Search Results - debadyuti+ghosh

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Blood-brain barrier penetrating peptides
Problem Effective delivery of therapeutics into the brain is challenging, due to biological barriers including the blood-brain barrier (BBB), the perivascular space, cerebrospinal fluid, and the extracellular matrix. Drugs that can cross the BBB may be delivered intravenously; for drugs that cannot penetrate the BBB, intrathecal or local administration...
Published: 12/19/2023   |   Inventor(s): Debadyuti Ghosh, Xiujuan Peng
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
Stably aerosolized mRNA for lung delivery
Problem Nucleic acid therapy has the potential to treat genetic diseases that affect the lungs. Localized delivery of nucleic acid cargos allows for higher doses than are achievable with systemic delivery and avoids both toxicity and off-target effects. One reason nucleic acid therapeutics have not yet achieved clinical approval for delivery to the...
Published: 11/1/2023   |   Inventor(s): Debadyuti Ghosh, Mae Lewis
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery
Lung mucus-penetrating peptides
Problem Nucleic acid therapy has the potential to treat genetic diseases that affect the lungs. In order to effectively deliver genetic material to lung cells, gene delivery systems must be able to overcome the mucus barrier and directly target cells harboring the genetic mutation causing the disease state. Past efforts have focused to penetrate the...
Published: 4/19/2024   |   Inventor(s): Debadyuti Ghosh, Melissa Soto
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Therapeutics > Drug delivery
Improved drug delivery for solid tumors
A novel formulation paving the way for pancreatic cancer therapeutics Problem Pancreatic cancer therapeutics have a success rate of less than 8%. The solid nature of the tumor in pancreatic cancer renders the current standard of care, chemotherapy drugs, less effective. Unfortunately, the problem lies not with the drugs themselves, but with the drug...
Published: 11/1/2023   |   Inventor(s): Debadyuti Ghosh, Xinquan Liu
Keywords(s): Cancer, Drug delivery, Drug development, Drugs, Pharmaceuticals
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Biologic