Search Results - brain

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Device and Method for Recording-Guided Neuromodulation via the Olfactory Cleft (Case No. 2026-077)

Summary: UCLA researchers in the Department of Neurology have developed a minimally invasive, recording-guided closed-loop neuromodulation device enabling transnasal access to olfactory-cleft pathways for targeted modulation of deep limbic brain circuits. Background: The olfactory bulb provides direct anatomical and functional pathways to the limbic...

Published: 6/3/2026 | Updated: 5/28/2026 | Inventor(s): Kevin Bickart, Mahmoud Omidbeigi

Keywords(s): Brain, Deep Brain Stimulation, Deep Brain Stimulation Current Mirror Output Impedance, device stability, Electrical Brain Stimulation, Electrical stimulation, minimally invasive device, neural stimulation, Neuromodulation, Neurostimulation, noninvasive, non-invasive, non-invasive monitoring, Transcutaneous Electrical Nerve Stimulation

Category(s): Software & Algorithms > Bioinformatics, Therapeutics > CNS and Neurology, Software & Algorithms > Digital Health, Electrical, Life Science Research Tools, Medical Devices, Medical Devices > Monitoring And Recording Systems, Medical Devices > Neural Stimulation

Broad-Band Frequency Repetitive Transcranial Magnetic Stimulation for the Treatment of Neuropsychiatric Disorders (Case No. 2025-99J)

Summary: Researchers in UCLA's Semel Institute and Department of Psychiatry have developed an innovative approach to treating depression by optimizing repetitive Transcranial Magnetic Stimulation (rTMS), improving its effectiveness for the treatment of Major Depressive Disorder (MDD) and possibly diseases of the mind and brain. Background: Depression...

Published: 10/16/2025 | Updated: 10/9/2025 | Inventor(s): Andrew Leuchter, Juliana Corlier, Thomas Valles

Keywords(s): Bioelectromagnetics, Brain, Deep Brain Stimulation, Electrical Brain Stimulation, energy-efficient, frequency modulation, Magnetic Field, Medical Device, medication efficacy, neural information, neural network, neural networks, neural signals, neural stimulation, neurobehavioral impairment, Neurocognitive, neurological disorders, Neuromodulation, Neuron, neurons, neuroscience, Neurostimulation, pulsed load modulation, therapy, treatment efficacy

Category(s): Medical Devices, Medical Devices > Neural Stimulation, Life Science Research Tools, Therapeutics > CNS and Neurology, Therapeutics

Chip-scale Photonic Processing Neuroprosthetic Detector

A novel technology for optimizing visual prosthetics for individuals with foveal blindness. Background: The International Agency for the Prevention of Blindness expects 196 million people to suffer from macular degeneration worldwide in 2020. Millions more will suffer from traumatic ocular injury or glaucoma or other foveal defects. The result will...

Published: 3/25/2026 | Updated: 5/13/2025 | Inventor(s): Stephen Macknik, Susana Martinez-Conde, Edward White, Satyavolu Papa Rao, Spyridon Galis, John Carter, Olivya Caballero

Keywords(s): brain, cortex, multi-color spatiochromatic encoding, neural recording, OBServ, Technologies

Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Healthcare, Technology Classifications > Medical Devices, Campus > NY CREATES

Microbial Metabolites for Promoting Brain Health (UCLA Case No. 2024-196)

UCLA researchers in the Department of Integrative Biology and Physiology have developed a maternal supplementation with microbiome-dependent metabolites to promote growth and neurobehavioral health in children impacted by maternal protein undernutrition. BACKGROUND: Protein undernutrition poses a significant risk of childhood stunting, accompanying...

Published: 7/17/2025 | Updated: 12/12/2024 | Inventor(s): Elaine Hsiao

Keywords(s): Brain, brain health, growth defects, malnutrition, maternal supplementation, microbial metabolites, microbiome, neurobehavioral impairment, neurodevelopment, nutrition, protein undernutrition, stunting

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health

Compounds and Methods for Treating Cancer by Destroying Cancer Stem Cells (UCLA Case No. 2021-286)

Researchers from UCLA’s Department of Chemistry and Biochemistry and the Department of Radiation Oncology have synthesized a set of compounds for the eradication of cancer stem cells. These compounds are predicted to cross the blood brain barrier and show promise as effective interventions for glioblastoma in both in vitro and in vivo assays. BACKGROUND:...

