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WR (Western Reserve) Strain of Vaccinia Virus with K151E Mutation in A34R Gene

Mutation in gene A34R can regulate the release of progeny virions from the surface of parental cells.

Published: 10/28/2024 | Inventor(s): Rafael Blasco, Bernard Moss

Keywords(s): A34, AC4XXX, AC5XXX, ACXXXX, AXXXXX, Cell, DDXXXX, DISSOCIATION, DXXXXX, GCXXXX, GLYCOPROTEIN, MEMBRANE, Progeny, REGULATED, research, RESEARCH MATERIAL, research reagent, RESEARCH TOOL, RM, RXXXXX, vaccinia, viral, virus, WIXXXX, XEXXXX, XKXXXX

Category(s): Collaboration Sought > Licensing, Application > Vaccines, Application > Therapeutics, Application > Research Materials, TherapeuticArea > Infectious Disease

Adaptor for Suspending a Cryovial Over a Centrifuge Tube

The invention pertains to a device and system for expediting the thawing of frozen specimens (e.g., cryopreserved cells) contained in cryo-vials. An adaptor support suspends cryo-vials over a centrifuge tube containing culture medium in an inverted position. The adaptor has an elongated tubular body. While relatively basic, the adaptor dramatically...

Published: 4/8/2024 | Inventor(s): Margaret Beddall, Pratip Chattopadhyay, Mario Roederer

Keywords(s): AC3XXX, AC4XXX, AC6XXX, ADAPTER, AFXXXX, Cells, Cryopreservation, Cryopreserved, Cryo-sample, FROZEN, Listed LPM Shmilovich as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Thawing, WIXXXX, WMXXXX, XDXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Application > Consumer Products, Application > Non-Medical Devices, Application > Medical Devices, Application > Research Materials

Microscopy System for Distinguishing Stimulated Emissions as a Means of Increasing Signal

The invention pertains to a system and method for distinguishing stimulated emissions as a means of enhancing signal strength of fluorescent markers in fluorescence microscopy applications. The system is arranged such that an excitation beam (e.g., laser beam) illuminates a sample along some axis exciting the fluorescent markers used in the sample....

Published: 10/28/2024 | Inventor(s): Sanjay Varma, Andrew York

Keywords(s): AC1XXX, AC3XXX, AC4XXX, Distinguishing, Emission, Fluorescence, Increasing, MEANS, MICROSCOPY, Signal, STIMULATED, WMXXXX, XDXXXX, XFXXXX, XGXXXX, YAXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Application > Medical Devices, Application > Software / Apps, Application > Research Materials, Application > Diagnostics, Application > Non-Medical Devices, Application > Therapeutics, Application > Consumer Products

Focused Electrostatic Collection of Aerosol Particles for Chemical Analysis by Spectroscopic Techniques

This CDC-developed technology is an aerosol preconcentration unit (APU) designed for use with spectroscopic detection techniques, including emission, Raman, or infrared spectroscopies. Most existing pulsed microplasma techniques, such as laser-induced breakdown, for aerosols rely mainly on filter-based collection and suffer from poor accuracy, precision,...

Published: 10/28/2024 | Inventor(s): Prasson Diwakar, Pramod Kulkarni

Keywords(s): AA2XXX, AA3AXX, AA3B5X, AA3CXX, AA3XXX, AC1XXX, AC3XXX, AC4XXX, AC6XXX, ACXXXX, ADXXXX, AE2AXX, AE2XXX, AE3XXX, AE4XXX, AEROSOL, AEXXXX, AG1XXX, ANALYSER, ANALYSES, analysis, apparatus, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DAXXXX, DEVICE, DXXXXX, IA5XXX, IDXXXX, Method, NIOSH, NIOSH-DART, OID-NCIRD-DVD, optical, PLASMA, SPECTROSCOPY, TECHNIQUE, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WEXXXX, WFXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XFXXXX, XGXXXX, XHXXXX, XIXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Medical Devices, ResearchProducts > Research Equipment, Application > Research Materials, Application > Occupational Safety and Health, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, Application > Consumer Products, TherapeuticArea > Oncology, TherapeuticArea > Pulmonology, Application > Non-Medical Devices, TherapeuticArea > Infectious Disease, Application > Software / Apps, TherapeuticArea > Cardiology

Computer Controlled Aerosol Generator with Multi-Walled Carbon Nanotube Inhalation Testing Capabilities

This invention pertains to a CDC developed sonic aerosol generator that provides a controllable, stable concentration of particulate aerosol over a long period of time for aerosol exposure studies. Specifically, in situ testing data indicate uniform aerosol stability can be maintainable for greater than 30 hours at concentrations of 15 mg/m3 or more....

Published: 10/28/2024 | Inventor(s): David Frazer, Bean Chen, Walter McKinney

Keywords(s): AC1DXX, AC1XXX, AC4XXX, ACXXXX, AE1BXX, AE1XXX, AE2BXX, AE3XXX, AEROSOL, AEXXXX, AG2XXX, AG3XXX, AGXXXX, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DEVICE, ENVIRONMENTAL, environmental health, GENERATOR, nanotechnology, Nanotube, NIOSH, NIOSH-HELD, PARTICULATE, TOXICOLOGICAL, TOXICOLOGY, VPXXXX, WCXXXX, WFXXXX, WGXXXX, WHXXXX, WIXXXX, WMXXXX, WORK, WORKER safety, XDXXXX, XGXXXX, XIXXXX, XJXXXX, YBXXXX, YCXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Medical Devices, Application > Research Materials, Application > Occupational Safety and Health, ResearchProducts > Computational models/software, TherapeuticArea > Cardiology, Application > Therapeutics, TherapeuticArea > Ophthalmology, Application > Software / Apps, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Application > Non-Medical Devices

Novel In Vitro Granuloma Model for Studying Tuberculosis and Drug Efficacy

CDC researchers have developed an in vitro model system designed to simulate early-stage Mycobacterium tuberculosis infection and induced granuloma formation. This modeling platform can be used for studying tuberculosis pathogenicity, identifying phenotypically-interesting clinical isolates, studying early-stage host cytokine/chemokine responses, and...

