Search Results - robert+williams

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Microneedle array coating technology for enhanced stability and targeted delivery of mRNA and biologics
A microneedle-based system uses cryogenically pre-cooled needles coated via thin-film freeze-coating to preserve mRNA stability, enabling efficient, multi-therapeutic intradermal delivery of temperature-sensitive drugs. Background The field of advanced drug delivery systems has grown substantially as the biomedical industry grapples with the complexities...
Published: 1/27/2026   |   Inventor(s): Zhengrong Cui, Michael Sandoval, Robert Williams, Drew Weissman, Qin Li
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug discovery
Dry powder cell formulations for long-term viability and therapeutic applications
This technology stabilizes eukaryotic cells by mixing them with sugars, antioxidants, polymers, and optionally proteins, then rapidly freezing and freeze-drying them to create a dry powder that maintains high cell viability for long-term storage. Background The field of biopreservation and cell therapy is fundamentally challenged by the need to maintain...
Published: 1/27/2026   |   Inventor(s): Zhengrong Cui, Mahmoud Hanafy, Robert Williams
Keywords(s):  
Category(s): Life sciences > Research tools
KinetiSol powder ejection for low-temperature formulation of thermolabile APIs
Background Many emerging drug candidates suffer from poor aqueous solubility and heat sensitivity, making them difficult to formulate using conventional manufactur­ing techniques. These challenges are especially problematic for inhalation and nasal drug delivery, where fine particle size and chemical stability are essential for therapeutic performance. Existing...
Published: 1/27/2026   |   Inventor(s): Robert Williams, Miguel Jara Gonzalez, Beatriz Behrend, Daniel Davis, Dave Miller
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Thin film freezing technology for stable dry formulations of mRNA therapeutics
A thin film freezing method transforms mRNA and lipid nanoparticles into stable dry powders that retain their effectiveness and size. This eliminates the need for ultra-cold storage, allowing the powders to be inhaled or reconstituted, improving the distribution of mRNA therapies. Background mRNA therapeutics represent a groundbreaking advancement...
Published: 1/13/2026   |   Inventor(s): Robert Williams, Chaeho Moon, Sawittree Sahakijpijarn, Haiyue Xu, Zhengrong Cui
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Therapeutics > Drug delivery
Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025   |   Inventor(s): Li Li, Shichao Wu, Jiawei Zhao
Keywords(s):  
Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic
Solvent-free enhanced 3D printing of biologics
Background/problem 3D printing holds great potential for creating personalized medication and pharmaceutical dosage forms. However, it faces challenges when using powder bed-based technologies like Selective Laser Sintering (SLS) and Binder Jetting. These methods require powders with excellent flow characteristics to function smoothly. This is a straightforward...
Published: 1/13/2026   |   Inventor(s): Mohammed Maniruzzaman, Joseph Beaman, Robert Williams, Timothy Phillips, Rishi Thakkar, Amit Pillai, Daniel Davis
Keywords(s):  
Category(s): Life sciences > Research tools
Advanced nanoparticle delivery system for targeted pulmonary administration of therapeutic nucleic acids
Lipid nanoparticles (LNPs) are designed for delivering RNA to lung tissues via inhalation. Composed of ionizable lipids, phospholipids, PEG-lipids, and cholesterol, they encapsulate RNA for therapeutic or immunological purposes, maintaining stability during nebulization. Background Gene therapy and editing hold significant promise for treating genetic...
Published: 1/13/2026   |   Inventor(s): Hugh Smyth, Hairui Zhang, Robert Williams
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery
Individualized intranasal delivery system for direct pharmaceutical administration to the brain
The technology involves a customizable nasal delivery device for precise administration of medications directly to the brain, bypassing traditional barriers. It uses imaging techniques for optimal placement, enhancing drug delivery efficiency and minimizing systemic side effects. Background Oral administration remains the predominant method for drug...
Published: 1/13/2026   |   Inventor(s): Hugh Smyth, Robert Williams, Zachary Warnken, Yang Lu
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Medical technology > Medical devices
Advanced hot melt extrusion (HME) technology with reduced decomposition
The technology involves using hot melt extrusion (HME) to prepare amorphous drug formulations with reduced decomposition. This method incorporates a pharmaceutically acceptable thermoplastic polymer and an organic solvent to lower processing temperatures and stress, ensuring drug stability. Background HME is a widely used technique in the pharmaceutical...
Published: 1/13/2026   |   Inventor(s): Feng Zhang, Robert Williams, Abbe Miller, Siyuan Huang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug discovery, Life sciences > Biomaterials
Enzyme delivery for lung injuries and infections using nebulized solutions and perfluorocarbons
The technology describes methods and compositions for treating lung injuries and infections by delivering enzymes, such as plasminogen activators, to the airway using nebulized solutions and perfluorocarbon carriers. This approach dissolves airway obstructions and supports respiratory function. Background Acute lung injury (ALI) and its severe form,...
Published: 1/13/2026   |   Inventor(s): Robert Williams, Steven Idell
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
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