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Mouse Model for Cerebral Cavernous Malformation, an Inherited Brain Disorder
Cerebral Cavernous Malformation (CCM) is a brain disease affecting up to 0.5% of the worldwide population. CCM is characterized by grossly dilated vessels prone to leaking and hemorrhage which result in severe headaches, seizures, and strokes. Inherited forms of the disease are due to mutations in one of three loci, CCM1, CCM2, and CCM3. Prior efforts...
Published: 10/28/2024   |   Inventor(s): YoSuke Mukoyama, Ulrich Siebenlist (Estate)
Keywords(s): brain, Cavernous Cerebral Malformation, CCM, CEREBRAL, Conditional, Cre, cre-lox, Floxed, Human, IDXXXX, Inherited, IXXXXX, Mouse, mouse model, RXXXXX
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials, Application > Diagnostics, Application > Therapeutics