Search Results - hugh+smyth

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Optimized inhalation formulation of clofazimine and amikacin for targeted treatment of respiratory infections

The invention describes a pharmaceutical composition combining clofazimine and amikacin for inhalation to treat respiratory diseases like tuberculosis. This formulation enhances drug delivery to the lungs, improving efficacy and reducing systemic side effects. Background Bacterial infections, particularly those caused by mycobacteria such as Mycobacterium...

Published: 10/15/2024 | Inventor(s): Hugh Smyth, Ashlee Brunaugh

Keywords(s):

Category(s): Life sciences > Therapeutics > Manufacturing platform

Advanced nanoparticle delivery system for targeted pulmonary administration of therapeutic nucleic acids

Lipid nanoparticles (LNPs) are designed for delivering RNA to lung tissues via inhalation. Composed of ionizable lipids, phospholipids, PEG-lipids, and cholesterol, they encapsulate RNA for therapeutic or immunological purposes, maintaining stability during nebulization. Background Gene therapy and editing hold significant promise for treating genetic...

Published: 10/15/2024 | Inventor(s): Hugh Smyth, Hairui Zhang, Robert Williams

Keywords(s):

Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery

Polymer-based nanoparticle system for gene editing and therapy delivery in cystic fibrosis

The invention is a non-viral gene delivery system using PEG-bound chitosan nanoparticles to deliver CRISPR/Cas9 components, enhancing cellular uptake and stability while being biocompatible and biodegradable, to correct cystic fibrosis mutations. Background Cystic fibrosis (CF) is a genetic disorder caused by mutations in the cystic fibrosis transmembrane...

Published: 11/11/2024 | Inventor(s): Hugh Smyth, Hairui Zhang, Silvia Ferrati

Keywords(s):

Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Gene editing

Individualized intranasal delivery system for direct pharmaceutical administration to the brain

The technology involves a customizable nasal delivery device for precise administration of medications directly to the brain, bypassing traditional barriers. It uses imaging techniques for optimal placement, enhancing drug delivery efficiency and minimizing systemic side effects. Background Oral administration remains the predominant method for drug...

Published: 10/11/2024 | Inventor(s): Hugh Smyth, Robert Williams, Zachary Warnken, Yang Lu

Keywords(s):

Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Medical technology > Medical devices

Pegylated aminoglycoside compounds for enhanced treatment of biofilm infections

Pegylated aminoglycoside compounds, like m-PEG-tobramycin, combine antibiotics with polyethylene glycol to enhance solubility, stability, and bioavailability, effectively penetrating and disrupting biofilm infections resistant to standard treatments. Background Biofilm-associated infections present a significant challenge in medical and industrial...

Published: 9/16/2024 | Inventor(s): Hugh Smyth, Ju Du

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Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Agriculture > Animal/veterinary

Inhaled formulations of the NSAID indomethacin

Background Patients suffering from headache and migraine have a limited list of therapeutic options that often is shortened by issues stemming from tolerability or efficacy. For this reason, there is a big push in the industry to develop inhaled treatments for these disorders. The invention described here repurposes a compound with known efficacy...

Published: 5/8/2024 | Inventor(s): Hugh Smyth, Feng Zhang, Jamie Spahn

Keywords(s):

Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Manufacturing platform

Advancements in pulmonary antibiotic delivery: innovations for multidrug-resistant infections

Background Antibiotics like Tigecycline are vital for combating bacterial infections, but their intravenous delivery restricts usage to healthcare facilities, limiting options for patients outside such settings. The rise of multidrug-resistant respiratory infections, like those caused by S. maltophilia, necessitates innovative delivery approaches....

Published: 5/8/2024 | Inventor(s): Hugh Smyth, Varsha Nair

Keywords(s):

Category(s): Life sciences > Therapeutics > Drug delivery

Real-time breath adaptive nebulizer for optimal pulmonary drug delivery

Problem Nebulizers produce an inhalable mist for localized drug delivery and are used to treat lung diseases including COPD and cystic fibrosis. The mist produced by the nebulizer is composed of droplets of a defined size, and droplet size and velocity dictate the efficiency of nebulized drug delivery. Currently available commercial nebulizers utilize...

Published: 8/23/2024 | Inventor(s): Hugh Smyth, Matthew Herpin

Keywords(s):

Category(s): Life sciences > Therapeutics > Drug delivery

Method for dry powder inhaled delivery of clofazimine

Problem Clofazimine is highly active against a multitude of bacteria that affect the lungs; however, oral delivery of this drug is hindered by the unpredictable bioavailability and pharmacokinetics of clofazimine. Orally administered clofazimine can cause systemic toxicity, with undesirable side effects including GI complications and hyperpigmentation...

Published: 9/27/2024 | Inventor(s): Hugh Smyth, Ashlee Brunaugh

Keywords(s):

Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery

Targeted and tunable ophthalmic drug delivery

Problem Drug delivery to the eye is currently achieved by drops or less commonly, using an aerosol plume to administer the desired therapeutic. These delivery methods suffer from inaccuracies and insufficient dosage to the targeted area. Solution Dr. Smyth and his team have developed a method to deliver drugs to the eye using a tunable pulsed aerosol...

Published: 11/1/2023 | Inventor(s): Hugh Smyth, Matthew Herpin

Keywords(s):

Category(s): Life sciences > Therapeutics > Drug delivery

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