Search Results - life+science+research+tools+%3e+research+methods

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Cohesive CLEM, TEM, FEBSEM System for MicroED and Cryo-EM Applications (Case No. 2025-010)
Summary UCLA researchers have developed a cohesive electron microscope system that uniquely integrates transmission electron microscopy (TEM), fluorescence microscopy, and focused ion beam scanning electron microscopy (FIB-SEM) into a single automated column. The platform supports both cryogenic and room-temperature workflows, enabling fully automated...
Published: 9/12/2025   |   Inventor(s): Tamir Gonen, Michael Martynowycz
Keywords(s):  
Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Research Methods, Medical Devices, Medical Devices > Medical Imaging, Platforms
Discrete Approximation of Permanent Magnet Arrays (Case No. 2025-203)
Summary UCLA researchers have developed Discrete-MAG, a discrete magnetic actuation / magnetics platform that delivers precise, programmable magnetic field manipulation at small scales. The system aims to control magnetic particles or micro-devices discretely for applications in sensing, actuation, imaging, or biological interfacing. Background Magnetic...
Published: 9/16/2025   |   Inventor(s): Tyler Clites, He Kai Lim, Will Flanagan, Cameron Taylor
Keywords(s):  
Category(s): Materials, Materials > Functional Materials, Medical Devices, Mechanical, Mechanical > Robotics, Platforms, Platforms > Drug Delivery, Medical Devices > Medical Imaging, Life Science Research Tools, Life Science Research Tools > Research Methods
Methods for Automation and Compositional Analyses of MicroED Data (Case No. 2023-256)
Summary UCLA researchers have developed an automated Microcrystal Electron Diffraction (MicroED) microscopy system and method that autonomously identifies, images, and analyzes micro-crystals on an EM grid. The system captures low-magnification atlases, selects promising grid squares, acquires higher-magnification montages, sets focus, captures continuous-rotation...
Published: 9/11/2025   |   Inventor(s): Tamir Gonen, Johan Unge
Keywords(s):  
Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods
Synthetic Notch Receptors for Use in Customized Spatial Control of Multiple Gene Expressions and Uses Thereof (UCLA Case No. 2023-261)
Researchers at UCLA and USC have developed a modular invention that enables customized spatial control of multiple gene expressions in living cells using synthetic Notch (synNotch) receptors, with broad applications in tissue engineering, synthetic morphogenesis, and regenerative medicine. BACKGROUND: Precise spatial control of gene expression is fundamental...
Published: 9/11/2025   |   Inventor(s): Song Li
Keywords(s):  
Category(s): Platforms, Life Science Research Tools > Research Methods
Physical Separation of Ultrashort Single-Stranded Cell-Free DNA in Biofluids Using Differential Filtration and Next-Generation Sequencing Pipeline to Detect Methylation Status of Ultrashort Single-Stranded Cell-Free DNA (UCLA 2023-077, 2023-082)
UCLA researchers in the Department of Dentistry have established novel extraction and bioinformatics pipeline of ultrashort single-stranded cell-free DNA for the use in liquid biopsy diagnostics. BACKGROUND: Liquid biopsy is a critical diagnostic tool for various human diseases. The rapid market growth of liquid biopsy is primarily driven by novel...
Published: 9/11/2025   |   Inventor(s): David Wong, Jordan Cheng
Keywords(s): Cancer, cell-free DNA, circulating DNA, Diagnostic Markers & Platforms, DNA methylation, liquid biopsy, next generation sequencing (NGS)
Category(s): Software & Algorithms > Bioinformatics, Life Science Research Tools > Research Methods, Platforms > Diagnostic Platform Technologies
Analysis of Ultrashort Single-Stranded Cell-Free DNA in Patient Saliva for Disease Detection (UCLA Cases 2022-292, 2022-043)
UCLA researchers have developed a novel next-generation sequencing (NGS) pipeline designed specifically to detect ultrashort single-stranded cell-free DNA (uscfDNA), providing significant advancements in sensitivity, clinical utility, and genomic research applications. Background: Cell-free DNA (cfDNA) fragments circulate in body fluids and have become...
