Search Results - james+yang

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2023-087 Thiophene Configurable Amorphous Small Molecular Hole Transporting Material for Efficient and Stable Perovskite Solar Cell
Summary: UCLA researchers in the Department of Materials Science and Engineering have invented a series of hole transporting materials that have enabled among the highest recorded power conversion efficiencies for perovskite solar cells while maintaining high device stability and low cost. Background: Perovskite solar cells (PSCs) are an emerging...
Published: 6/25/2024   |   Inventor(s): Yang Yang, Dong Meng
Keywords(s): buffer layer, charge collection, charge collection efficiency, charge extraction, charge-transfer, device architectures, device stability, hole transporting material, hydrophobicity, interfacial layer, ion-migration, n-i-p device, perovskite, Perovskite Lead(II) Iodide, perovskite solar cell, photostability, p-i-n device, power conversion efficiency, radiosurgery, Silicon Working Electrode Perovskite (Structure), spinal surgery, thermal stability
Category(s): Chemical, Electrical, Energy & Environment > Energy Generation > Solar, Materials, Materials > Functional Materials, Electrical > Electronics & Semiconductors
T Cell Receptors Targeting the KRAS G13D Mutation in the Context of HLA-A11:01 for Research Use
Summary: The National Cancer Institute (NCI) has identified HLA-A11:01-restricted T Cell Receptors (TCRs) targeting the KRAS G13D mutation. The NCI seeks licensees for the use of these TCRs in research. Description of Technology: Tumor-specific mutated proteins can create immunogenic, mutation-containing “neoepitopes” which are attractive...
Published: 4/8/2024   |   Inventor(s): Catherine Ade, Zhiya Yu, Matthew Sporn, James Yang, Kenichi Hanada
Keywords(s):  
Category(s): TherapeuticArea, Application, Application > Research Materials, Collaboration Sought > Licensing
T cell Receptors Which Recognize Mutated EGFR
Abstract: Epidermal growth factor receptor (EGFR) is a transmembrane protein involved in cell growth and proliferation. Mutations in this protein can lead to overexpression, causing several types of cancer; notably, non-small cell lung cancer (NSCLC). For example, mutations in EGFR are found in up to 50% of NSCLC patients and the E746-A750 deletion...
Published: 4/8/2024   |   Inventor(s): Kenichi Hanada, Chihao Zhao, Anna Pasetto, James Yang
Keywords(s): EGFR mutation, Epidermal Growth Factor Receptor, Hanada, Immunotherapy, T Cell Receptor, TCR
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Collaboration
Extremely Rapid Method to Isolate Neoantigen Reactive T Cell Receptors (TCRs)
Abstract: Adoptive cell transfer (ACT) uses tumor infiltrating lymphocytes (TILs) that recognize unique antigens expressed by cancer cells (“neoantigens”). Neoantigen specific TIL administration in patients has resulted in long term regression of certain metastatic cancers. However, one of the challenges of ACT and engineered T cell receptor (TCR) therapies...
Published: 4/8/2024   |   Inventor(s): Sri Krishna, Paul Robbins, Rami Yoseph, James Yang, Kenichi Hanada, Frank Lowery, Steven Rosenberg
Keywords(s): act, Adoptive Cell Transfer, Immunotherapy, Neoantigen, Rosenberg, T Cell Receptor, TCR, TIL, tumor, Tumor Infiltrating Lymphocyte
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
Novel Murine T-Cell Receptors for Treating Metastatic Thyroid Cancer
Abstract: The occurrence of thyroid cancer has been increasing in the United States. For some patients, with particularly advanced and metastatic cancer, current treatments such as thyroidectomy and adjuvant radioactive iodine therapy can lead to poor outcomes. Hence, there is a need for new thyroid cancer treatments. Researchers at the NCI have developed...
Published: 4/8/2024   |   Inventor(s): Kenichi Hanada, Qiong Wang, James Yang, Zhiya Yu
Keywords(s): act, adoptive cell therapy, Human Thyroglobulin, Immunotherapy, METASTATIC, T-cell Receptors, TCR, TCRs, Tg, THYROID CANCER, Yang
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration
T Cell Receptors Targeting BRAF V600E Mutation for Cancer Immunotherapy
Abstract: BRAF is an oncogene that encodinges a serine-threonine kinase (B-Raf kinase) important in regulating cell growth and differentiation. Spontaneous mutations in the BRAF gene allow cells to continuously divide, leading to the development of cancer. A substitution of glutamic acid for valine at amino acid number 600 (designated V600E) accounts...
