Search Results - maurice+swanson

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Flumazenil for Treatment of CNS Symptoms in Myotonic Dystrophy
Application A class of drugs that inhibit molecules responsible for the severe nervous system complications associated with myotonic dystrophy. Key Benefits Potentially the first medication for treating the severe nervous system symptoms associated with myotonic dystrophy by targeting GABRG2. Transdermal and oral administration. May drive the...
Published: 10/28/2024   |   Inventor(s): Gary Bassell, Andrew Jenkins, David Rye, Eric Wang, Maurice Swanson, Lyndon Lien
Keywords(s): Neuroscience/Pain
Category(s): TechPub Algolia > Therapeutics
Monoclonal Antibodies against Heterogeneous Nuclear Ribonuclear Proteins (hnRNP) m3/4 & m1-4
Recognize hnRNP-M3 As WellHeterogeneous nuclear ribonucleoproteins (hnRNPs), which directly bind to nascent RNA polymerase II transcripts, play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. These "M proteins" are pre-mRNA-binding proteins in vivo, and they bind to poly(G) and poly(U) RNA homopolymers...
Published: 7/12/2022   |   Inventor(s): Maurice Swanson
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Others
Monoclonal Antibody against CUGBP2/ETR-3 Proteins
Recognizes Both Human and Mouse CUGBP2/ETR-3 Proteins but Does Not Bind to Other CELF Family MembersCUGBP2/ETR-3 is a member of the CELF family of pre-mRNA alternative splicing factors which play an important role in the appearance of specific protein isoforms during postnatal development. The CELF family has also been implicated in the neuromuscular...
Published: 7/12/2022   |   Inventor(s): Maurice Swanson
Keywords(s): Antibody, COX2, CUGBP2, Monoclonals, Myotonic Dystrophy, RNA Splicing, RNA Turnover
Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Biological Materials, Technology Classifications > Research Tools > Others
Monoclonal Antibodies against Yeast RNA- and DNA-Binding Proteins (e.g. PUB1, PAB1, NAB2p)
PUB1, targeting protein that aids in RNA translation and exportPolyuridylate-binding protein (PUB1) is a member of the ribonuclear protein consensus sequence family of RNA-binding proteins and is structurally related to the human heterologous nuclear RNA-binding proteins (hnRNP) M proteins. PUB1 is localized in a non-uniform pattern throughout both...
Published: 7/12/2022   |   Inventor(s): Maurice Swanson
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Biological Materials, Technology Classifications > Research Tools > Others
Dmpk CTG480 Knockin Myoblasts as a Cell Model for Myotonic Dystrophy Type 1
Myoblasts Isolated from a Myotonic Dystrophy Type 1 Mouse Model Serve as a Platform for Drug Development and ResearchThese Dmpk CTG480 knockin mouse myoblasts are isolated from Dmpk CTG480 knockin mice for use as a cell model for myotonic dystrophy type 1. Myotonic dystrophy type 1 (DM1) is an inherited, multi-system disorder, affecting 1 in 8500 individuals...
Published: 6/27/2021   |   Inventor(s): Maurice Swanson, Curtis Nutter
Keywords(s): DM1, microsatellites, Mouse Model, Myotonic Dystrophy
Category(s): Technology Classifications > Research Tools > Biological Materials
Dmpk CTG480 Knock-in Mouse Model for Myotonic Dystrophy Type 1
Myotonic Dystrophy Type 1 Mouse Model as a Tool for Drug Development and ResearchMyotonic dystrophy type 1 (DM1) is an inherited, multi-system disorder, affecting 1 in 8,500 individuals worldwide. However, no effective therapies are currently available for this disease. Clinical symptoms may vary from almost asymptomatic to progressive skeletal muscle...
Published: 7/18/2023   |   Inventor(s): Ruan Oliveira, Maurice Swanson
Keywords(s): DM1, microsatellites, Mouse Model, Myotonic Dystrophy
Category(s): Technology Classifications > Research Tools > Biological Materials