Search Results - head

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Improved PE-based Targeted Toxins: A Therapeutic with Increased Effectiveness
Abstract: Targeted toxins (e.g., immunotoxins) are therapeutics that have at least two important components: (1) a toxin domain that is capable of killing cells and (2) a targeting domain that is capable of selectively localizing the toxic domain to only those cells which should be killed. By selecting a targeting domain that binds only to certain diseased...
Published: 5/21/2024   |   Inventor(s): Ira Pastan, Richard Beers, Masanori Onda
Keywords(s): Breast, HEAD, Hematological cancer, Immunotoxin, Ligand-targeted toxin, LUNG, NECK, OVARIAN, Toxin domain
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Cardiology
Prevention of Head and Neck Cancer Using Rapamycin and Its Analogs
It is frequently observed in head and neck squamous cell carcinoma (HNSCC), a cancer occurring mostly in the mouth, that the Akt/mTOR pathway is abnormally activated. Therefore, inhibiting this signaling pathway may help in treating this disease. Rapamycin and its analogs are known to inhibit the activity of mTOR so in principle they could serve as...
Published: 10/28/2024   |   Inventor(s): Panomwat Amornphimoltham, Rakefet Czerninski, Vyomesh Patel, Alfredo Molinolo, J Silvio Gutkind
Keywords(s): (4)r syndrome, C syndrome, Carcinoma, CBXXXX, CHEMOPREVENTIVE, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, Cowden's disease, Cowden's syndrome, CXXXXX, G syndrome, HEAD, Hypertelorism with esophageal abnormality and hypospadias, Listed LPM Campbell as of 4/15/2015, MTOR-inhibitors, N syndrome, NECK, Patent Category - Biotechnology, Patent Category - Chemistry, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, R(6) syndrome, R(7) syndrome, Rapamycin, SQUAMOUS, Squamous cell carcinoma, Syndrome X, W syndrome, W syndrome; Syndrome W
Category(s): Application > Therapeutics, TherapeuticArea > Oncology
System for Correction of MRI Head Motion
Motion artifacts continue to be a significant problem in MRI of human brain. Prospective motion correction based on external tracking systems has been proposed to ameliorate this issue. However, the calibration of these systems is very complicated and time consuming, as it requires a camera system calibration as well as a calibration between camera...
Published: 4/8/2024   |   Inventor(s): Lei Qin, Jozef (Jeff) Duyn
Keywords(s): AA2XXX, AA3AXX, AA3B1X, AA3B6X, AA3BXX, AA3XXX, AA4BXX, AA4XXX, AAXXXX, AXXXXX, CAMERA, HEAD, MOVEMENT, MRI
Category(s): Collaboration Sought > Collaboration