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Synthetic lipopeptide inhibitors of RAS oncoproteins

Abstract: It is well known that overactive Ras signaling is linked to many forms of cancer, and despite intensive efforts worldwide to develop effective inhibitors of Ras, to date there is no anti-Ras inhibitor in clinical use. Researchers at the NCI’s Cancer and Inflammation Program, in collaboration with scientists at Vanderbilt University and the...

Published: 6/11/2024 | Inventor(s): Nadya Tarasova, Sergey Tarasov, Vadim Gaponenko, Joseph Kates, Michael Dean, Alla Ivanova

Keywords(s): COLON, LUNG, MULTIPLE MYELOMA, Pancreatic Cancer, RAS, THYROID CANCER

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

METHODS AND SYSTEM FOR SPECTRAL IMAGING OF DENSITY, ANISTROPY, AND ORIENTATION

METHODS AND SYSTEM FOR SPECTRAL IMAGING OF DENSITY, ANISTROPY, AND ORIENTATION Researchers at the Chan Zuckerberg Biohub have developed an imaging module and computational algorithms for high-speed spectral quantitative imaging of density and anisotropy in fluorescence and label-free contrasts. Microscopy is central to biological research and...

Published: 3/17/2023 | Inventor(s): Shalin Mehta, Ivan Ivanov, Li-Hao Yeh

Keywords(s): Anisotropy, Biomolecules, Density, Microscopy, Optical Imaging, Polarization

Category(s): Technology Classifications > Engineering

METHOD AND SYSTEM FOR QUANTITATIVE THREE-DIMENSIONAL MEASUREMENT OF DENSITY, ANISOTROPY, AND ORIENTATION WITHOUT LABEL

METHOD AND SYSTEM FOR QUANTITATIVE THREE-DIMENSIONAL MEASUREMENT OF DENSITY, ANISOTROPY, AND ORIENTATION WITHOUT LABEL Researchers at the Chan Zuckerberg Biohub have developed a label-free computational imaging method for measuring optical properties of a specimen. Biological architecture is intrinsically tensorial. The permittivity tensor (PT)...

Published: 3/17/2023 | Inventor(s): Shalin Mehta, Ivan Ivanov, Li-Hao Yeh

Keywords(s): Anisotropy, Biomolecules, Density, Microscopy, Optical Imaging, Polarization

Category(s): Technology Classifications > Engineering