Published: 9/11/2025   |   Inventor(s): David Wong, Jordan Cheng
Keywords(s):  
Category(s): Life Science Research Tools > Research Methods, Platforms > Diagnostic Platform Technologies
SYSTEM AND METHOD FOR IN VIVO DETECTION OF BIOMOLECULES IN TISSUES, ORGANS AND EXTRACELLUAR FLUID
Summary A minimally invasive electrochemical sensing platform that places tiny electrodes in or near target tissues (e.g., heart, nerves, vessels) to continuously detect specific biomolecules—including catecholamines and peptides—with high spatial and temporal resolution. This enables real-time physiologic monitoring and closed-loop therapies...
Published: 9/10/2025   |   Inventor(s): Kalyanam Shivkumar, Corey Smith, Jeffrey Ardell
Keywords(s):  
Category(s): Medical Devices, Life Science Research Tools, Life Science Research Tools > Research Methods
Methods for Generating Spatially Resolved Genomic Profiles From Tissues (UCLA Case No. 2022-112)
UCLA researchers in the Department of Human Genetics have developed a scalable, high-precision in situ spatial barcoding method, enabling spatially-resolved single-cell and subcellular genomic profiling, including transcriptomics and epigenomics, with targeted cell selection guided by immunofluorescence. BACKGROUND: Recent advancements in spatial transcriptomics...
Published: 7/17/2025   |   Inventor(s): Chongyuan Luo
Keywords(s):  
Category(s): Life Science Research Tools > Research Methods
Subgraph Matching for High-Throughput DNA-Aptamer Secondary Structure Classification and Machine Learning Interpretability (Case No. 2025-104)
Intro Sentence: UCLA researchers in the Department of Mathematics have developed machine learning methods to rapidly identify novel aptamer sequences for target binding to accelerate highly-accurate diagnostic and therapeutic development. Background: Aptamers are single-stranded nucleotide polymers that bind with high affinity to targets such as...
Published: 8/19/2025   |   Inventor(s): Andrea Bertozzi, Anne Andrews, Matthew Tyler, Paolo Climaco, Noelle Mitchell
Keywords(s): Advanced Computing / AI, advanced computing methods, Aptamers, Artifical Intelligence (Machine Learning, Data Mining), artificial intelligence/machine learning models, bioinformatics pipeline, cancer target, clustering, computational efficiency, computational efficiency and analysis, design software, DNA clustering, DNA oligomer, DNA Sequencing, Drug, Drug Delivery, Drug Development, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, interpretability, pipeline, large-scale parallelization, Machine Learning, machine learning modeling, motif structures, open source, open source code, OpenAI, Pharmaceutical Drug, protein classification, secondary structure, SELEX, sequences of interest, single strand DNA sequences, Software, Software & Algorithms, Software Development Tools, Software-enabled learning, subgraph matching, target binding, target detection, Targeted Therapy, Targets And Assays, tissue targeting accuracy
Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Data Analytics, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Screening Libraries, Platforms, Platforms > Drug Delivery, Diagnostic Markers > Targets And Assays, Diagnostic Markers, Software & Algorithms > Bioinformatics
Targeting the Bile Acid Pathway to Treat Cardiometabolic Disease (UCLA Case No. 2024-146)
UCLA researchers from the Department of Medicine and Division of Cardiology have identified target enzymes involved in bile acid synthesis and developed methods to improve disease outcomes in fatty liver and atherosclerosis. BACKGROUND: Dietary fat is an essential, energy-dense nutrient necessary for survival. To support this, the intestinal system...
Published: 7/17/2025   |   Inventor(s): Thomas Vallim
Keywords(s):  
Category(s): Life Science Research Tools > Screening Libraries, Therapeutics > Gastroenterology, Therapeutics > Metabolism And Endocrinology, Life Science Research Tools > Research Methods, Therapeutics > Cardiovascular
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