Search Results - malay+haldar

3 Results Sort By:
Tumor Suppression by Retinoic Acid Pathway Inhibition
­Targeting retinoic acid (RA) synthesizing enzymes or RA receptors with small molecules boosts the immune system towards a tumor rejection response Problem: Hepatocellular carcinoma (HCC) is the most common liver cancer globally. In the US alone, 33 000 patients are diagnosed yearly, 27 000 of which will die. Once metastasized, HCC shows...
Published: 6/21/2024   |   Inventor(s): Malay Haldar, Ganesha Rai Bantukallu
Keywords(s): Cell Therapy, Drug Target, Immunology, Immunoncology, Oncology, Small Molecule
Category(s): Technology Classifications > Therapeutics
Star, Branched, and Graft Polymers in Binders for Inkjet Additive Manufacturing for Personalized Dosage Tablets
THE CHALLENGE A major problem posed by the pharmaceutical industry is giving effective dosages while not giving excessive amounts of a particular drug. An estimated 80% of side effects in humans and animals are a direct result of inaccurate dosing because varying weights in patients. Additive manufacturing has emerged as a very promising method to...
Published: 1/31/2024   |   Inventor(s): Emily Wilts, Timothy Long, Christopher Williams, Da Ma
Keywords(s):  
Category(s): Technology Classifications > Additive Manufacturing, Technology Classifications > Biomedical, Technology Classifications > Chemicals/Materials, Technology Classifications > Pharmacology and Therapeutics
Targeting the Retinoic Acid Pathway to Bolster Immunotherapy
A strategy to increase the effect of immune checkpoint blockade by targeting retinoic acid signaling in immunosuppressive solid tumors. Technology Overview: Sarcomas are solid tumors with more than 70 rare and often fatal subtypes. Typical survival rates are under 15% over 5 years. Sarcomas can prevent the formation of tumor-killing cells by eluding...
Published: 9/18/2024   |   Inventor(s): Malay Haldar, Samirkumar Devalaraja
Keywords(s): Immunotherapy
Category(s): Technology Classifications > Therapeutics