Search Results - pathogens

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Nucleic Acid Detection of the Fungal Pathogen Histoplasma capsulatum from Clinical and Environmental Samples
This invention relates to detecting Histoplasma capsulatum by PCR using oligonucleotide probes specific for the fungus. Histoplasmosis is a mycotic infection of varying severity, usually localized in the lungs. Caused by H. capsulatum, infections are usually symptomatic but can develop into chronic disease, especially in immunocompromised individuals. Test...
Published: 10/28/2024   |   Inventor(s): Thomas Reid, Millie Schafer
Keywords(s): AA5XXX, AAXXXX, AIDS, assay, Avian, AXXXXX, CAPSULATUM, CDC, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DAXXXX, DETECTING, Detection, diagnostic, DXXXXX, FUNGAL, FUNGI, fungus, HISTOPLASMA, Histoplasmosis, HIV, Method, NESTED, NIOSH-DART, Nucleic, nucleic acid, NUCLEIC ACID DETECTION, PATHOGEN, PATHOGENIC, PATHOGENS, PCR, PCR ASSAY, RAPID, SENSITIVE, VKXXXX, VOXXXX, VPXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, WMXXXX, XCXXXX, XEXXXX, XHXXXX, XIXXXX, YBXXXX, Zoo, Zoonotic
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, TherapeuticArea > Oncology, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Ophthalmology, Application > Occupational Safety and Health, Application > Therapeutics
Real-time PCR Multiplex Assay for Detection of Bacterial Respiratory Pathogens in Clinical Specimens
CDC researchers have developed a single-tube, real-time PCR assay for the simultaneous detection of three bacterial respiratory pathogens (Mycoplasma pneumoniae, Chlamydiophila pneumoniae and Legionella spp.). The assay has an internal control testing for presence of human DNA. This four-plex real-time PCR assay could potentially become a routine screening...
Published: 10/28/2024   |   Inventor(s): Agnes Warner, Kathleen Thurman, Jonas Winchell
Keywords(s): AA5XXX, AAXXXX, assay, AXXXXX, Bacterial, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, Detection, DXXXXX, Multiplex, OID-NCIRD-DBD, PATHOGENS, PCR, REAL, respiratory, TIME
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Infectious Disease
Multiplex Real-time PCR Assay for Detection of Numerous Bacterial Pathogens
In order to address a global need for rapid, cost-effective, sensitive, and specific assays for many pathogens, CDC scientists have developed a broad-use, multiplexed RT-PCR assay. This comprehensive assay covers numerous pathogens that are common causes of infection in neonates and also important to food-safety. Specifically, this assay (and respective...
Published: 10/28/2024   |   Inventor(s): Bernard Wolff, Maureen Diaz, Jonas Winchell
Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, Detection, DXXXXX, PATHOGENS, PCR, REAL-TIME
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics
Use of Modified Peptide Nucleic Acids for Visualizing DNA
The compounds described in this technology may be useful in the development of nucleic acid detection kits for various pathogens. Technologies for genomic detection most commonly use DNA probes to hybridize to target sequences, and require the use of Polymerase Chain Reaction (PCR) to amplify target sequences. Replacing the DNA probe with peptide nucleic...
Published: 10/28/2024   |   Inventor(s): Daniel Appella
Keywords(s): 2, Acid, Acids, Anthrax, APPLICATIONS, Cross-Coupled, Cyclopentan, Detection, Diamine-modified, Gamma-lysine, Modified, Nucleic, Patent Category - Chemistry, PATHOGENS, Peptide, Probes, SARS, Severe acute respiratory syndrome, Synthesis, Trans-1, YXXXXX
Category(s): Collaboration Sought > Collaboration
MAMA Real-Time PCR Assay Panel for Genotyping Cyrptococcus gattii
Researchers at TGen and Northern Arizona University (NAU) have developed methods for genotyping Cryptococcus gattii using a mismatch amplification mutation assay (MAMA) real-time PCR assay panel. This assay panel provides a rapid method for genotyping of C. gattii molecular types VGI-VGIV and the dominate North American VGII molecular subtypes VGIIa-c...
Published: 6/24/2024   |   Inventor(s): David Engelthaler, Elizabeth Driebe, Erin Kelley, Paul Keim
Keywords(s): Pathogens
Category(s): Genomics/Genetics, Diagnostics
Repurposed Drugs for the Treatment of Fungal Infections Caused by Coccidioides
Researchers at TGen and Northern Arizona University (NAU) have developed an effective treatment for fungal infections caused by Coccidioides including the Valley Fever-causing species: Coccidioides immitis and Coccidioides posadasii in humans and companion animals (particularly canines). Repurposed drugs originally developed to inhibit hormone uptake...
Published: 6/24/2024   |   Inventor(s): David Engelthaler, Elizabeth Driebe, Hongwei "Holly" Yin, Michael Valentine, Donald Chow, Jolene Bowers, Paul Keim
Keywords(s): Animal Health, Pathogens, Veterinary Medicine
Category(s): Therapeutics