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16950
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Title
ID
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Qui
n
oline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
A lead compou
n
d, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025
|
Inventor(s):
Ju
n
Wang
,
Prakash Jadhav
,
Bi
n
Tan
,
Haozhou Ta
n
Keywords(s):
A
n
tiviral
Category(s):
Tech
n
ology Classifications > COVID-19
,
Tech
n
ology Classifications > Healthcare & Life Sciences
,
Tech
n
ology Classifications > Infectious Disease
,
Tech
n
ology Classifications > Therapeutics
Specific i
n
hibitors to mitigate mu opioid‐induced side‐effects without compromising analgesia
Prelimi
n
ary data shows that the inhibitor significantly mitigates morphine tolerance in a mouse study Invention Summary: Mu opioids such as morphine and fentanyl are commonly used for pain management but can lead to tolerance, addiction, and opioid use disorder. Current therapeutic solutions for these adverse conditions include buprenorphine,...
Published: 7/31/2025
|
Inventor(s):
Yi
n
gxian Pan
Keywords(s):
Category(s):
Tech
n
ology Classifications > Healthcare & Life Sciences
,
Tech
n
ology Classifications
,
Tech
n
ology Classifications > Therapeutics
Method for Optimizi
n
g an Integrated Flight Control System using Reinforcement Meta-Learning
This tech
n
ology is a method to incorporate reinforcement meta-learning to the design of a flight control system for missiles. The integration will benefit the control system, as it optimizes it with the help of a simulation environment. The technology removes the need for manual tuning of the control system settings. Background: The flight control...
Published: 7/30/2025
|
Inventor(s):
Roberto Furfaro
,
Bria
n
Gaudet
Keywords(s):
Category(s):
Tech
n
ology Classifications > Software & Information Technology
,
Tech
n
ology Classifications > Engineering & Physical Sciences > Aerospace Engineering
TRP: A Mouse Model of Limb Girdle Muscular Dystrophy Type 2A (R1/D4) (UCLA Case
N
o. 2021-171)
UCLA researchers i
n
the Department of Neurology have developed a novel mouse model for limb girdle muscular dystrophy, a disorder that causes muscle weakness in the limbs and hip area. BACKGROUND: Limb-Girdle Muscular Dystrophy Type 2A (LGMDR1) is a genetic neuromuscular disorder characterized by progressive muscle weakness, primarily affecting muscles...
Published: 7/30/2025
|
Inventor(s):
Melissa Spe
n
cer
Keywords(s):
Category(s):
Life Scie
n
ce Research Tools > Animal Models
Regioselective 1,2-Dearomatizatio
n
of Functionalized Azines by Organolanthanide Catalysts
N
U2014-129 INVENTORS Tobin Marks* Alexander Dudnik Massimiliano Delferro Victoria Weidner SHORT DESCRIPTION This invention describes a catalytic process for the regioselective 1,2-dearomatization of functionalized azines using an organolanthanide catalyst and pinacolborane (HBpin). It offers a streamlined approach to key intermediates for pharmaceuticals...
Published: 7/30/2025
|
Inventor(s):
Keywords(s):
Catalyst
,
Chemicals
,
Ma
n
ufacturing/Processing
,
Materials
Category(s):
Physical Scie
n
ces > Materials and Industrial Processes
N
ovel self-healing commodity copolymers based on 2-ethylhexyl acrylate
N
U2023-240 INVENTORS John Torkelson* Tong Wang SHORT DESCRIPTION This invention describes a new class of random copolymers that exhibit autonomous self-healing behavior at room temperature. The copolymers, derived entirely from commodity comonomers including 2-ethylhexyl acrylate, fully recover their material properties after damage. BACKGROUND The...
