Search Results - ovarian

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Improved PE-based Targeted Toxins: A Therapeutic with Increased Effectiveness
Abstract: Targeted toxins (e.g., immunotoxins) are therapeutics that have at least two important components: (1) a toxin domain that is capable of killing cells and (2) a targeting domain that is capable of selectively localizing the toxic domain to only those cells which should be killed. By selecting a targeting domain that binds only to certain diseased...
Published: 5/21/2024   |   Inventor(s): Ira Pastan, Richard Beers, Masanori Onda
Keywords(s): Breast, HEAD, Hematological cancer, Immunotoxin, Ligand-targeted toxin, LUNG, NECK, OVARIAN, Toxin domain
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Cardiology
Reduced Virulence Crimean-Congo Hemorrhagic Fever Virus for Vaccine Development
This invention relates to a genetically modified hemorrhagic fever virus that can be used as an effective live vaccine agent. Hemorrhagic fever evades the human immune response using the viral ovarian tumor domain (vOTU) protease, which inhibits critical host-immunity functions. The present genetically modified virus has a vOTU protease with decreased...
Published: 10/28/2024   |   Inventor(s): Scott Pegan, MIchelle Deaton, Stuart Nichol, Eric Bergeron
Keywords(s): ABLATION, Activities, Crimean-Congo, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DeiSGylating, Deubiqutinating, Domain, DXXXXX, FEVER, HEMORRHAGIC, OVARIAN, Protease's, SIMULTANEOUS, tumor, Vaccine, virus
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Research Materials
Intracavitary Radiation Applicator
Project ID D2005-05 BackgroundHigh Dose Rate (HDR) brachytherapy is an internal radiation treatment that distinguishes itself from external beam radiotherapy by passing a source of radiation through thin tubes placed either within cancerous tissue (interstitial HDR), or inside a body cavity in close vicinity of tumors. These approaches allow treatment...
Published: 8/3/2022   |   Inventor(s): E. Parsai, John Feldmeier
Keywords(s): Brachytherapy, Cervical, Oncology, Ovarian, Pelvic tumors, Vaginal endometria cancer
Category(s): Radiation Oncology, Medical Device