Search Results - nicholas+muzyczka

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Resting-State Functional Magnetic Resonance Imaging Derived From Dynamic Perfusion Imaging (Case No. 2023-126)
Intro Sentence: UCLA researchers in the Department of Radiology have developed a novel method for obtaining simultaneous perfusion and functional MRI data from a single MRI acquisition to improve the diagnosis, monitoring, and management of brain tumors and stroke. Background: Advanced magnetic resonance imaging (MRI) techniques are crucial for...
Published: 10/23/2024   |   Inventor(s): Benjamin Ellingson, Nicholas Cho, Chencai Wang
Keywords(s):  
Category(s): Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Medical Devices > Monitoring And Recording Systems
Capsid Mutation System for Producing Recombinant AAV2 Vectors With Lower Affinity to Herapin Sulfate
Produces Recombinant AAV2 vectors with Higher Target SpecificityThis system for generating AAV2, or recombinant Adeno Associated Virus stereotype 2, lowers the presence of herapin sulfate receptor sites by mutating viral capsid proteins. Recent developments in gene therapy have shown great potential of recombinant AAV2 as a vector, due to its low immunogenicity...
Published: 6/27/2021   |   Inventor(s): Shaun Opie, Kenneth Warrington, Nicholas Muzyczka
Keywords(s): Gene Therapy, Genetic Therapy
Category(s): Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Others
Receptor-Ligand Combination for Specific Drug Delivery to the Brain
Molecule Crosses the Blood-Cerebrospinal Fluid Barrier to Deliver Therapy into Targeted CellsThis engineered receptor-ligand combination targets and crosses the brain barriers of mammals to deliver drugs and therapeutics to the brain. About 12 percent of all deaths worldwide are caused by neurological disorders such as Alzheimer’s, Parkinson’s...
Published: 12/20/2021   |   Inventor(s): Hector Mendez-Gomez, Nicholas Muzyczka
Keywords(s): Blood-brain barrier, brain delivery, brain-specific drug delivery, Gene Therapy, receptor-mediated transcytosis
Category(s): Technology Classifications > Human Health Care > Drug Delivery, Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Research Tools > Therapeutics