Search Results - shelley+haydel

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System for Reversible Control of Morphotype Switching in Mycobacterium abscessus for Enhanced Disease Modeling and Therapeutic Research

Invention Description Antibiotic-resistant nontuberculous mycobacteria (NTM) infections are increasing at ~8% annually, placing a significant burden on healthcare systems. Mycobacterium abscessus (Mabs) represents one of the most treatment-refractory pathogens, particularly in cystic fibrosis (CF) patients. Mabs disease severity is strongly associated...

Published: 2/26/2026 | Updated: 2/18/2026 | Inventor(s): Shelley Haydel, Rodrigo Aguilera Olvera, Lexi Yakimovich

Keywords(s): Antibiotic Resistance Treatments, Antibiotic Resistant Bacteria, CRISPR-Cas, Gene Expression, Infectious Disease, Microbes, bacteria, fungi, virus, yeast, Microbiology, Mycobacteria, mycobacterial genetics, Pathogen

Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Nucleic Acid/Peptide/Protein Therapies

Rapid Tuberculosis and Mycobacteria Phenotypic Drug Susceptibility Testing

Mycobacterium tuberculosis (TB) remains a major global health threat, causing nearly 1.5 million deaths annually, making it the 13th leading cause of death. While TB is preventable and treatable, multidrug-resistant TB worsens the global health crisis, making diagnosis and treatment more complex. An even greater challenge is heteroresistance, where...

Published: 2/26/2026 | Updated: 4/8/2025 | Inventor(s): Shelley Haydel, Shaopeng Wang, Jiapei Jiang, Yannik Haller

Keywords(s):

Category(s): Artificial Intelligence/Machine Learning, Vaccines/Antimicrobials, Life Science (All LS Techs), Imaging, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices

Novel, Synthetic, Antimicrobial Peptides

Owing to an increasing number of drug resistant bacteria, as well as similarity in the activity spectrum of current antibiotics, there is high demand for developing effective and specific antimicrobial therapies. Nontuberculous mycobacteria, specifically Mycobacterium abscessus (M. abscessus), have become an increasing public health concern in...

Published: 2/26/2026 | Updated: 1/7/2022 | Inventor(s): Shelley Haydel, Chris Diehnelt

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Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals, Vaccines/Antimicrobials

Isolating High-Quality RNA from Cells Exposed to Soils, Clays, or Metal Ion Solutions

Microarrays and high-throughput transcriptomic analyses require high quality RNA samples for accurate results. Extracting high quality RNA is notoriously difficult and can be further complicated by high clay or metal ion concentrations. Nucleic acids are difficult to separate from clay particles and metal ions may bind irreversibly to RNA and cause...

Published: 2/26/2026 | Updated: 2/26/2020 | Inventor(s): Andrea Loes, Shelley Haydel

Keywords(s):

Category(s): Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)