Search Results - neuroscience

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SUBCUTANEOUS MULTICHANNEL WIRELESS EEG FOR CHRONIC HOME USE
Subcutaneous Multi-Channel Wireless EEG For Continuous Home Monitoring Overview It is increasingly recognized that for many patients, like those with epilepsy, it can be of paramount importance to record neural activity continuously, 24/7, over weeks and months. Yet, no clinically viable system exists. Currently, the principal diagnostic method for...
Published: 12/20/2024   |   Inventor(s): Arto Nurmikko, Farah Laiwalla, Jihun Lee, Ah-Hyoung Lee, Sydney Cash
Keywords(s):  
Category(s): Devices, Neurotechnology, Neuroscience
Allosteric Modulation of Muscarinic Acetylcholine Receptor for Treatment of Neurological Disorders
Project ID: D2022-18 Background Muscarinic acetylcholine receptors (mAChRs) are G protein-coupled receptors that are located in the cell membranes of neurons and mediate the effects of the neurotransmitter acetylcholine (ACh). Each mAChR forms a complex with intracellular G proteins that, when activated, produce an intracellular signaling cascade....
Published: 8/23/2024   |   Inventor(s): William Messer, Hazel Cunningham, Corey Widman, John Ellis, Isaac Schiefer, Gina Kaup
Keywords(s):  
Category(s): Neuroscience
Bore Embolization Catheter
Project ID: D2021-45 Background: With increasing use of embolization in minimally invasive surgical procedures, the demand for microcatheters has increased exponentially and the growth rate is at 8%. Arteriovenous malformations (AVMs) are abnormal connections between arteries and veins in the brain or spine. The distinguishing feature of an AVM is...
Published: 10/29/2024   |   Inventor(s): Syed Zaidi, Mouhammad Jumaa
Keywords(s):  
Category(s): Neuroscience, Medical Device
Compounds for non-lethal micropinocytosis and exosome production
Project ID: D2017-25 Background Exosomes are vesicles in the range of 30 to 120nm, which are released from mammalian cells when multi-vesicular endosomes fuse with the plasma membrane. In recent times, exosomes have been implicated in cancer. Mounting evidence suggests that exosomes play an important role in mediating intercellular communication...
Published: 6/18/2024   |   Inventor(s): William Maltese, Paul Erhardt, Zehui (Lesley) Li, Christopher Trabbic
Keywords(s): Cancer, Exosome, Vacuole, Vesicle
Category(s): Neuroscience, Oncology, Diagnostics
Compounds for disrupting microtubule networks and mitosis in brain cancer
Project ID: D2014-42 Background Primary brain tumors and secondary intracranial tumors from metastatic spread of other cancers (e.g., melanoma, lung carcinoma) have been inaccessible to therapy with microtubule-targeted agents (vincristine, vinblastine, paclitaxel) because the latter do not readily cross the blood-brain barrier. Invention...
Published: 6/18/2024   |   Inventor(s): William Maltese, Paul Erhardt, Christopher Trabbic, Jean Overmeyer
Keywords(s):  
Category(s): Neuroscience, Oncology
Implantable Wireless Network of Distributed Microscale Sensors for Neural Applications
­Wireless Network of Neural Implants for Brain-Machine Interfaces Overview The field of brain-machine interfaces has advanced significantly over the past two decades, especially in its successful transition into human clinical trials. This progress has relied largely on wired, invasive sensors for the acquisition of neural data with high spatial...
Published: 12/19/2024   |   Inventor(s): Arto Nurmikko, Farah Laiwalla, Lawrence Larson, Jihun Lee, Patrick Mercier, Peter Asbeck, Vincent Leung
Keywords(s):  
Category(s): Neuroscience
Adaptive, Wireless Microchiplet Network for Large Scale Cortical Sensing and Stimulation
Wireless Network of Neural Implants for Brain-Machine Interfaces Overview The field of brain-machine interfaces has advanced significantly over the past two decades, especially in its successful transition into human clinical trials. This progress has relied largely on wired, invasive sensors for the acquisition of neural data with high spatial and...
Published: 12/19/2024   |   Inventor(s): Arto Nurmikko, Lawrence Larson, Farah Laiwalla, Peter Asbeck, Ramesh Rao, Vincent Leung, Patrick Mercier, Jihun Lee
Keywords(s):  
Category(s): Neuroscience
Peel-Away Electrode Placement Catheter for Deep Brain Stimulation (DBS)
­Brown’s Laboratory for Neurophysiology and Neuromodulation The Laboratory for Neurophysiology and Neuromodulation studies neural circuits in humans and nonhuman animal models to understand action planning, learning, and high-level cognition, to place neurological and psychiatric dysfunction into these mechanistic contexts, and to design...
Published: 12/18/2024   |   Inventor(s): Wael Asaad, Shane Lee, Owen Leary, Noah Trac, Zakir Tahiry, Rohan Rastogi
Keywords(s):  
Category(s): Central Nervous System(CNS), Devices, Neuroscience
Continuous motor task for objectively quantifying motor symptoms in movement disorders
­Brown’s Laboratory for Neurophysiology and Neuromodulation The Laboratory for Neurophysiology and Neuromodulation studies neural circuits in humans and nonhuman animal models to understand action planning, learning, and high-level cognition, to place neurological and psychiatric dysfunction into these mechanistic contexts, and to design...
Published: 12/18/2024   |   Inventor(s): Wael Asaad, Shane Lee, Minkyu Ahn, James Yu, Daniel Amaya, David Liu, Peter Lauro
Keywords(s):  
Category(s): Central Nervous System(CNS), Neuroscience, Devices
Novel Compounds for Treatment of Neurodegenerative Conditions and Diseases (Case 1939)
Novel Compounds for Treatment of Neurodegenerative Conditions and Diseases Overview Stroke and other neurological insults entail a build-up of waste materials in brain cells. One of the most common waste materials is glutamate, which is present in more than 50 percent of nervous tissue. Glutamate receptors are critical to neuronal functioning. Failure...
Published: 4/28/2022   |   Inventor(s): John Marshall, Mark Spaller, Dennis Goebel
Keywords(s):  
Category(s): Neuroscience, Research Tools, Therapeutics
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