Search Results - neuroscience

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Methods and considerations for estimating parameters in biophysically detailed neural models with simulation based inference
Methods and considerations for estimating parameters in biophysically detailed neural models with simulation based inference Overview Biophysically detailed neural models are powerful tools for bridging scales in neuroscience, linking cellular and circuit-level mechanisms to macro-scale signals like EEG/MEG. These models incorporate ion channels,...
Published: 5/28/2025   |   Inventor(s): Stephanie Jones, Nicholas Tolley
Keywords(s):  
Category(s): Neuroscience
Process and method for novel biomarker discovery using electromagnetic beta signal waveforms for prediction and diagnosis of neurological disorders and brain states
Dissecting beta waveforms using convolutional dictionary learning across sensory perception, aging, and disease OVERVIEW This technology is a system and method for analyzing brain wave patterns, specifically beta waves (13-30 Hz), to identify biomarkers that can predict neurological conditions and brain states. The technology leverages advanced signal...
Published: 5/22/2025   |   Inventor(s): Stephanie Jones, David Zhou
Keywords(s):  
Category(s): Aging, Neurodegenerative Disease, Neuroscience
Dopamine (DA) control of blood-brain barrier (BBB) permeability
Transient blood-brain barrier opening via brain subsystem stimulation Overview One of the primary obstacles of delivering pharmacological agents to the brain is the blood-brain barrier (BBB). This technology describes methods for selectively opening the BBB by stimulating dopaminergic neurons in specific areas of the midbrain, particularly the ventral...
Published: 5/22/2025   |   Inventor(s): Christopher Moore, Sinda Fekir
Keywords(s):  
Category(s): Neuroscience, Neurotechnology, Central Nervous System(CNS), Drug Delivery
SUBCUTANEOUS MULTICHANNEL WIRELESS EEG FOR CHRONIC HOME USE
Subcutaneous Multi-Channel Wireless EEG For Continuous Home Monitoring Overview It is increasingly recognized that for many patients, like those with epilepsy, it can be of paramount importance to record neural activity continuously, 24/7, over weeks and months. Yet, no clinically viable system exists. Currently, the principal diagnostic method for...
Published: 5/22/2025   |   Inventor(s): Arto Nurmikko, Farah Laiwalla, Jihun Lee, Ah-Hyoung Lee, Sydney Cash
Keywords(s):  
Category(s): Devices, Neurotechnology, Neuroscience
Allosteric Modulation of Muscarinic Acetylcholine Receptor for Treatment of Neurological Disorders
Project ID: D2022-18 Background Muscarinic acetylcholine receptors (mAChRs) are G protein-coupled receptors that are located in the cell membranes of neurons and mediate the effects of the neurotransmitter acetylcholine (ACh). Each mAChR forms a complex with intracellular G proteins that, when activated, produce an intracellular signaling cascade....
Published: 8/23/2024   |   Inventor(s): William Messer, Hazel Cunningham, Corey Widman, John Ellis, Isaac Schiefer, Gina Kaup
Keywords(s):  
Category(s): Neuroscience
Bore Embolization Catheter
Project ID: D2021-45 Background: With increasing use of embolization in minimally invasive surgical procedures, the demand for microcatheters has increased exponentially and the growth rate is at 8%. Arteriovenous malformations (AVMs) are abnormal connections between arteries and veins in the brain or spine. The distinguishing feature of an AVM is...
Published: 3/6/2025   |   Inventor(s): Syed Zaidi, Mouhammad Jumaa
Keywords(s):  
Category(s): Neuroscience, Medical Device
Compounds for non-lethal micropinocytosis and exosome production
Project ID: D2017-25 Background Exosomes are vesicles in the range of 30 to 120nm, which are released from mammalian cells when multi-vesicular endosomes fuse with the plasma membrane. In recent times, exosomes have been implicated in cancer. Mounting evidence suggests that exosomes play an important role in mediating intercellular communication...
Published: 6/18/2024   |   Inventor(s): William Maltese, Paul Erhardt, Zehui (Lesley) Li, Christopher Trabbic
Keywords(s): Cancer, Exosome, Vacuole, Vesicle
Category(s): Neuroscience, Oncology, Diagnostics
Compounds for disrupting microtubule networks and mitosis in brain cancer
Project ID: D2014-42 Background Primary brain tumors and secondary intracranial tumors from metastatic spread of other cancers (e.g., melanoma, lung carcinoma) have been inaccessible to therapy with microtubule-targeted agents (vincristine, vinblastine, paclitaxel) because the latter do not readily cross the blood-brain barrier. Invention...
Published: 6/18/2024   |   Inventor(s): William Maltese, Paul Erhardt, Christopher Trabbic, Jean Overmeyer
Keywords(s):  
Category(s): Neuroscience, Oncology
Implantable Wireless Network of Distributed Microscale Sensors for Neural Applications
­Wireless Network of Neural Implants for Brain-Machine Interfaces Overview The field of brain-machine interfaces has advanced significantly over the past two decades, especially in its successful transition into human clinical trials. This progress has relied largely on wired, invasive sensors for the acquisition of neural data with high spatial...
Published: 3/5/2025   |   Inventor(s): Arto Nurmikko, Farah Laiwalla, Lawrence Larson, Jihun Lee, Patrick Mercier, Peter Asbeck, Vincent Leung
Keywords(s):  
Category(s): Neuroscience
Adaptive, Wireless Microchiplet Network for Large Scale Cortical Sensing and Stimulation
Wireless Network of Neural Implants for Brain-Machine Interfaces Overview The field of brain-machine interfaces has advanced significantly over the past two decades, especially in its successful transition into human clinical trials. This progress has relied largely on wired, invasive sensors for the acquisition of neural data with high spatial and...
Published: 3/5/2025   |   Inventor(s): Arto Nurmikko, Lawrence Larson, Farah Laiwalla, Peter Asbeck, Ramesh Rao, Vincent Leung, Patrick Mercier, Jihun Lee
Keywords(s):  
Category(s): Neuroscience
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