Search Results - neurological+disorders

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A Tissue-Like Multimodal Neural Probe (Case No. 2024-108)
Summary: UCLA researchers in the Department of Materials Science and Engineering have developed a novel self-softening and biocompatible polymer to be used in a neural probe. Background: Implantable bioelectronics are revolutionizing the diagnosis and treatment of neurological and neuropsychiatric disorders. Compared with noninvasive approaches,...
Published: 9/20/2024   |   Inventor(s): Anne Andrews, Qibing Pei, Zhixin Xie, Chuanzhen Zhao
Keywords(s): bioelectronics, neural stimulation, Neuroimaging, Neurointervention, neurological disorders, Neuromodulation, Neuropsychological Test, Polymer, Smart Material, soft robotics, thermal stability, Tissue (Biology)
Category(s): Chemical, Chemical > Polymers, Medical Devices > Neural Stimulation, Therapeutics > CNS and Neurology, Materials > Nanotechnology
Intelligent Stent System for Chronic On-Demand Drug Delivery (Case No. 2021-069)
Summary: UCLA researchers in the Department of Neurology have developed an intelligent stent system for chronic on-demand drug delivery, addressing the challenge of the blood-brain barrier hindering drug therapy in the central nervous system. Background: The blood-brain barrier poses a significant obstacle to effective drug delivery to the central...
Published: 7/9/2024   |   Inventor(s): Jose Morales, Haotian Lu, Huachen Cui, Xiaoyu (Rayne) Zheng
Keywords(s): blood flow management, blood-brain barrier, Drug, Drug Delivery, Drug monitoring, Invasiveness Of Surgical Procedures, MEMS, minimally invasive device, minimally invasive drug delivery systems, neural signals, neural stimulation, Neurocognitive, Neurodegeneration, neurological disorders, Neurology, neuro-oncology, Neuropathology, Neurosurgery, non-invasive, non-invasive drug monitoring, on-demand drug delivery, Pharmaceutical Drug, piezoelectric ultrasound transducers
Category(s): Platforms, Platforms > Drug Delivery, Medical Devices, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Oncology, Therapeutics > Musculoskeletal Disease
Alkylaminoquinones as Multifunctional Radical Quenchers
Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energetic defects have been implicated in forms of movement disorders, cardiomyopathy,...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Manikandadas Mathilakathu Madathil, Omar Khdour
Keywords(s): Alzheimer's Disease, CNS Therapeutics, Drug, Mitochondrial medicine, Neurodegenerative Disorders, Neurological Disorders, Pharmaceutical, Therapeutics
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals
A System for Detecting Ventriculoperitoneal Shunt Failure (Case No. 2023-057)
Summary: UCLA researchers in the David Geffen School of Medicine and Department of Neurosurgery have created a novel ventriculoperitoneal shunt failure detection system that can alert patients and healthcare providers to prevent life-threatening emergencies. Background: Each year, an estimated 30,000 ventriculoperitoneal (VP) shunts are surgically...
Published: 12/19/2023   |   Inventor(s): Geoffrey Colby, David Zarrin
Keywords(s): catheter, cerebrospinal fluid (CSF), CSF disorders, early alert system, elevated intracranial pressure, extraventricular drain, hydrocephalus, intracranial hypertension, intracranial pressure, neurological disorders, ventricular system, ventriculoperitoneal, ventriculoperitoneal shunt failure
Category(s): Medical Devices, Medical Devices > Surgical Tools, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Electrical, Electrical > Sensors, Electrical > Instrumentation
Size-dependent brain distribution of macromolecular drug delivery platform
Abstract: The blood brain barrier (BBB) is a specialized endothelium that prevents the uptake of substances from the systemic circulation into the central nervous system. This barrier, while protecting the sensitive physiological environment of the brain, is also a major impediment in administering therapeutics that need to pass through the BBB. A drug...
Published: 4/8/2024   |   Inventor(s): Stephan Stern, David Stevens
Keywords(s): BBB, Blood-brain Barrier, Brain Cancer, Controlled Drug Release, Drug Delivery Platform, Neurological Disorders, Stern
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Neurology
Novel hasubanan-based analgesics
There are three main medication alternatives for use in treating opioid addiction; methadone, buprenorphine, and naltrexone which can be used separately or in combination (e.g., buprenorphine and naltrexone). All three medications are FDA approved and can reduce opioid cravings helping to sever the ties between opioid use and situational/emotional triggers....
Published: 2/5/2024   |   Inventor(s): Thomas Keck, Gustavo Moura-Letts
Keywords(s): Addiction, Neurological disorders, Therapeutic
Category(s): Human Health Care > Therapeutics
Neuron Foundry
More than a billion people worldwide suffer from some form of a neurological disorder such as Alzheimer's (AD), Parkinson's (PD), multiple sclerosis, epilepsy, stroke, or autism. These conditions result in more than 7 million deaths, with associated costs exceeding $1.5 trillion per year. PD is a neurodegenerative disease that causes severe...
Published: 2/12/2024   |   Inventor(s): Charles McGlynn
Keywords(s): Light Energy, Microwave, Neurological disorders, Therapeutic
Category(s): Engineering, Human Health Care > Therapeutics