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Search Results - dermatology
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Improving Diagnosis and Treatment of Sarcoidosis
Using a blood or tissue biomarker to improve diagnosis and identification of a new targeted treatment. Problem: Sarcoidosis is an inflammatory disease that can affect any organ, predominantly the lung, skin, and the lymphatic system. Symptoms include difficulty breathing, extreme fatigue, skin inflammation, and joint pain. Sarcoidosis compromises patients’...
Published: 12/5/2024
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Inventor(s):
Thomas Hin-Chai Leung
,
Satish Sati
,
Misha Rosenbach
Keywords(s):
Dermatology
,
Immunology
,
Inflammation
,
Ophthalmology
,
Pulmonary
Category(s):
Technology Classifications > Diagnostics
Targeting TANGO-1 as a Treatment for Fibrosis (TARTF)
Collagen secretion inhibition in cell and mouse models of fibrosis Compounds that inhibit the formation of the collagen endoplasmic reticulum (ER)-exit machinery in fibroblasts reducing collagen secretion. They can be used for treating fibrotic diseases by targeting the key, common pathological issue, collagen secretion. Technology: Fibrosis underpins...
Published: 11/11/2024
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Inventor(s):
Vivek Malhotra
,
Ishier Raote
,
Thomas Krieg
,
Beate Eckes
,
Ines Neundorf
Keywords(s):
Dermatology
,
Fibrosis
,
Respiratory Tract Diseases
Category(s):
Drug Targets & Mechanisms
,
Therapeutics (Biologics & Compounds)
Novel topical formulation of Cyclosporine
Patient outcome: Left- 79-year-old patient after 3.5 months. Right- 50-year-old patient after 4 weeks of treatment with the novel formulation. Ref: JAAD Case Rep. 2023 Aug 20;40 Invention Summary: Pyoderma Gangrenosum (PG) is a rare, acute inflammatory skin disorder characterized by the rapid development of large, painful ulcers. PG frequently...
Published: 9/26/2024
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Inventor(s):
Amy Pappert
,
Cindy Wassef
,
Radhika Shah
Keywords(s):
Dermatology
Category(s):
Technology Classifications > Healthcare & Life Sciences
Indolium 1 for Advanced Melanoma Treatment
Application A small molecule compound for the treatment of melanoma. Key Benefits Novel small molecule compound for the treatment of resistant melanoma. Well tolerated in vivo. Market Summary Malignant melanoma is a type of skin cancer that begins in melanocyte cells. Melanoma is the 19th most commonly occurring cancer. Exposure to UV radiation...
Published: 12/4/2024
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Inventor(s):
Jack Arbiser
Keywords(s):
Dermatology
,
Oncology
,
Small Molecule
Category(s):
TechPub Algolia > Therapeutics
Topical LSD1 Inhibition for Treating Skin Diseases
Topical LSD1 inhibition can treat skin diseases that include cutaneous squamous cell carcinoma (cSCC), actinic keratoses, and viral warts. Problem: Current treatment options (i.e. cryotherapy, laser therapy, surgery, chemotherapy) for skin diseases such as cSCC, actinic keratoses, and viral warts are often non-targeted and destructive, and can cause...
Published: 2/12/2024
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Inventor(s):
Brian Capell
,
Napasorn (Nina) Kuprasertkul
Keywords(s):
Dermatology
,
Drug Delivery
,
Drug Target
,
Immunoncology
,
Oncology
Category(s):
Technology Classifications > Therapeutics
Targeted light-based therapy for acne
Summary Acne is the most common skin condition, with direct treatment costs totaling over $3 billion each year. Vanderbilt researchers have developed a photodynamic therapy (PDT) for effectively and specifically treating Propionibacterium acnes infections, enabling improved clinical support for patients. Addressed Need More than 90% of the global...
Published: 9/4/2024
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Inventor(s):
Keywords(s):
Dermatology
,
Infectious Disease
Category(s):
Therapeutics
Stretchable, Adhesive, and Self-Healing Hydrogels for Next-Generation Medical Adhesives
A hydrogel that can naturally stretch and self-heal while adhering to the body, enabling new designs for medical adhesives. Problem: Hydrogels are naturally biocompatible materials which could revolutionize diverse medical technologies ranging from artificial muscles to wearable electronics. Their simple non-toxic composition along with their non-rigid...
Published: 10/16/2023
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Inventor(s):
Shu Yang
,
Mingtao Chen
,
Baohong Chen
Keywords(s):
Bioengineering
,
Dermatology
,
Hydrogels
,
Soft Materials
Category(s):
Technology Classifications > Medical Devices
,
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Materials
Targeted photodynamic therapy for S. aureus infections
Summary Staphylococcus aureus is among the most prevalent pathogens in skin and soft tissue infections, with treatments becoming increasingly compromised by the emergence of methicillin-resistant S. aureus (MRSA). Vanderbilt researchers have developed a combination photodynamic therapy (PDT) for targeting MRSA infections in skin that is not only effective...
Published: 8/9/2023
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Inventor(s):
Keywords(s):
Dermatology
,
Infectious Disease
Category(s):
Therapeutics
PKC412 restores functionality of the keratin cytoskeleton in the skin disorder epidermolysis bullosa simplex
Invention Summary: Epidermolysis bullosa simplex (EBS) is a highly penetrant genetic condition that causes fragility of skin keratinocytes resulting in fluid-filled skin blisters that erode upon scratching or minor pressure on the skin. There is no good cure for EBS, and treatment typically involves preventive and/or supportive care...
Published: 10/21/2024
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Inventor(s):
Bishr Omary
,
Thomas Magin
,
Jacques Roberge
,
Katrin Rietscher
,
Pei Li
Keywords(s):
Dermatology
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Rare Disease
2012-340 A Novel Basic Fibroblast Growth Factor Conjugate for Broad Therapeutic Application
A Novel Basic Fibroblast Growth Factor Conjugate for Broad Therapeutic ApplicationSUMMARYUCLA scientists have developed a novel polymer conjugate of basic fibroblast growth factor (bFGF) for use in commercial and possibly clinical applications. This is the first bFGF conjugate to enhance bioactivity and stability under environmental stressors. BACKGROUNDBasic...
Published: 7/19/2023
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Inventor(s):
Heather Maynard
,
Thi Nguyen
Keywords(s):
Catalysts
,
Dermatology
,
Other Polymers
,
Therapeutics & Vaccines
Category(s):
Chemical > Synthesis
,
Therapeutics
,
Therapeutics >
Dermatology
,
Platforms > Drug Delivery > Other Polymers
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