Search Results - neurodegeneration

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Intelligent Stent System for Chronic On-Demand Drug Delivery (Case No. 2021-069)
Summary: UCLA researchers in the Department of Neurology have developed an intelligent stent system for chronic on-demand drug delivery, addressing the challenge of the blood-brain barrier hindering drug therapy in the central nervous system. Background: The blood-brain barrier poses a significant obstacle to effective drug delivery to the central...
Published: 7/9/2024   |   Inventor(s): Jose Morales, Haotian Lu, Huachen Cui, Xiaoyu (Rayne) Zheng
Keywords(s): blood flow management, blood-brain barrier, Drug, Drug Delivery, Drug monitoring, Invasiveness Of Surgical Procedures, MEMS, minimally invasive device, minimally invasive drug delivery systems, neural signals, neural stimulation, Neurocognitive, Neurodegeneration, neurological disorders, Neurology, neuro-oncology, Neuropathology, Neurosurgery, non-invasive, non-invasive drug monitoring, on-demand drug delivery, Pharmaceutical Drug, piezoelectric ultrasound transducers
Category(s): Platforms, Platforms > Drug Delivery, Medical Devices, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Oncology, Therapeutics > Musculoskeletal Disease
Use of Neurotrophic Factor-alpha1/Carboxypeptidase E (CPE) to Treat Alzheimer Disease
Abstract: There is no known cure for Alzheimer’s disease, a brain disorder that severely affects memory, thinking, learning, and organizing skills. It eventually decreases a person’s ability to carry out simple, daily activities. It is predicted that over 14 million Americans will develop Alzheimer’s without effective treatment options. Mild cognitive...
Published: 4/8/2024   |   Inventor(s): Yoke Loh, Yong Cheng
Keywords(s): “Cognitive impairment”, Ad, Alzheimer’s Disease, BNDF, brain, Brain-Derived Neurotrophic Factor, Carboxypeptidase E, CPE, Hippocampus, LOH, MCI, MEMORY, Mild Cognitive Impairment, NEURODEGENERATION, NEUROTROPHIC
Category(s): TherapeuticArea > Neurology, Application > Therapeutics, Collaboration Sought > Licensing
Use of Interleukin (IL)-34 to Treat Retinal Inflammation and Neurodegeneration
Abstract: Interleukin (IL)-34 is a homodimer that is produced mainly by keratinocytes, neuronal cells and regulatory T cells (Tregs). It is believed to play important roles in chronic inflammation and the homeostasis of microglia. Currently, there is no effective treatment for many types of retinal degeneration. An improved treatment of autoimmune uveitis...
Published: 4/8/2024   |   Inventor(s): Rachel Caspi, Mary Mattapallil, Zhijian Wu
Keywords(s): AAV Vector, Caspi, GENE THERAPY, IL-34, inflammatory disease, Inherited Retinal Dystrophies, Interleukin 34, National Eye Institute, NEI, NEURODEGENERATION, Photoreceptor Death, Retinal degeneration, Retinal Inflammation, uveitis
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Immunology
2021-278 Enhancement of Human Memory and Treatment of Alzheimer’s Disease by Closed -Loop Phase-Locked Brain Electric Stimulation During Sleep
­SUMMARY: UCLA researchers in the department of Neurosurgery have developed an implantable brain electrode system which can modulate the brain’s activity to improve sleep and consolidation of memory, several important activities in the treatment of Alzheimer’s Disease. BACKGROUND: Sleep is universally understood to be beneficial to...
Published: 7/19/2023   |   Inventor(s): Itzhak Fried, Yuval Nir, Maya Geva-Sagiv
Keywords(s): Deep Brain Stimulation, Deep Brain Stimulation Current Mirror Output Impedance, Electrical Brain Stimulation, Memory, Neurocognitive, Neurodegeneration, Neurodegeneration Alzheimer's Disease Predictive Testing, Neuromodulation, Neurostimulation
Category(s): Medical Devices > Neural Stimulation, Medical Devices > Monitoring And Recording Systems
Neuropsychological digital assessment test that identifies discrete latencies in response time to identify emergent neurological/nueropsychiatric illness
TechnologyDeclining cognitive health is increasing in the U.S and worldwide. Early detection of impairment is crucial to altering the course of disease. Many cognitive assessments have previously focused on early memory defects, such as those associated with Alzheimer’s, and it is now evident that focused deficits accumulate over several decades...
Published: 3/6/2024   |   Inventor(s): David Libon, Ganesh Baliga, Mary Kerwin, Rod Swenson
Keywords(s): Alzheimer's, Assesments, Cognition, Dementia, Intervention, Neurodegeneration, Quantitative
Category(s): Research Tools, Software, Human Health Care > Biomarkers, Diagnosis and Detection