Published: 10/28/2024 | Inventor(s): Manon Deslauriers, Kristin Birkness, Peter King, Bernard Beall, Frederick Quinn

Keywords(s): AC4XXX, AC5XXX, ACXXXX, ANTIGENS, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, DC4XXX, DCXXXX, DDXXXX, DEXXXX, diagnostic, DXXXXX, Granuloma, Human, IA3XXX, Identification, Latent, Methods, Model, OID-NCHHSTP-DTE, TUBERCULOSIS, Vitro, VJXXXX, WBXXXX, WFXXXX, WIXXXX, WMXXXX, XHXXXX, YBXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Consumer Products, Application > Occupational Safety and Health, ResearchProducts > Research Equipment, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics

Methods of Retaining Methylation Pattern Information in Globally Amplified DNA

CDC researchers have developed a novel method that generates globally amplified DNA copies retaining parental methylation information; making accurate DNA-archiving for methylation studies much more feasible and cost-effective than undertaking such an endeavor with alternate technologies. This unique approach eliminates a significant bottleneck in...

Published: 10/28/2024 | Inventor(s): Elizabeth Unger, Mangalathu Rajeevan

Keywords(s): AA5XXX, AAXXXX, AC4XXX, AC5XXX, AC6XXX, ACXXXX, AG2XXX, Amplified, AXXXXX, CC1XXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DA2XXX, DA3XXX, DA4AXX, DA4BXX, DA4XXX, DA5XXX, DAXXXX, DDXXXX, DNA, GAXXXX, GCXXXX, Globally, Method, Methylation, NA2BXX, NC3XXX, NC4XXX, NC5XXX, OID-NCEZID-DHCPP, Pattern, RETAINING, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VNXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WIXXXX, WMXXXX, XBXXXX, XCXXXX, XEXXXX, XHXXXX, YBXXXX

Photoinduced Electron Transfer Fluorescent Primer for Nucleic Acid Amplification

CDC scientists have developed a rapid and cost-efficient method for generating fluorescently labeled primers for PCR and real-time PCR. At present, fluorescent primers are useful for detecting and identifying microbes and specific nucleic acid sequences, amplifying nucleic acids for pyro-sequencing, determining the levels of gene expression, and many...

Published: 10/28/2024 | Inventor(s): Vincent Hill, Brian Holloway, Jothikumar Narayanan

Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC4XXX, AC5XXX, AC6XXX, Acid, ACXXXX, AE1BXX, AG1XXX, amplification, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, ELECTRON, Nucleic, OID-NCEZID-DFWED, PET, PHOTOINDUCED, PRIMER, TRANSFER, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VNXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WHXXXX, WIXXXX, WMXXXX, XBXXXX, XCXXXX, XEXXXX, XHXXXX, YBXXXX

Fluorescent Primer(s) Creation for Nucleic Acid Detection and Amplification

CDC researchers have developed technology that consists of a simple and inexpensive technique for creating fluorescent labeled primers for nucleic acid amplification. Fluorescent chemical-labeled probes and primers are extensively used in clinical and research laboratories for rapid, real-time detection and identification of microbes and genetic sequences....

Published: 10/28/2024 | Inventor(s): Vincent Hill, Jothikumar Narayanan

Keywords(s): AA5XXX, AAXXXX, AC3XXX, AC4XXX, AC5XXX, Acid, ACXXXX, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Detection, Nucleic, OID-NCEZID-DFWED, PRIMER, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VNXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WIXXXX, XBXXXX, XEXXXX, XHXXXX, YBXXXX

Device to Measure Muscle Contractile-Relaxant and Epithelial Bioelectric Responses of Perfused, Intact Tracheal Airways Tissue In Vitro

CDC and collaborative researchers have developed a device allowing for simultaneous measurement of smooth muscle contractile/relaxant activity and transepithelial potential difference (Vt) [or short circuit currents (Isc)] and resistance (Rt) within an intact airway in vitro. Investigation of the underlying mechanisms of lung diseases, such as asthma...

Published: 10/28/2024 | Inventor(s): Yi Jing, Michael Van Scott, Jeffrey Fedan

Keywords(s): AA2XXX, AAXXXX, AC4XXX, AC5XXX, ACXXXX, apparatus, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, CHARACTERISTICS, ICXXXX, IDXXXX, INTACT, IXXXXX, Measuring, Method, PHYSIOLOGICAL, Trachea, Vitro, VPXXXX, WBXXXX, WIXXXX, WMXXXX, XDXXXX, XHXXXX, YAXXXX, YBXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Medical Devices, TherapeuticArea > Oncology, ResearchProducts > Research Equipment, Application > Research Materials, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Dental, Application > Diagnostics, TherapeuticArea > Endocrinology, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, Application > Non-Medical Devices

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