Search Results - life+science+research+tools+%3e+research+methods

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Copyright: Locally Low-Rank Image Denoising for Multi-Coil Multi-Contrast Magnetic Resonance Imaging (Case No. 2025-056)
Summary: UCLA researchers have developed a software algorithm for locally low-rank denoising that improves image quality and diagnostic reliability in multi-coil, multi-contrast MRI by correcting complex noise and preserving fine image details. Background: Magnetic resonance imaging (MRI) is a powerful, non-invasive tool widely used in both research...
Published: 12/1/2025   |   Inventor(s): Shu-Fu Shih, Holden Wu
Keywords(s): 3D tissue imaging, AI-guided medical imaging, Biomedical Engineering, Cardiac MRI, Cine MRI, Deep learning MRI, DENSE MRI, Imaging, Magnetic Resonance Imaging, Magnetic Resonance Imaging Carotid Artery Stenosis, Magnetic Resonance Imaging Hypoxia (Medical), Magnetic Resonance Imaging Medical Physics, Magnetic Resonance Imaging Microangiopathy, Magnetic Resonance Imaging Pathology, Magnetic Resonance Imaging Spin Polarization, Medical artificial intelligence (AI), Medical Device, Medical Devices and Materials, Medical diagnostics, Medical Imaging, MRI, multiparametric MRI (mpMRI), radial MRI
Category(s): Electrical > Imaging, Electrical > Signal Processing, Life Science Research Tools > Research Methods, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Software & Algorithms > Image Processing, Software & Algorithms
Silyl Ether Enables Chemoproteomic Interaction and Target Engagement (SEE-CITE) (UCLA Case No. 2024-194)
UCLA researchers from the Department of Biological Chemistry have developed a chemoproteomic platform for high-coverage, site-specific mapping of small-molecule–protein interactions using a cleavable silyl ether–based photoaffinity probe design. BACKGROUND: Small molecule drugs rely on specific and selective interactions with protein targets...
Published: 11/4/2025   |   Inventor(s): Keriann Backus
Keywords(s):  
Category(s): Life Science Research Tools > Mass Spectrometry, Life Science Research Tools > Research Methods, Therapeutics > Oncology
Directed Differentiation Protocols to Derive Bone Fide Spinal Sensory Interneurons (UCLA Case No. 2022-224)
UCLA researchers from the Department of Neurobiology have developed innovative protocols to differentiate and expand spinal sensory interneurons for drug discovery and to utilize in cell replacement therapies to restore injured spinal cords. BACKGROUND: Spinal cord injuries (SCIs) can result in the loss of controlled movement and somatosensation, the...
Published: 10/10/2025   |   Inventor(s): Samantha Butler
Keywords(s):  
Category(s): Life Science Research Tools > Research Methods, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > CNS and Neurology
Interactive Systems and Methods for Identifying Target Proteins in Drug Discovery (Case No. 2025-098)
Summary: UCLA researchers from the Department of Electrical and Computer Engineering have developed a novel computational system for target protein identification, enabling integrative drug discovery. Background: Target identification (Target ID) in drug discovery involves the identification and evaluation of protein candidates that could interact...
Published: 10/1/2025   |   Inventor(s): Xiang Chen, Youngseung Jeon, Christopher Hwang, Ziwen Li, Jesus Campagna, Varghese John, Whitaker Cohn, Eunice Jun
Keywords(s): AI-driven drug discovery, Alzheimer’s disease target discovery, Bioinformatics software platform, Drug, Drug Discovery, Functional annotation of proteins, High-throughput docking, large language models (LLMs), Ligand-protein docking, Mechanism-of-action prediction, Molecular docking simulation, Multi-criteria decision support, Neurodegenerative disease therapeutics, Pathway-centric drug targeting, personalized medicine, PPI-Comparator, PPI-Explorer, Protein structure prediction, Protein-protein interaction (PPI) analysis, Rational drug design, Retrieval-augmented generation (RAG), Semantic similarity modeling, Small molecule screening, Systems biology interface, Target identification (Target ID), Therapeutic impact modeling, User-guided AI exploration
Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Digital Health, Life Science Research Tools, Life Science Research Tools > Research Methods, Platforms, Platforms > Drug Delivery
Pulsed Laser Triggered High Speed Microfluidic Switch and Applications in Flourescent Activated Cell Sorting (Case No. 2009-063)
Summary UCLA researchers have developed a pulsed-laser triggered microfluidic switching mechanism capable of sub-100 µs switching (e.g. ~70 µs), enabling ultrafast cell/particle sorting in a microfluidic fluorescence-activated cell sorting (µFACS) platform using cavitation bubbles rather than mechanical valves. Background Flow cytometry...