Published: 8/14/2024   |   Inventor(s): Zhiya Yu, Catherine Ade, Matthew Sporn, James Yang, Kenichi Hanada
Keywords(s): BRAF, B-Raf kinase, B-Raf Proto-Oncogene, HLA-A*0301 restriction, Immunotherapy, Rosenberg, serine-threonine kinase, T Cell Receptor, T cell therapy, TCR, V600E mutation, Yang, Yu
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Novel Immunotherapy for Cancer Treatment: Chimeric Antigen Receptors Targeting CD70 Antigen
Abstract: Scientists at the NCI's Surgery Branch have developed anti-CD70 chimeric antigen receptors (CARs) to treat cancers. CD70 is an antigen that is expressed on a variety of human cancers such as renal cell carcinoma, glioblastoma, non-Hodgkin's lymphoma, and chronic lymphocytic leukemia. The anti-CD70 CARs are hybrid proteins consisting of a receptor...
Published: 4/8/2024   |   Inventor(s): Qiong Wang, Zhiya Yu, James Yang
Keywords(s): CARS, CD70, chimeric antigen receptor, T-cell reprogramming
Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing
Novel Cancer Immunotherapy: A T Cell Receptor That Specifically Recognizes Common KRAS Mutations
Abstract: Several malignancies associated with a poor prognosis such as lung, pancreatic and colorectal cancers frequently harbor constitutively active KRAS mutants, which play a pivotal role in oncogenesis.  Currently, there are no potentially curative treatments against most mutant KRAS harboring cancers once they become metastatic and unresectable. ...
Published: 4/8/2024   |   Inventor(s): Qiong Wang, James Yang, Zhiya Yu
Keywords(s): Colorectal, Immunotherapy, KRAS, LUNG, oncogenesis, PANCREAS, PROSTATE, T cell, TCR
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics
New Small Molecules for Stable and Efficient Organic Photovoltaics (UCLA Case No. 2023-086)
Summary: UCLA researchers in the Department of Materials Science and Engineering have developed a novel molecule for organic photovoltaics, photodetectors, organic field effect transistors, and other relevant applications. Background: Among all competing photovoltaic technologies, the organic photovoltaics (OPVs) market is likely to grow the fastest,...
Published: 12/8/2023   |   Inventor(s): Yang Yang, Dong Meng
Keywords(s): Concentrated Solar Power, Concentrated Solar Power Chemical Engineering, energy conversion, energy conversion applications, energy recycle, interfacial layer, Methods Of Detecting Extrasolar Planets, multi-junction tandem devices, near-infrared, organic field effect transistors, organic photo detector, organic photovoltaics, Organic Solar Cell, perovskite devices, perovskite solar cell, Polymer Solar Cell, rganic light-emitting diodes, Solar Cell, Solar Cell Metamaterial, Solar Cell Molecular Electronics, Solar Energy, Thin Film Solar Cell, transparent OPVs, ultra-narrow bandgap
Category(s): Electrical, Electrical > Electronics & Semiconductors, Materials > Functional Materials, Energy & Environment > Energy Generation > Solar
2022-216 Electrode for Rechargeable Batteries that Resists Dendrite Growth
Summary: UCLA researchers in the Department of Material Science and Engineering have developed electrodes for rechargeable batteries which resist dendrite growth. Background: Rechargeable batteries have attracted attention due to their wide array of applications and environmental benefits. Rechargeable metal-ion batteries, such as lithium-ion batteries,...
Published: 7/19/2023   |   Inventor(s): Yang Yang, Xiaochun Li
Keywords(s): Alloy, Dendrite, Electrode, Lithium Battery, Lithium-Ion Battery, Nanoelectronics, Nanoparticle, Rechargeable Battery, Rechargeable Battery Thermal Conductivity
Category(s): Materials > Semiconducting Materials, Energy & Environment > Energy Efficiency, Energy & Environment > Energy Storage, Electrical > Electronics & Semiconductors, Energy & Environment > Energy Storage > Batteries
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