Search Results - gbm

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Compounds and Methods for Treating Cancer by Destroying Cancer Stem Cells (UCLA Case No. 2021-286)
Researchers from UCLA’s Department of Chemistry and Biochemistry and the Department of Radiation Oncology have synthesized a set of compounds for the eradication of cancer stem cells. These compounds are predicted to cross the blood brain barrier and show promise as effective interventions for glioblastoma in both in vitro and in vivo assays. BACKGROUND:...
Published: 7/11/2024   |   Inventor(s): Michael Jung, Frank Pajonk
Keywords(s): blood-brain barrier, Brain, Cancer, Cancer stem cells, drug screening, GBM, Glioblastoma, Glioma, new chemical entity
Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology, Therapeutics > Stem Cells And Regenerative Medicine
Targeted Epigenetic Editing as Novel Therapy for Malignant Glioma (UCLA Case No. 2023-047)
UCLA Researchers in the Department of Neurology/Neuro-Oncology and the David Geffen School of Medicine have developed methods for the Cas9-CRISPR mediated epigenetic targeting of malignant glioma, and which results in enhanced chemosensitivity to standard chemotherapeutic agents. BACKGROUND: Malignant gliomas are aggressive brain tumors originating...
Published: 1/17/2024   |   Inventor(s): Serendipity Zapanta Rinonos, Albert Lai
Keywords(s): Brain, Cancer, Cancer stem cells, Chemotherapy, Combination therapy, CRISPR, CRISPR-Cas9, Epigenetics, GBM, Glioma
Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology
A Preclinical Orthotopic Model for Glioblastoma Multiforme that Represents Key Pathways Aberrant in Human Brain Cancer
Abstract: Current therapies for glioblastoma multiforme (GBM), the highest grade malignant brain tumor, are mostly ineffective, and better preclinical model systems are needed to increase the successful translation of drug discovery efforts into the clinic. Scientists at the National Cancer Institute (NCI) have developed and characterized an orthotopic...
Published: 4/8/2024   |   Inventor(s): Zoe Ohler, Rajaa El Meskini, Anthony Lacovelli, Alan Kulaga, Michelle Gumprecht, Terry Van Dyke
Keywords(s): Brain Cancer, GBM, GEM, Genetically Engineered Mouse, Meskini, mouse model, Multiforme, Ohler Weaver, Orthotopic Glioblastoma
Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Oncology, TherapeuticArea > Neurology
Glioblastoma Stem Cell Regulators with Therapeutic Potential
Targets Crucial Cancer Stem Cell Factors to Inhibit Glioblastoma Growth This combination of cancer master regulators enables targeting glioblastoma (GBM) stem cells to inhibit their growth. According to the National Brain Tumor Society, only 5.5 percent of patients suffering from GBM survive five or more years after diagnosis, due to rapid cell growth...
Published: 6/27/2021   |   Inventor(s): David Tran, Son Le
Keywords(s): cancer drug targets, GBM, GBM stem cells, Glioblastoma, master regulators, stemness
Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Human Health Care > Therapeutics