Search Results - metabolic

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Substituted Quinoline Analogs as Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors
Aldehyde dehydrogenase enzymes (ALDHs) have a broad spectrum of biological activities through the oxidation of both endogenous and exogenous aldehydes. Unbalanced biological activity of ALDHs has been associated with a variety of disease states such as alcoholic liver disease, Parkinson’s disease, obesity, and Cancer. Increased expression of ALDH1A1...
Published: 10/28/2024   |   Inventor(s): Anton Simeonov, David Maloney, Natalia Martinez, Adam Yasgar, Shyh-Ming Yang
Keywords(s): 1A1, 3D spheroid, ALDEFLUOR assay, Aldehyde, ALDH, ALDH1A1, cancer stem cells, combined treatment, DEHYDROGENASE, high-content imaging, high-throughput screening, Inhibitors, liver, METABOLIC, MOLECULE, OBESITY, OV-90, Parkinson, RESISTANT, SKOV-3, Small
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing
Pyruvate Kinase M2 Activators for the Treatment of Cancer
This technology describes a series of small-molecule activators of the pyruvate kinase M2 isoform (PK-M2). Pyruvate kinase (PK) is a critical metabolic enzyme that catalyzes the last step of the glycolytic pathway. It exists in several isoforms with different patterns of tissue expression. One isoform, PK-M2, is expressed in cells with a high rate...
Published: 11/5/2024   |   Inventor(s): Jian-kang Jiang, Matthew Boxer, Min Shen, Douglas Auld, Craig Thomas
Keywords(s): Activator, ACTIVATORS, CANCER, CBXXXX, CXXXXX, Dimer, IBXXXX, ISOFORM, IXXXXX, M2, METABOLIC, METABOLITE, PK, PKM2, PK-M2, Proliferation, PYRUVATE, pyruvate kinase, small molecule, Tetramer, tumor
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials
Novel Roles of a DNA Repair Protein, DNA-PKcs, in Obesity, Neurological Function, and Aging
The catalytic subunit of the DNA-dependent protein kinase complex (DNA-PKcs) has been shown to be important in DNA repair and VDJ recombination in lymphocytes. The inventors have discovered that DNA-PKcs also plays novel, important roles in energy regulation and neurological function. The inventors observed that mature DNA-PKcs-deficient mice (also...
Published: 10/28/2024   |   Inventor(s): Jay Chung
Keywords(s): Aging, ANXIETY, Cardiovascular, depression, DIABETES, DNA-Dependent, DNA-PKcs, Endurance, Energy, HEART, IB1XXX, IB3XXX, IB6XXX, IBXXXX, Inflammation, insulin, INSULIN-DEPENDENT, IXXXXX, LEARNING, MEMORY, METABOLIC, Metabolism, Mitochondria, Neurological, OBESITY, REGULATION, TYPE-2, Weight
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Cardiology, TherapeuticArea > Reproductive Health, TherapeuticArea > Immunology
Photosynthetic Production of 3-Hydroxybutyrate from Carbon Dioxide
The market interest in bioproduction of chemicals and polymers is steadily growing, driven by sustainability concerns and increashttp://azte.technologypublisher.com/files/sites/ncs-m12-182,-m14-208l,-m14-232l.pdfed environmental awareness. However, most production technologies rely on petroleum or food crops as feedstocks. In the coming decades, materials...
Published: 2/23/2023   |   Inventor(s): Bo Wang, Weiwen Zhang, Deirdre Meldrum, David Nielsen
Keywords(s): Algae, Microalgae, Cyanobacteria, Biofuels Production, Bioplastic and Biopolymers, Bio-Technology, Cell Metabolism, Chemicals, Environmental, Food, Grain, Nutrition, Metabolic, Photosynthesis, Solar Energy, Synthesis
Category(s): Alternative Energy/Biofuels/Bioplastics/Algae, Life Science (All LS Techs), Vectors/Constructs/Plasmids