Published: 8/28/2025 | Updated: 7/11/2024 | Inventor(s): Michael Jung, Frank Pajonk

Keywords(s): blood-brain barrier, Brain, Cancer, Cancer stem cells, drug screening, GBM, Glioblastoma, Glioma, new chemical entity

Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology, Therapeutics > Stem Cells And Regenerative Medicine

HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS

HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS Researchers at UCSF and UC Berkeley have developed a recombinant adeno-associated virus (rAAV) with an altered capsid protein, where the rAAV exhibits greater ability to infect a central nervous system cell compared to wild-type AAVs. The central nervous system (CNS) comprises a multitude...

Published: 10/26/2023 | Updated: 10/26/2023 | Inventor(s): Tomasz Nowakowski, Galina Popava (Schmunk), David Schaffer, Danqing Zhu

Keywords(s): Adeno-associated Virus, Brain, Neuron

Category(s): Technology Classifications > Biology

COMPOSITIONS AND METHODS RELATED TO TRANSCOBALAMIN RECEPTOR AUTOANTIBODIES

COMPOSITIONS AND METHODS RELATED TO TRANSCOBALAMIN RECEPTOR AUTOANTIBODIES Researchers at CZ Biohub SF and UCSF have developed methods and kits to detect autoantibodies targeting the transcobalamin receptor CD320, which is associated with neurological symptoms in certain patients, as well as methods to treat patients with this condition. Vitamin...

Published: 10/26/2023 | Updated: 10/26/2023 | Inventor(s): John Pluvinage, Michael Wilson, Joseph DeRisi, Samuel Pleasure

Keywords(s): Autoantibody, Brain, Vitamin B12

Category(s): Technology Classifications > Biology

Targeted Epigenetic Editing as Novel Therapy for Malignant Glioma (UCLA Case No. 2023-047)

UCLA Researchers in the Department of Neurology/Neuro-Oncology and the David Geffen School of Medicine have developed methods for the Cas9-CRISPR mediated epigenetic targeting of malignant glioma, and which results in enhanced chemosensitivity to standard chemotherapeutic agents. BACKGROUND: Malignant gliomas are aggressive brain tumors originating...

Published: 10/7/2025 | Updated: 9/20/2023 | Inventor(s): Serendipity Rinonos, Albert Lai

Keywords(s): Brain, Cancer, Cancer stem cells, Chemotherapy, Combination therapy, CRISPR, CRISPR-Cas9, Epigenetics, GBM, Glioma

Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology

Tamperless Tensor Elastography Imaging

Summary: The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seeks research co-development partners and/or licensees for the development of tamper-less tensor elastography imaging in assessing disease (e.g., cancer), normal and abnormal developmental processes, degeneration and trauma in the brain and other soft...

Published: 4/23/2026 | Updated: 8/2/2023 | Inventor(s): Peter Basser, Magdoom Mohamed Kulam Najmudeen

Keywords(s): Alzheimer’s Disease, Anisotropy, Basse, brain, CANCER, Elasticity Tensor, Elastography, Eunice Kennedy Shriver National Institute of Child Health an, Magnetic Resonance Imaging, MRI, Najmudeen, NICHD, TBI, TRAUMA, Traumatic Brain Injury

Category(s): TherapeuticArea > Neurology, Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Use of Neurotrophic Factor-alpha1/Carboxypeptidase E (CPE) to Treat Alzheimer Disease

Summary: The NICHD is seeking licensees for development of Carboxypeptidase E (CPE) as a therapy for MCI or AD. Description of Technology: There is no known cure for Alzheimer’s disease, a brain disorder that severely affects memory, thinking, learning, and organizing skills. It eventually decreases a person’s ability to carry out simple,...

Published: 4/24/2026 | Updated: 8/2/2023 | Inventor(s): Yoke Peng Loh, Yong Cheng

Keywords(s): “Cognitive impairment”, Ad, Alzheimer’s Disease, BNDF, brain, Brain-Derived Neurotrophic Factor, Carboxypeptidase E, CPE, Hippocampus, LOH, MCI, MEMORY, Mild Cognitive Impairment, NEURODEGENERATION, NEUROTROPHIC

Category(s): TherapeuticArea > Neurology, Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration

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