Search Results - insulin

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Novel Human Insulin Cα-Peptide as an Antagonist for Islet and Brain Amyloidosis
Abstract: Over 32 million Americans are living with Diabetes and newly diagnosed cases of type 1 and type 2 diabetes is increasing. A defining feature of type 2 diabetes mellitus (T2DM) is the accumulation of islet amyloid polypeptide (IAPP) fibrils in pancreatic islets. Such accumulations form amyloid plaques, referred to as islet amyloidosis. Mounting...
Published: 4/8/2024   |   Inventor(s): Qing Rong Liu, Min Zhu, Pingbo Zhang, Josephine Egan, Luigi Ferrucci
Keywords(s): Alzheimer’s Disease, Amyloidosis, C-peptide, DIABETES, Egan, insulin, Islet Amyloid Polypeptide, Liu, National Institute on Aging, NIA
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Endocrinology
Natural product-based anti-cancer agents: aza-Englerin analogues
Abstract: Chemotherapy resistance in a wide array of cancers is often associated with enhanced glucose uptake and dysregulation of the insulin signaling pathway.  Therapeutics capable of inhibiting insulin signaling would be valuable as a stand-alone treatment and for sensitizing resistant tumors to standard chemotherapy regiments.  Researchers at NCI’s...
Published: 7/3/2024   |   Inventor(s): Willaim Chain, John Beutler, William Figg, Joe Ramos, Florian Suizmaier, Zhenwu Li, Daniel Fash, Ian Talisman, Cody Peer
Keywords(s): Ewing, Glycolytic, insulin, Resistance, Sarcoma
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology
Novel Roles of a DNA Repair Protein, DNA-PKcs, in Obesity, Neurological Function, and Aging
The catalytic subunit of the DNA-dependent protein kinase complex (DNA-PKcs) has been shown to be important in DNA repair and VDJ recombination in lymphocytes. The inventors have discovered that DNA-PKcs also plays novel, important roles in energy regulation and neurological function. The inventors observed that mature DNA-PKcs-deficient mice (also...
Published: 10/28/2024   |   Inventor(s): Jay Chung
Keywords(s): Aging, ANXIETY, Cardiovascular, depression, DIABETES, DNA-Dependent, DNA-PKcs, Endurance, Energy, HEART, IB1XXX, IB3XXX, IB6XXX, IBXXXX, Inflammation, insulin, INSULIN-DEPENDENT, IXXXXX, LEARNING, MEMORY, METABOLIC, Metabolism, Mitochondria, Neurological, OBESITY, REGULATION, TYPE-2, Weight
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Cardiology, TherapeuticArea > Reproductive Health, TherapeuticArea > Immunology