Search Results - als

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Glial Cell Line-Derived Neurotrophic Factor for the Treatment of Neurodegenerative Diseases and Diabetes
Abstract: The National Institute on Drug Abuse (NIDA) is seeking interested parties to license or co-develop GDNFOS peptides and non-coding RNAs as therapeutic agents for neurodegenerative diseases. Glial cell line-derived neurotrophic factor (GDNF) is a small human protein encoded by the GDNF gene. GDNF has been effective therapy in laboratory animal...
Published: 4/8/2024   |   Inventor(s): Qing Rong Liu
Keywords(s): ALS, GDNFOS3., Glial Cell Line Derived Neurotrophic Factor (GDNF), Multiple sclerosis, Parkinson's Disease
Category(s): TherapeuticArea > Neurology, Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration
Drug Candidate for ALS
RNA aptamers that focus on glutamate receptors are a potential drug candidate for amyotrophic lateral sclerosis (ALS). Background: Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, is a progressive neuromuscular disease for which there is no cure. The disease attacks motor neurons that run from the brain to the spinal cord...
Published: 1/29/2024   |   Inventor(s): Li Niu, Zhen Huang
Keywords(s): ALS, amyotrophic lateral sclerosis, aptamers, drug design, Lou Gehrig's disease, MND, motor neurone disease, RNA
Category(s): Technology Classifications > Biomedical Science and Engineering, Campus > University at Albany
Novel Compounds in Treating Autophagy-Related Pathologies
Project IDs: D2015-09 and D2016-81 Background: Autophagy is a self-degradation process of cellular organelles that helps defend against metabolic stress, maintain metabolic equilibrium, arbitrate cell fate decisions, and safeguard genomic stability. Deficient autophagy has been associated with over 100 diseases, and experimental enhancement of autophagy...
Published: 5/9/2024   |   Inventor(s): Kenneth Hensley, Travis Denton
Keywords(s): ALS, Alzheimer's, Autophagy, Lanthionine Ketimine, Parkinson's
Category(s): Neuroscience
A Method to Treat Alzheimer’s, Heart and Liver Diseases
Technology Description This technology describes a process for the preparation of the tripeptide glutathione or its precursors to be delivered to the mitochondria for treating age-related conditions, toxicologic exposures, neurodegeneration, heart disease, and liver damage. More specifically, glutathione precursors and derivatives are coupled to a lipophilic...
Published: 5/26/2021   |   Inventor(s): Tory Hagen, Joseph Beckman, Pamela Beilby
Keywords(s): ALS, Alzheimer's, Antioxidant, Cancer, Liver disease, Medical Science & Technologies, Mitochondria, Neurodegenerative disease
Category(s): Biological Materials, Chemical, Diagnostics, Research Tools, Therapeutics
Use of fluorescent ANTS to examine the BBB-permeability of polysaccharide
Project ID: D2015-27Invention Description: Methods of generating and administering digestion products of FDA-approved low acyl gellan gum (LA-GAGR) to produce neuroprotective mega-GAGR, midi-GAGR, and mini-GAGR and administration thereof.Applications: Compositions comprising midi and/or mini-GAGR have been shown to be useful for treatment of neurodegenerative...
Published: 8/3/2022   |   Inventor(s): Joshua Park, Kevin Christopher, Vishruti Makani
Keywords(s): ALS, Alzheimer’s disease, Blood-brain Barrier, Brain Trauma, Neuritogenesis, Neurodegenerative, Neuroprotective, Spinal Cord Injury
Category(s):  
Novel agents and methods for treating neurodegenerative disorders
Project ID: D2013-69 IP Status: Issued Patents 10,792,301 B2, 11,197,885 B2 Invention Description: Methods of generating and administering digestion products of FDA-approved low acyl gellan gum (LA-GAGR) to produce neuroprotective mega-GAGR, midi-GAGR, and mini-GAGR and administration thereof. Applications: Compositions comprising midi and/or mini-GAGR...
Published: 8/7/2024   |   Inventor(s): Joshua Park, Dong Shik Kim, Kenneth Hensley
Keywords(s): ALS, Alzheimer’s disease, Blood-brain Barrier, Brain Trauma, Neuritogenesis, Neurodegenerative, Neuroprotective, Spinal, Spinal Cord Injury
Category(s): Neuroscience