Search Results - liquid+biopsy

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Physical Separation of Ultrashort Single-Stranded Cell-Free DNA in Biofluids Using Differential Filtration and Next-Generation Sequencing Pipeline to Detect Methylation Status of Ultrashort Single-Stranded Cell-Free DNA (UCLA 2023-077, 2023-082)
UCLA researchers in the Department of Dentistry have established novel extraction and bioinformatics pipeline of ultrashort single-stranded cell-free DNA for the use in liquid biopsy diagnostics. BACKGROUND: Liquid biopsy is a critical diagnostic tool for various human diseases. The rapid market growth of liquid biopsy is primarily driven by novel...
Published: 7/1/2024   |   Inventor(s): David Wong
Keywords(s): Cancer, cell-free DNA, circulating DNA, Diagnostic Markers & Platforms, DNA methylation, liquid biopsy, next generation sequencing (NGS)
Category(s): Software & Algorithms > Bioinformatics, Life Science Research Tools > Research Methods, Platforms > Diagnostic Platform Technologies
Non-invasive diagnostic and prognostic assay for early stage lung cancer
Abstract: In the United States alone, one of four cancer deaths occur from lung cancer and there are over 8 million individuals considered to be at high-risk due to cigarette smoking and other behaviors. It's well known that early detection of cancer significantly improves survival of this disease, however a lack of lung cancer screenings and analysis...
Published: 4/8/2024   |   Inventor(s): Curtis Harris, Ewy Mathe, Frank Gonzalez, Kristopher Krausz, Soumen Manna, Andrew Patterson, Majda Haznadar
Keywords(s): LDCT, LD-CT, liquid biopsy, low-dose computed tomography, Non-small cell lung cancer, NSCLC, Urine
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Diagnostics, Collaboration Sought > Licensing
Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing.
Transfer RNAs (tRNAs) play a central role in protein translation. Studying them has been difficult in part because a simple method to simultaneously quantify their abundance and chemical modifications is lacking. Here we introduce Nano-tRNAseq, a nanopore-based approach to sequence native tRNA populations that provides quantitative estimates of both...
Published: 9/29/2023   |   Inventor(s): Eva Novoa, Morghan Lucas, Leszek Pryszcz, Rebeca Medina Azmecua
Keywords(s): Algorithms, Bioinformatics, Biomarkers, Diagnostics, Liquid Biopsy, Oncology
Category(s): Methodology, Software & Algorithms