Search Results - dna+methylation

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Physical Separation of Ultrashort Single-Stranded Cell-Free DNA in Biofluids Using Differential Filtration and Next-Generation Sequencing Pipeline to Detect Methylation Status of Ultrashort Single-Stranded Cell-Free DNA (UCLA 2023-077, 2023-082)
UCLA researchers in the Department of Dentistry have established novel extraction and bioinformatics pipeline of ultrashort single-stranded cell-free DNA for the use in liquid biopsy diagnostics. BACKGROUND: Liquid biopsy is a critical diagnostic tool for various human diseases. The rapid market growth of liquid biopsy is primarily driven by novel...
Published: 7/1/2024   |   Inventor(s): David Wong
Keywords(s): Cancer, cell-free DNA, circulating DNA, Diagnostic Markers & Platforms, DNA methylation, liquid biopsy, next generation sequencing (NGS)
Category(s): Software & Algorithms > Bioinformatics, Life Science Research Tools > Research Methods, Platforms > Diagnostic Platform Technologies
A Novel Transgenic Zebrafish Line Reporting Dynamic Epigenetic Changes
Abstract: Currently, there is no other whole-animal reporter for epigenetic regulation established in any vertebrate.  The inventors generated this novel zebrafish line using a transgene construct containing dazl gene silencing sequences (CpG island) fused to a destabilized GFPd2 gene driven by the ubiquitously expressing ef1alpha promoter. The resulting...
Published: 4/8/2024   |   Inventor(s): Aniket Gore, Brant Weinstein
Keywords(s): Development, DNA Methylation, Epigenetic Silencing, Eunice Kennedy Shriver National Institute of Child Health an, GFPd2, NICHD, Tissue-specific Expression, Weinstein, Zebrafish
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology
Test Kit that Simultaneously Measures DNA Methylation and Chromatin Structure to Identify Cancer and Other Diseases
Integrates DNA Methylation and Chromatin Structure Assessment to Better Predict Chance of DiseaseThis integrated DNA test kit helps diagnose disease by measuring methylation and chromatin structure at the same time, giving it an edge over disease detection kits that employ separate evaluations. Locked inside every tissue sample is valuable information...
Published: 6/27/2021   |   Inventor(s): Michael Kladde, Nancy Nabilsi, Carolina Pardo
Keywords(s): Chromatin, DNA Methylation, Epigenetics
Category(s): Technology Classifications > Research Tools > Others
Polyclonal Antibody to DNA Methyltransferase (DNMT1)
Targeting a Protein That Methylates DNA Scientists at the University of Florida have developed a wide variety of monoclonal and polyclonal antibodies, cell lines, vectors and biological materials that can be used in other research projects. Anyone interested in accessing these materials via a license from the University of Florida should contact our...
Published: 6/27/2021   |   Inventor(s): Keith Robertson
Keywords(s): Antibody, Chromatin, DNA Methylation, DNMT1, Gene Regulation, Immunoprecipitation, Western Blotting
Category(s): Technology Classifications > Research Tools > Biological Materials, Technology Classifications > Research Tools > Diagnostics, Technology Classifications > Research Tools > Therapeutics