC CORONAVIRUS FUSION PROTEINS AND RELATED METHODS Researchers at Stanford have developed fusion proteins as a novel vaccine strategy for SARS-CoV2. As the causative force of the
COVID-19
pandemic, SARS-CoV2 caused massive sustained morbidity, mortality, and societal disruption worldwide. Though COVID-19 has largely transitioned from...
Published: 12/3/2024
|
Inventor(s):
Peter Kim
,
Natalia Friedland
,
Mrinmoy Sanyal
,
Payton Weidenbacher
Keywords(s):
Coronavirus
,
COVID
,
COVID-19
,
Infectious Disease
,
Vaccine
Category(s):
Technology Classifications > Biology
Tempol as a Therapeutic to Treat
Covid-19
Via Inhibition of Viral Replication
Abstract: Despite several partially effective prophylactic vaccines for SARS-CoV-2 exist, patients worldwide still succumb to
COVID-19
. New therapeutics to treat this disease are still needed. Upon host invasion, a critical step in the pathogenesis of COVID-19 is intracellular replication of SARS-CoV-2 before viral particles invade nearby healthy cells....
Published: 4/8/2024
|
Inventor(s):
Tracey Rouault
,
William Linehan
,
Nunziata Maio
Keywords(s):
ANTIVIRAL
,
COVID-19
,
RdRP Inhibitor
,
RNA-dependent RNA Polymerase inhibitor
,
Rouault
,
SARS-CoV-2
,
Tempol
Category(s):
TherapeuticArea > Infectious Disease
,
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
Application > Therapeutics
,
TherapeuticArea > Immunology
RNASEH-Assisted Detection Assay for RNA
Abstract: Several viral epidemics – such as the epidemics caused by H1N1 influenza virus, human immunodeficiency virus (HIV), Ebola virus, Zika virus, severe acute respiratory syndrome (SARS) virus, Middle East respiratory syndrome (MERS) virus and SARS-CoV-2 – have profoundly impacted global human health. Early identification of infected and/or infectious...
Published: 8/14/2024
|
Inventor(s):
G Esta Sterneck
,
Dipak Poria
Keywords(s):
COVID
,
COVID-19
,
INFLUENZA
,
Poria
,
RNA
,
RNASEH
,
SARS-CoV2
,
Sterneck
,
Viral RNA
Category(s):
Collaboration Sought > Licensing
,
Application > Diagnostics
,
TherapeuticArea > Infectious Disease
,
Collaboration Sought > Collaboration
Sensitive and Economic RNA Virus Detection Using a Novel RNA Preparation Method
Abstract: DNA or RNA-based diagnostic tests for infectious diseases are critical in modern medicine. The current gold standard for
COVID-19
detection is testing SARS-CoV-2 viral RNA by quantitative reverse transcription Polymerase Chain Reaction (RT-qPCR). This method involves patient sample collection with a nasopharyngeal swab, storage of the swab...
Published: 4/8/2024
|
Inventor(s):
Bin Guan
,
Robert Hufnagel
Keywords(s):
Biomarker
,
Chelating Resin
,
Chelex Resin
,
COVID
,
COVID-19
,
DNA/RNA diagnostic test
,
Extraction-free Detection
,
Infectious Diseases
,
SARS-CoV-2
,
virus
Category(s):
TherapeuticArea > Oncology
,
Application > Diagnostics
,
Collaboration Sought > Collaboration
,
TherapeuticArea > Infectious Disease
,
Collaboration Sought > Licensing
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