Search Results - cre-lox

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Sirt1 Knockout (Sirt1tm1.1Cxd) Mouse Model for Oncology and Metabolism Studies
Sirt1 knockout: Sirt1, a protein deacetylase, is a tumor suppressor that promotes genome stability and regulates proteins involved in energy metabolism. Yeast Sir2, a nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase, has been implicated in chromatin silencing, longevity and genome stability. Mammals contain a family of related...
Published: 10/28/2024   |   Inventor(s): Chuxia Deng
Keywords(s): CCXXXX, cre-lox, Cre-loxP, CXXXXX, GCXXXX, GXXXXX, IDXXXX, IXXXXX, knockout mice, Mouse, Mouse animal model, SIRT1, Tm1.1Cxd
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials
Sirt3 Knockout (Sirt3tm1.1Cxd) Mouse Model for Cardiology and Metabolism Studies
Sirt3 knockout: Sirt3 is a mitochondrial-localized tumor suppressor that maintains mitochondrial integrity and metabolism during stress. Sirt3 is a mitochondrial protein that is a member of the Sirtuin family of NAD-dependent protein deacetylases. Sirt3(-/-) mice are phenotypically normal, but exhibit many proteins whose acetylation is increased....
Published: 10/28/2024   |   Inventor(s): Chuxia Deng
Keywords(s): cre-lox, Cre-loxP, IDXXXX, IXXXXX, Knock, Mouse, Sirt3, Tm1.1Cxd, Tm1Cxd
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics
Mouse Model for Cerebral Cavernous Malformation, an Inherited Brain Disorder
Cerebral Cavernous Malformation (CCM) is a brain disease affecting up to 0.5% of the worldwide population. CCM is characterized by grossly dilated vessels prone to leaking and hemorrhage which result in severe headaches, seizures, and strokes. Inherited forms of the disease are due to mutations in one of three loci, CCM1, CCM2, and CCM3. Prior efforts...
Published: 10/28/2024   |   Inventor(s): YoSuke Mukoyama, Ulrich Siebenlist (Estate)
Keywords(s): brain, Cavernous Cerebral Malformation, CCM, CEREBRAL, Conditional, Cre, cre-lox, Floxed, Human, IDXXXX, Inherited, IXXXXX, Mouse, mouse model, RXXXXX
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials, Application > Diagnostics, Application > Therapeutics