Search Results - retinal+degeneration

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Induced Pluripotent Stem Cells Derived from Patients with CEP290-associated Ciliopathies and Unaffected Family Members
Abstract: Approximately one-third of non-syndromic retinal dystrophies involve a defect in a ciliary protein. Non-syndromic retinal ciliopathies include retinitis pigmentosa, cone dystrophy, cone-rod dystrophy, macular dystrophy, and Leber-congenital amaurosis (LCA). Many CEP290-LCA patients also exhibit auditory and olfactory defects. Induced pluripotent...
Published: 4/8/2024   |   Inventor(s): Anand Swaroop, Hiroko Shimada-Ishii, Yu Holly Chen, Milton English
Keywords(s): Anosmia, Cell therapy, Ciliopathies, Congenital Blindness, Drug Development, GENE THERAPY, hearing loss, iPS, National Eye Institute, NEI, Pluripotent Stem Cells, Primary Cilia, Retina, Retinal degeneration, Swaroop, VISION
Category(s): Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat
Metformin for the Treatment of Age-related Retinal Degeneration
Abstract: Retinal Degenerations (RD) are the leading cause of blindness in the United States. The degeneration of the Retinal Pigment Epithelium (RPE) is associated with various types of RD such as Stargardt’s disease, retinitis pigmentosa, choroideremia, Late-Onset Retinal Degeneration (L-ORD), and Age-related Macular Degeneration (AMD). The RPE as...
Published: 4/8/2024   |   Inventor(s): Kapil Bharti, Kiyoharu Miyagishima, Fnu Ruchi, Justin Chang, Balendu Jha, Karla Barbosa-Sabenero, Katharina Clore-Gronenborn
Keywords(s): Age-related Macular Degeneration, AMD, Bharti, choroideremia, iPS cells, Late-Onset Retinal Degeneration, L-ORD, Metformin, RD, Retinal degeneration, Retinal Pigment Epithelium, Retinitis Pigmentosa, RPE, Stargardt’s disease
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat
Selective estrogen-receptor modulators (SERMs) confer protection against photoreceptor degeneration
Abstract: Retinal degeneration is a deteriorative condition of the human retina caused by the progressive and eventual death of photoreceptor cells. To date, no effective treatment for genetically inherited or age-associated retinal degeneration, which includes a large patient population worldwide, is available. Researchers at the National Eye Institute...
Published: 4/8/2024   |   Inventor(s): Wai Wong, Lian Zhao, Xu Wang, Wenxin Ma
Keywords(s): Age-Related Degeneration, AMD, Estrogen-receptor, Microglial Inhibition, National Eye Institute, NEI, Photoreceptor, Retinal degeneration, Retinitis Pigmentosa, RP
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, Collaboration Sought > Collaboration
Use of Interleukin (IL)-34 to Treat Retinal Inflammation and Neurodegeneration
Abstract: Interleukin (IL)-34 is a homodimer that is produced mainly by keratinocytes, neuronal cells and regulatory T cells (Tregs). It is believed to play important roles in chronic inflammation and the homeostasis of microglia. Currently, there is no effective treatment for many types of retinal degeneration. An improved treatment of autoimmune uveitis...
Published: 4/8/2024   |   Inventor(s): Rachel Caspi, Mary Mattapallil, Zhijian Wu
Keywords(s): AAV Vector, Caspi, GENE THERAPY, IL-34, inflammatory disease, Inherited Retinal Dystrophies, Interleukin 34, National Eye Institute, NEI, NEURODEGENERATION, Photoreceptor Death, Retinal degeneration, Retinal Inflammation, uveitis
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Immunology
AAV Vector that Promotes Antioxidant Production for Treatment of Age-Related Macular Degeneration
Gene Therapy Requires Just One Intraocular Injection to Treat Eye Ailment Caused by Oxidative StressThis AAV gene therapy approach provides a one-time treatment to oxidative stress. Sustained oxidative stress can lead to a variety of pathophysiological diseases including age-related macular degeneration, diabetic retinopathy, and amyotrophic lateral...
Published: 12/22/2022   |   Inventor(s): Qiuhong Li, Christhian Ildefonso, Alfred Lewin
Keywords(s): Age Related Macular Degeneration, Alzheimer's Disease, Diabetic Retinopathy, Gene Therapy, Macular Degeneration, Retinal Degeneration, uveitis
Category(s): Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Others
Drug Delivery System for Extended Release of Retinal Drugs
Prolongs Delivery and Release of Drugs for Treating Retinal DiseasesThis drug delivery system delivers ophthalmic drugs that release to the retina over an extended period of time to treat retinal diseases. Diseases of the retina are one of the leading causes of vision loss and cost an estimated $343 billion globally. However, the challenge lies in facilitating...
Published: 6/27/2021   |   Inventor(s): Anuj Chauhan, Russell Macoon
Keywords(s): Device, Drug Delivery (controlled), intravitreal, Medical, Retina, Retinal Degeneration
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Medical Devices > Consumable