Search Results - tissue

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Novel Fixative for Improved Biomolecule Quality from Paraffin-Embedded Tissue
Abstract: Tissues samples collected during medical procedures, such as biopsies, are used to diagnose a wide variety of diseases. Before diagnosis, patient samples are typically processed by fixation and paraffin embedding. This fixation/embedding process is used to preserve tissue morphology and histology for subsequent evaluation. Unfortunately, most...
Published: 4/8/2024   |   Inventor(s): Stephen Hewitt, Candice Perry, Joon-Yong Chung, Robert Star
Keywords(s): CULTURE, fixative, Histology, PARAFFIN, PATHOLOGY, Tissue
Category(s): Collaboration Sought > Licensing, Application > Medical Devices, TherapeuticArea > Oncology, Application > Non-Medical Devices
Composite Gels and Methods of their Use in Tissue Repair, Drug Delivery, and as Implants
Abstract: Gel materials, particularly hydrogels, typically lose their mechanical strength and stiffness as they swell. This property  limits their use in both biological (e.g., cartilage and ECM repair) and non-biological (e.g., sealant) applications. Innovative materials in both medical and non-medical application areas are sorely needed. Recent innovations...
Published: 4/8/2024   |   Inventor(s): Ferenc Horkay, Peter Basser
Keywords(s): Basser, Cartilage, Composite, Drug Delivery, Gel, Horkay, Hydrogels, IMPLANTS, MATRIX, polymer, sealants, Tissue, Tissue Repair
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Non-Medical Devices, Application > Medical Devices, Collaboration Sought > Materials Available, TherapeuticArea > Dermatology
A Specialized Tissue Collection Device for the Preservation and Transportation of Needle Biopsies
Abstract: The ability to hold and transport tissue, especially needle biopsies in a pre-defined and controlled environment is critical for the preservation of biopsy samples in downstream analytic applications. Currently, tissue specimens are placed in open containers with variable, poorly controlled solutions applied to them, often in less than sterile...
Published: 4/8/2024   |   Inventor(s): Stephen Hewitt, Robert Star, Hiroshi Kijoma, Jeffrey Hanson, Armando Filie, Russell Bandle
Keywords(s): COLLECTION, DEVICE, FIXATION, Hewitt, KIDNEY, liver, LUNG, Needle Biopsy, PANCREAS, PRESERVATION, STERILE, Storage, Tissue, Transportation
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Medical Devices, Collaboration Sought > Collaboration, Application > Non-Medical Devices
Enhanced Tissue Clearing Solution, Clearing-Enhanced 3D (Ce3D), Compatible with Advanced Fluorescence Microscopy Imaging
NIH immunologists have created a solution, Clearing-enhanced 3D (Ce3D), that can be used to make entire organs extremely transparent (top right panel). This allows the tissue to be imaged using advanced fluorescence microscopy techniques (bottom panel). Unlike current tissue clearing solutions, the Ce3D tissue clearing solution is robustly compatible...
Published: 10/28/2024   |   Inventor(s): Michael Gerner, Weizhe Li, Ronald Germain
Keywords(s): 3D, AA3AXX, Ce3D:, Cellular, Clearing, Epitope, Fluorescence, histo-cytometry, IMAGING, imaging agent, Method, MICROSCOPY, REPORTER, Tissue
Category(s): Collaboration Sought > Collaboration
Methods for Treating or Ameliorating Fibrosis by Inhibiting the Interaction between IL-21 Receptor (IL-21R) and IL-21
This invention includes methods for treating or ameliorating fibrosis by inhibiting the interaction between IL-21 Receptor (IL-21R) and IL-21 using either anti-IL-21R monoclonal antibodies (or binding fragments of anti-IL-21R mAbs), anti-IL-21 monoclonal antibodies (or binding fragments of anti-IL-21 mAbs) or soluble IL-21R (or binding fragments of...
Published: 10/28/2024   |   Inventor(s): Thomas Wynn
Keywords(s): Asbestosis, CB1AXX, CB1XXX, CB6XXX, CBXXXX, CXXXXX, Cystic fibrosis, DEFICIENCY, FIBROSIS, Hepatitis A, Hepatitis D, Hepatitis E, IL-21, Immunity, Inflammmation, Patent Category - Biotechnology, RECEPTOR, REDUCES, SCHISTOSOMIASIS, Schistosomiasis (Schistosoma sp.), Scleroderma, Scleroderma, systemic, Tissue, TYPE-2
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, TherapeuticArea > Oncology, Application > Therapeutics
Live Tissue Imaging Gel
The National Heart Lung and Blood Institute (NHLBI), Laboratory of Cardiac Energetics, has created a gel with 0.3%-0.5% carbomer 940 which is easily used as an imaging immersion medium for confocal and two photon fluorescence emission microscopy and second harmonic generation imaging. This thick, but transparent, gel can be layered on tissue for microscopic...
Published: 4/8/2024   |   Inventor(s): Robert Balaban
Keywords(s): AC3XXX, AC5XXX, ACXXXX, AXXXXX, Gel, IMAGING, Live, Tissue
Category(s): Collaboration Sought > Licensing
Surgical Apparatus for Cutting Tissue
Title: Single surgical instrument uses unique design for cutting membranes covering tissue.Current State of the Art: There are several surgical procedures that require the cutting and re-positioning of a membrane in order to access the underlying tissues. These include but are not limited to the dura mater of the brain and spinal cord. To perform these...
Published: 9/18/2020   |   Inventor(s): Cargill Alleyne
Keywords(s): Spinal, Surgery, Tissue
Category(s): Medical Devices
Bottom-Up Tissue Regeneration Scaffold That Rebuilds Tissue Where It Is Needed
Supports Layered Cell Regrowth, Tissue Repair, Fluid Perfusion and Wound Healing to Replace Injured Bone, Muscle and Skin TissuesThis tissue regeneration platform facilitates the layered regrowth of cells to heal traumatic wounds and other injuries by growing bone, muscle, and skin tissues right where they are needed. Regenerative medicine, in which...
Published: 6/27/2021   |   Inventor(s): Adam Katz
Keywords(s): Angiogenesis, diffusion, Engineering, microfluidics, regeneration, stem cells, Tissue, Tissue Engineering
Category(s): Technology Classifications > Engineering, Technology Classifications > Human Health Care, Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Medical Devices
Injectable Microengineered Tissues for Cardiac Regeneration
Each year, millions of patients, globally, suffer from heart failure and cardiovascular disease. Stem cell transplantation and tissue engineering strategies have tremendous potential for repair and/or regeneration of injured myocardium. The major hurdles in stem cell transplantation are poor cell survival, insufficient cardiogenic differentiation,...
Published: 12/10/2024   |   Inventor(s): Mehdi Nikkhah, Brent Vernon
Keywords(s): Biological Cell Manipulation, Cell Culture, MEMS, Tissue, Tissue Repair
Category(s): Life Science (All LS Techs), Biomaterials, Advanced Materials/Nanotechnology, Non-Cancer Therapeutics