Search Results - infectious+diseases

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Anti C. difficile Recurrence Vaccine Targeting Spore Colonization
Advantages Targets spore colonization, the root cause of CDI recurrence Broad coverage across diverse C. difficile strains Demonstrated protection in mice (reduced disease severity, toxins, and spore burden) Flexible delivery as injectable protein or oral L. lactis, enabling systemic + gut‑level immunity Summary Clostridioides difficile remains...
Published: 2/17/2026   |   Inventor(s): Xingmin Sun, Lubem Agbendeh, Soumyadeep Chakraborty
Keywords(s): Infectious Diseases, Vaccines
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Therapeutics
Generation of a single-chain recombinant IgA1 isotype antibody compatible with in vivo nucleic acid delivery for the treatment and prevention of flavivirus infection
This technology uses a single-chain IgA1 antibody delivered by DNA or RNA to enable the body to produce its own protection against dengue and Zika viruses, offering rapid, safe, and scalable prevention and treatment without risk of antibody-dependent enhancement. Background: Flavivirus infections, including those caused by dengue and Zika viruses,...
Published: 2/17/2026   |   Inventor(s): Adam Waickman, Stephen Thomas
Keywords(s): antibody therapy, infectious diseases, nucleic acid, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Antibodies, Technology Classifications > Healthcare
Use of recombinant IgA1 isotype mAbs to prevent and antagonize transplacental transmission of flaviviruses in pregnant women
This technology is a single-chain IgA1 antibody delivered by DNA or RNA, enabling the body to produce its own dengue-neutralizing antibodies safely and quickly, without the risk of worsening infection, for rapid prevention and treatment of flavivirus diseases. Background: The field of flavivirus therapeutics, particularly for diseases like dengue,...
Published: 2/17/2026   |   Inventor(s): Adam Waickman, Stephen Thomas
Keywords(s): infectious diseases, monoclonal antibodies, pregnancy, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Antibodies, Technology Classifications > Healthcare
Multiplexed Saliva-based Immunodiagnostics for Assessing Anti-flavivirus Immunity
An easy-to-use method for rapidly, accurately, and non-invasively assessing flavivirus immunity by measuring various antibody classes present in saliva. Background: Flaviviruses (including dengue virus) are the most common vector-borne human viral pathogens in the world. Nearly 40% of the world’s population are at risk of infection with dengue...
Published: 1/30/2026   |   Inventor(s): Adam Waickman, Stephen Thomas, Frank Middleton
Keywords(s): antibodies, antibody, infectious diseases, saliva, Technologies, viral immunology
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
Methods and Techniques to Classify Stages in the Gonotrophic Cycle of Mosquitoes from Images using Computer Vision Techniques
­Advantages: Enables rapid and accurate identification of mosquito gonotrophic stages, enhancing disease surveillance efforts effectively. Reduces the need for extensive entomological expertise, making mosquito monitoring more accessible and efficient. Facilitates integration with citizen-science platforms, empowering community involvement...
Published: 10/14/2025   |   Inventor(s): Sriram Chellappan, Farhat Azam, Ryan Carney, Sherzod Kariev
Keywords(s): Artificial Intelligence, Infectious Diseases, Predictive Analytics
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Data/AI > D/AI Imaging, Technology Classifications > Computer Science > Algorithms
Use of Dupilumab for Disseminated Fungal Infection (UCLA Case No. 2019-706)
BACKGROUND: Dupilumab, an immunomodulatory drug that blocks IL-4 signaling, is most commonly used to treat moderate-to-severe atopic dermatitis (a form of eczema) and asthma in both adults and adolescents. While fungal infections, such as coccidioidomycosis, can be potentially treated with immunomodulatory drugs, Dupilumab does not currently have...
Published: 7/17/2025   |   Inventor(s): Manish Butte, Maria Garcia-Lloret
Keywords(s): Infectious Diseases, Therapeutics & Vaccines
Category(s): Therapeutics, Therapeutics > Infectious Diseases
Clostridioides Difficile Vaccine targeting Binary Toxin CDT
­Advantages: Enhanced Vaccine Conservation: This technology ensures the conservation of critical vaccine components across diverse C. difficile strains, improving vaccine effectiveness. Immunogenic Potential: RBD2, a key discovery, exhibits exceptional immunogenicity, promising robust immune responses in vaccine recipients. Inhibition of CDT...
Published: 1/29/2026   |   Inventor(s): Xingmin Sun, Shaohui Wang
Keywords(s): Infectious Diseases, Vaccines
Category(s): Technology Classifications > Medical > Infectious Diseases
Flagellar Antigen Vaccine Candidate for Reducing Clostridioides difficile Colonization
­Advantages: Targets Early-Stage Pathogenesis Broad Antigen Conservation Across Clinical Strains Robust Mucosal and Systemic Immunogenicity Potential Alternative Therapy: Anti-FliCD serum demonstrates promise as an adjunct therapy for CDI, alongside vaccination. Summary: Clostridioides difficile (C. difficile) is an anaerobic, spore-forming,...
Published: 2/20/2026   |   Inventor(s): Xingmin Sun
Keywords(s): Infectious Diseases, Vaccines
Category(s): Technology Classifications > Medical > Infectious Diseases
Exploring Choroid Plexus Senescence as a Potential Link Between COVID-19 and Alzheimer's Disease
­Advantages: Advances viral neurology research by studying SARS-CoV-2's impact on the aging brain's choroid plexus. Identifies potential biomarkers for neurodegenerative diseases through cellular senescence and SASP factor analysis. Informs public health strategies regarding COVID-19-related neurological complications and preventive...
Published: 10/14/2025   |   Inventor(s): Eleni Markoutsa, Shyam Mohapatra, Subhra Mohapatra
Keywords(s): Infectious Diseases, Neurodegenerative Diseases, Therapeutics
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
Single Domain Antibodies Targeting the S2 Subunit of SARS-CoV-2 Spike Protein
Abstract: The COVID-19 pandemic is a worldwide public health crisis with over 100 million confirmed cases and 2.4 million deaths as of February 2021. COVID-19 is caused by a novel coronavirus called SARS-CoV-2. Almost all the neutralizing antibodies targeting SARS-CoV-2 that are in development recognize the receptor binding domain (RBD) on the spike...
Published: 5/14/2025   |   Inventor(s): Mitchell Ho, Zhijian Duan, Jesse Buffington
Keywords(s): : COVID-19, ANTIBODY, Camel Nanobody, CORONAVIRUS, HO, Infectious Diseases, Nanobodies, Pandemic, SARS-CoV-2, Shark Nanobody, therapeutic, Vaccine
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease
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