Search Results - knock-out

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Novel mouse models of methylmalonic acidemia (MMA) : C57Bl6/Sv129 Mut-/- (full knock-out) and (C57Bl6/Sv129) FvBN Mut -/- (full knock-out)
Methylmalonic acidemia (MMA) is an autosomal recessive disorder caused by the deficiency of the mitochondrial enzyme methylmalonyl-CoA mutase (MUT). It is characterized by metabolic instability, multiorgan pathology, and poor prognosis for long-term survival. To study MMA caused by MUT deficiency, a series of murine models have been constructed using...
Published: 10/28/2024   |   Inventor(s): Randy Chandler, Charles Venditti
Keywords(s): -/-, :, Acidemia, C57Bl6/Sv129, FULL, FvBN, KNOCK-OUT, Methylmalonic, MMA, Models, Mouse, MUT, Mut-/-, Novel, VPXXXX, WIXXXX, XEXXXX
Category(s): TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Ophthalmology, TherapeuticArea > Dental, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Cardiology
Serotonin-Deficient Knock-out Mouse
Serotonin is an important modulator of many developmental, behavioral, and physiological processes, and it has been implicated in depression, anxiety, schizophrenia, obsessive compulsive disorders, and substance abuse. Serotonin’s pharmacology is extremely complex and it is mediated by seven of serotonin receptor subtypes and it is present in several...
Published: 10/28/2024   |   Inventor(s): Dennis Murphy
Keywords(s): AC6XXX, ACXXXX, AXXXXX, KNOCK-OUT, Mouse, MXXXXX, NC4XXX, NCXXXX, NXXXXX, Serotonin-Deficient, VEXXXX, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Neurology, Application > Diagnostics, Application > Research Materials
Tristetraprolin (TTP) Knockout Mice
National Institutes of Health researchers have developed knockout mice that do not express Tristetraprolin (TTP). TTP is an AU-rich element (ARE) binding protein and the prototype of a family of CCCH zinc finger proteins. AREs were identified as conserved sequences found in the 3’ untranslated region (3’ UTR) of a variety of transiently expressed...
Published: 10/28/2024   |   Inventor(s): Perry Blackshear
Keywords(s): AC5XXX, ACXXXX, AXXXXX, BAXXXX, CCXXXX, CXXXXX, IDXXXX, IXXXXX, KNOCK-OUT, Mouse, TTP
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Oncology, Application > Research Materials, Application > Therapeutics, Application > Diagnostics, ResearchProducts > Animal Models
A Gene Knockout Mouse Model to Study Lung Disease and a Lung Disease Drug Target
Our researchers have created a gene knockout mouse model that lacks the cytochrome c oxidase subunit IV-2 in order to study the gene’s effects on controlling asthma. Background & Unmeet Need: Asthma is an inflammatory disease of the airways that affects 155 million people of all ages worldwide. Cytochome c oxidase (CcO) is a multi-subunit...
Published: 12/17/2024   |   Inventor(s): Maik Huettemann, Lawrence Grossman, David Bassett
Keywords(s): Asthma, Disease, Drug Target, Gene, Knock-out, Lung, Mouse Model
Category(s): Animal models, Biological materials, Life Science, Research tools, Protein/peptides