Published: 9/25/2025   |   Inventor(s): Pei-Yu Chiou, Ting Hsiang Wu
Keywords(s):  
Category(s): Optics & Photonics, Optics & Photonics > Lasers, Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Research Methods
Pulse Laser Driven High Speed, On-Demand, and Multiplexed Droplet Generator (Case No. 2013-184)
Summary UCLA researchers have developed a high-speed, on-demand microfluidic droplet platform that allows rapid and precise generation, manipulation, and merging of microdroplets for advanced lab-on-a-chip applications. The technology enables controlled droplet initiation and synchronized merging at high throughput, making it a versatile platform for...
Published: 9/24/2025   |   Inventor(s): Pei-Yu Chiou, Michael Teitell, Ting Hsiang Wu, Yue Chen, Yu Chun Kung
Keywords(s):  
Category(s): Optics & Photonics, Optics & Photonics > Lasers, Life Science Research Tools, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Research Methods, Life Science Research Tools > Cell Counting And Imaging
An Organometallic Chemistry Approach to Peptide Tricycles (UCLA Case No. 2025-99O)
Contact UCLA Technology Development Group to learn more. Preprint: Adhami N, Rebelo M, Jenkins R, Olivares E, Loo R, Qu S, et al. An Organometallic Chemistry Approach to Peptide Tricycles. ChemRxiv. 2025; doi:10.26434/chemrxiv-2025-mkz71
Published: 9/19/2025   |   Inventor(s): Alexander Spokoyny
Keywords(s):  
Category(s): Life Science Research Tools > Research Methods
Methods for Determining Drug-Target Structures by Combining Mass Spectrometry and Electron Diffraction (UCLA Case No. 2025-229)
UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel approach to study protein-ligand interactions by integrating native mass spectrometry with electron diffraction. BACKGROUND: The accurate characterization of small molecule-protein interactions is crucial for biomedical research. High-throughput structural methods,...
Published: 10/29/2025   |   Inventor(s): Jose Rodriguez
Keywords(s):  
Category(s): Life Science Research Tools, Life Science Research Tools > Mass Spectrometry, Chemical > Synthesis, Chemical > Chemical Sensors, Chemical > Chemical Processing & Manufacturing, Chemical > Instrumentation & Analysis, Diagnostic Markers > Targets And Assays, Electrical > Sensors, Electrical > Instrumentation, Life Science Research Tools > Research Methods, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Screening Libraries, Life Science Research Tools > Lab Equipment, Mechanical > Sensors, Mechanical > Instrumentation, Optics & Photonics > Microscopy, Optics & Photonics > Spectroscopy
Method for Scalable Spatially Resolved Molecular Recording (UCLA Case No. 2025-049)
Contact UCLA Technology Development Group to learn more. Keywords: spatially resolved omics technologies, transcriptomics, genomics, spatial molecular recording
Published: 9/17/2025   |   Inventor(s): Amjad Askary
Keywords(s):  
Category(s): Life Science Research Tools > Research Methods
Cohesive CLEM, TEM, FEBSEM System for MicroED and Cryo-EM Applications (Case No. 2025-010)
Summary UCLA researchers have developed a cohesive electron microscope system that uniquely integrates transmission electron microscopy (TEM), fluorescence microscopy, and focused ion beam scanning electron microscopy (FIB-SEM) into a single automated column. The platform supports both cryogenic and room-temperature workflows, enabling fully automated...
Published: 10/24/2025   |   Inventor(s): Tamir Gonen, Michael Martynowycz
Keywords(s):  
Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Research Methods, Medical Devices, Medical Devices > Medical Imaging, Platforms
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