Search Results - glioblastoma

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Compounds and Methods for Treating Cancer by Destroying Cancer Stem Cells (UCLA Case No. 2021-286)
Researchers from UCLA’s Department of Chemistry and Biochemistry and the Department of Radiation Oncology have synthesized a set of compounds for the eradication of cancer stem cells. These compounds are predicted to cross the blood brain barrier and show promise as effective interventions for glioblastoma in both in vitro and in vivo assays. BACKGROUND:...
Published: 7/11/2024   |   Inventor(s): Michael Jung, Frank Pajonk
Keywords(s): blood-brain barrier, Brain, Cancer, Cancer stem cells, drug screening, GBM, Glioblastoma, Glioma, new chemical entity
Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology, Therapeutics > Stem Cells And Regenerative Medicine
Human Glioblastoma Model (UCLA Case No. 2023-273/2024-151)
UCLA researchers in the Department of Biological Chemistry have developed a novel method to study glioblastoma using human brain organoids. BACKGROUND: The National Institutes of Health defines glioblastoma as the most malignant and pervasive subtype of glioma, or glial-based cancer, and report that it is the most common primary brain tumor in adults....
Published: 6/18/2024   |   Inventor(s): Aparna Bhaduri
Keywords(s): Brain cancer, Brain organoid, Brain Tumor, Cancer, Glioblastoma, Organoids
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Oncology
Synthetic Lethality of IR with ABBV-155 in Glioblastoma (GBM) (UCLA Case No. 2021-232)
UCLA researchers in the Department of Molecular and Medical Pharmacology have discovered that irradiation therapy can be combined with an antibody drug conjugate to form a novel therapeutic strategy to treat and extend survival of glioblastoma patients. BACKGROUND: Glioblastoma (GBM) is a fast-growing and aggressive brain tumor. The National Brain...
Published: 8/28/2024   |   Inventor(s): David Nathanson
Keywords(s): Antibody-Drug Conjugate, Apoptosis, Brain cancer, Cancer, Glioblastoma, irradiation
Category(s): Therapeutics > Oncology
Integrated Molecular and Lipidomic Analysis of Glioma Tumors Identifies Therapeutic Vulnerabilites (UCLA Case No. 2023-210)
UCLA researchers in the Department of Molecular and Medical Pharmacology have uncovered a novel therapeutic target for Glioblastoma leveraging an extensive lipidomic and transcriptomic database. BACKGROUND: Glioblastoma (GBM) is a fast-growing and aggressive brain tumor. The National Brain Tumor Society predicted that over 14,000 people in the United...
Published: 5/14/2024   |   Inventor(s): David Nathanson
Keywords(s): Brain cancer, Brain Tumor, cancer target, cell death, ferroptosis, Glioblastoma, lipidomics
Category(s): Therapeutics > Oncology
Targeting the Intrinsic Apoptotic Machinery in Glioblastoma Multiforme (GBM) (UCLA Case No. 2020-446)
UCLA researchers in the Department of Molecular and Medical Pharmacology identified the mechanisms of apoptotic resistance in glioblastoma multiforme (GBM) and developed a novel therapy to treat GBM. BACKGROUND: Glioblastoma (GBM) is the most aggressive form of brain tumor. Therapeutic options for GBM are limited and suboptimal. Treatment usually...
Published: 2/16/2024   |   Inventor(s): David Nathanson
Keywords(s): anti-apoptotic inhibitor, Anti-apoptotic pathway, Apoptosis, Brain Tumor, Glioblastoma, irradiation, p53, temozolomide
Category(s): Therapeutics > Oncology
The preparation of a brain targeted artificial nano-enzyme and application
Reference #: 01514 The University of South Carolina is offering licensing opportunities for The preparation of a brain targeted artificial nano-enzyme and application Background: Chronic neuroinflammation is caused by the activation of microglia, which is the major cause of central neuronal system (CNS) diseases, including Alzheimer’s disease,...
Published: 4/25/2024   |   Inventor(s): Peisheng Xu, Haijun Liu
Keywords(s): Alzheimer’s disease, Amyotrophic lateral sclerosis, brain injury, Brain targeted nanoparticle, Brain tumor, Epilepsy, frontotemporal dementia, glioblastoma, Huntington's disease, Multiple sclerosis, neonatal hypoxic-ischemic, neuroblastoma, Parkinson's disease, post-traumatic stress disorder, Spinal cord injury, stroke
Category(s): Nanotechnology, Health Sciences, Biomedical and Life Sciences
Targeting mDia formins to halt tumor microtube formation, invasion, and proliferation in brain tumors
Project ID D2019-34 Background Tumor therapies must overcome complex obstacles, such as cellular invasion, chemoresistance, and radioresistance. Cells within a brain tumor often form specialized ultralong cellular projections called tumor microtube (TM) projections that allow them to invade new areas of the brain. The networks formed by TMs interconnect...
Published: 6/18/2024   |   Inventor(s): Kathryn Eisenmann, Krista Pettee, Kathryn Becker
Keywords(s): Tumor microtubes, Cancer, Formin, Glioblastoma, High-grade glioma, Invasion, mDia
Category(s): Oncology, Neuroscience
GENE THERAPY FOR IMMUNO-ONCOLOGY APPLICATIONS
GENE THERAPY FOR IMMUNO-ONCOLOGY APPLICATIONS Researchers at the Chan Zuckerberg Biohub and UCSF have developed viral gene therapy delivery systems for therapeutic immuno-oncology applications. Glioblastoma is the most common and deadliest primary malignant brain cancer with an overall median survival of 14.6 months. Therapies currently in use, and...
Published: 5/31/2023   |   Inventor(s): Nicole Paulk, Joseph DeRisi, David Raleigh
Keywords(s): Convection Enhanced Delivery, Gene Therapy, Glioblastoma, Immuno-Oncology, Interferon (IFN), Recombinant Adenoviral-Associated Virus (rAAV)
Category(s): Technology Classifications > Biology
Glioblastoma Stem Cell Regulators with Therapeutic Potential
Targets Crucial Cancer Stem Cell Factors to Inhibit Glioblastoma Growth This combination of cancer master regulators enables targeting glioblastoma (GBM) stem cells to inhibit their growth. According to the National Brain Tumor Society, only 5.5 percent of patients suffering from GBM survive five or more years after diagnosis, due to rapid cell growth...
Published: 6/27/2021   |   Inventor(s): David Tran, Son Le
Keywords(s): cancer drug targets, GBM, GBM stem cells, Glioblastoma, master regulators, stemness
Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Human Health Care > Therapeutics