Search Results - george+carlone

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Peptide Sequences for Chlamydophila pneumoniae Vaccine and Serological Diagnosis
CDC researchers have isolated select Chlamydophila pneumoniae peptide epitopes for development of vaccines and diagnostic assays. Currently, C. pneumoniae infection of humans has been linked to a wide variety of acute and chronic diseases, such as asthma, endocarditis, atherosclerotic vascular disease, chronic obstructive pulmonary disease, sarcoidosis,...
Published: 10/28/2024   |   Inventor(s): Jacquelyn Sampson, George Carlone, Edwin Ades, Eric Marston
Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, Chlamydophila, DA3XXX, DAXXXX, DC1XXX, DC4XXX, Diagnosis, DXXXXX, OID-NCIRD-DBD, Peptides, PNEUMONIAE, Serologic, SEROLOGICAL, Vaccine, VJXXXX, WBXXXX, WFXXXX, WJXXXX, XAXXXX, XCXXXX, XEXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, ResearchProducts > Antibodies, Application > Research Materials, TherapeuticArea > Immunology, Application > Diagnostics, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Occupational Safety and Health, Application > Therapeutics, Application > Vaccines
Methods for the Simultaneous Detection of Multiple Analytes
CDC researchers have developed a method of simultaneously detecting and distinguishing multiple antigens within a biological sample. Epidemiological and vaccine studies require species serotype identification. Current methods of serotyping are labor intensive and can easily give subjective, errant results. This technology utilizes serotype specific...
Published: 10/28/2024   |   Inventor(s): George Carlone, Joseph Martinez
Keywords(s): AA5XXX, AAXXXX, ANALYTES, AXXXXX, Bead, Beads, CA1BXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA1XXX, DA2XXX, DA3XXX, DA4AXX, DA4BXX, DA4XXX, DA5XXX, DAXXXX, Detection, flow cytometer, flow cytometry, IAXXXX, IMMUNOASSAY, Methods, MULTIPLE, SIMULTANEOUS, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WIXXXX, WMXXXX, XAXXXX, XCXXXX, XHXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, TherapeuticArea > Oncology, Application > Consumer Products, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment, Application > Research Materials, Application > Diagnostics, ResearchProducts > Antibodies, Application > Occupational Safety and Health
Multi-Antigenic Peptide(s) Vaccine and Immunogen for Conferring Streptococcus pneumoniae Immunity
Disease caused by Streptococcus pneumoniae (pneumococcus) is an important cause of morbidity and mortality in the United States and developing countries. Pneumococcal disease is prevalent among the very young, the elderly and immunocompromised individuals. This invention is an improved, immunogenic peptide construct consisting of a combination of...
Published: 10/28/2024   |   Inventor(s): George Carlone, Jacquelyn Sampson, Scott Johnson, Danny Jue, Edwin Ades
Keywords(s): Against, ANTIGENIC, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, DC4XXX, DCXXXX, DXXXXX, Epitope, Immunogenic, MULTIPLE, OID-NCIRD-DBD, Peptides, PNEUMONIA, PNEUMONIAE, Streptococcus, VJXXXX, VPXXXX, WBXXXX, WFXXXX, WIXXXX, WJXXXX, XAXXXX, XCXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Ophthalmology, Application > Diagnostics, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, Application > Consumer Products, Application > Research Materials, TherapeuticArea > Cardiology, Application > Therapeutics, Application > Occupational Safety and Health, ResearchProducts > Antibodies, TherapeuticArea > Immunology, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease
Peptide Vaccines Against Group A Streptococci
This invention relates to synthetic immunoreactive peptides, which are portions of the M proteins of the most prevalent Group A Streptococcus (GAS) serotypes in the United States. These peptides may be useful in development of a flexible, multivalent GAS vaccine. They can be recognized by M type-specific antibodies and are capable of eliciting functional...
Published: 10/28/2024   |   Inventor(s): George Carlone, Jacquelyn Sampson, Edwin Ades, Bernard Beall
Keywords(s): Against, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DC4XXX, DCXXXX, GROUP, OID-NCIRD-DBD, Peptide, Streptococci, vaccines
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease
Method of Enhancing Opsonophagocytosis
This invention aims to bolster the human body's own mechanisms to fight infection by enhancing an innate immune response, opsonophagocytosis. The specific 24 amino acid sequence (P4) acts as a polymorphonuclear cell activator. P4 can be administered in vivo along with a disease's specific antibody to enhance systemic bacterial clearance, thus leading...
Published: 10/28/2024   |   Inventor(s): GowriSankar Rajam, Sandra Steiner, George Carlone, Nikkol Atwell-Melnick Melnick, Jacquelyn Sampson, Joseph Martinez, Joseph Caba, Edwin Ades
Keywords(s): ANTIGEN, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, DB3XXX, DB5XXX, DBXXXX, DC1XXX, DC4XXX, DCXXXX, DXXXXX, ENHANCING, Epitopes, FUNCTIONAL, Listed LPM Surabian as of 4/15/2015, Methods, OID-NCIRD-DBD, Opsonophagocytosis, PATHOGEN, PNEUMONIAE, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PsaA, RESPONSE, Streptococcus, THEREOF, USES
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease
Real-time PCR Assay for Detection of Pneumococcal DNA and Diagnosis of Pneumococcal Disease
CDC scientists have developed a real-time PCR assay for diagnosing pneumococcal disease using amplification of the bacterial gene encoding pneumococcal surface adhesin A (PsaA). Pneumococcal isolation and identification is often complicated by 1) antimicrobial suppression of growth in culture and 2) contamination by normal flora alpha-streptococci....
Published: 10/28/2024   |   Inventor(s): Edwin Ades, George Carlone, Karen McCaustland, Maria Da Gloria Carvalho, Jacquelyn Sampson
Keywords(s): assay, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, Detection, Development, Diagnosis, Disease, DNA, DXXXXX, PCR, PNEUMOCOCCAL, REAL-TIME
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics