Search Results - cre

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Transgenic Hspa2-Cre Mice for Studying Spermatogenesis and Male Infertility
HSPA2 is a member of the HSP70 family of heat-shock proteins that serve as molecular chaperones. Hspa2-cre expression mimics the spermatogenic cell-specific expression of endogenous HSPA2 within the testis, being first observed in leptotene/zygotene spermatocytes. Expression of the transgene is also detected at restricted sites in the brain, as occurs...
Published: 10/28/2024   |   Inventor(s): Edward Eddy
Keywords(s): Cells, Cre, EXPRESSED, Gene, Generation, Hspa2, IDXXXX, IXXXXX, Line, Mouse, PROMOTER, Recombinase, REGULATION, Spermatogenesis, Spermatogenic, TRANSGENIC
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Research Materials, Application > Diagnostics
Mouse Model for Cerebral Cavernous Malformation, an Inherited Brain Disorder
Cerebral Cavernous Malformation (CCM) is a brain disease affecting up to 0.5% of the worldwide population. CCM is characterized by grossly dilated vessels prone to leaking and hemorrhage which result in severe headaches, seizures, and strokes. Inherited forms of the disease are due to mutations in one of three loci, CCM1, CCM2, and CCM3. Prior efforts...
Published: 10/28/2024   |   Inventor(s): YoSuke Mukoyama, Ulrich Siebenlist (Estate)
Keywords(s): brain, Cavernous Cerebral Malformation, CCM, CEREBRAL, Conditional, Cre, cre-lox, Floxed, Human, IDXXXX, Inherited, IXXXXX, Mouse, mouse model, RXXXXX
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials, Application > Diagnostics, Application > Therapeutics