Published: 7/30/2025
|
Inventor(s):
Keywords(s):
Materials
,
Polymer
,
Smart/Fu
n
ctional materials
Category(s):
Physical Scie
n
ces > Materials and Industrial Processes
Multi-Particle System for Capture a
n
d Detection of Cellular and Molecular Analytes (Case No. 2025-267)
Summary: UCLA researchers i
n
the Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 7/29/2025
|
Inventor(s):
Di
n
o Di Carlo
,
Alyssa Ar
n
heim
,
Michael Mellody
,
Yuta
N
akagawa
,
Lily Sha
n
g
Keywords(s):
Assay
,
B Cell
,
barcode
,
Bioassay
,
biological assays
,
Biomarker
,
biomarkers
,
Biomaterial
,
cappi
n
g particles
,
CAR-T cell platform
,
CAR-T cell therapy
,
cavities
,
cavity-co
n
taining particles
,
Cell a
n
d tissue culture
,
cell e
n
capsulation
,
cell e
n
gineering
,
cell imagi
n
g
,
cell mappi
n
g
,
cell sorti
n
g
,
cell type ide
n
tification
,
cell-based therapy
,
ce
n
trifugation
,
co
n
finement
,
Diag
n
ostic Platform Technologies (E.G. Microfluidics)
,
Digital Microfluidics
,
Drug
,
Drug Delivery
,
Drug Discovery
,
drug scree
n
ing
,
high throughput
,
high throughput assays
,
high throughput testi
n
g
,
high-throughput a
n
alysis
,
High-Throughput Scree
n
ing
,
Immu
n
oassay
,
Immu
n
oassay Sense (Molecular Biology)
,
Microfluidics
,
Microfluidics A
n
d Mem's
,
Microfluidics
N
anosphere
,
microparticles
,
moieties
,
N
anoparticle
,
si
n
gle cell analysis
,
si
n
gle cell analysis and testing
,
Si
n
gle cell data
,
si
n
gle-cell resolution
,
si
n
gle-cell trapping
Category(s):
Life Scie
n
ce Research Tools
,
Life Scie
n
ce Research Tools > Cell Counting And Imaging
,
Life Scie
n
ce Research Tools > Lab Equipment
,
Life Scie
n
ce Research Tools > Microscopy And Imaging
,
Life Scie
n
ce Research Tools > Microfluidics And Mems
,
Medical Devices
,
Platforms
Covale
n
t Adaptable Networks with Associative Siloxane Exchange Enabled by Amide-Based Internal Catalysis
N
U2025-056 INVENTORS John Torkelson* Tapas Debsharma Nathan Purwanto Tong Wang SHORT DESCRIPTION A technology that introduces internally catalyzed siloxane dynamic chemistry in covalent adaptable networks (CANs) through amide-based catalysis to produce recyclable and reprocessable polymers with maintained cross-link density at elevated temperatures. BACKGROUND Replacing...
Published: 7/29/2025
|
Inventor(s):
Keywords(s):
Category(s):
Physical Scie
n
ces > Materials and Industrial Processes
Recyclable a
n
d Depolymerizable Polymer Network Materials via Thiourethane Dynamic Chemistry
N
U2019-126 INVENTORS John Torkelson* Lingqiao Li Xi Chen SHORT DESCRIPTION A class of reprocessable, PU-like polymer networks synthesized via thiourethane dynamic chemistry that allow for complete cross-link density recovery and offer the potential for monomer recovery under mild conditions. BACKGROUND Traditional cross-linked polyurethane...
Published: 7/29/2025
|
Inventor(s):
Keywords(s):
Category(s):
Physical Scie
n
ces > Materials and Industrial Processes
Fusio
n
Protein for Development of Transgenic Resistance to Lepidopteran Pests
A Specific, Eco-Frie
n
dly Approach to Pest Control Using Genetically Engineered Biopesticides A fusion protein comprised of a densovirus coat protein, a proline-rich linker, and an insect-specific neurotoxin allows for the development of transgenic crops with resistance to lepidopteran (caterpillar) pests. Insects cause agricultural loss and economic...
Published: 7/31/2025
|
Inventor(s):
Bryo
n
y Bonning
Keywords(s):
Category(s):
Tech
n
ology Classifications > Agricultural > Insect Control
,
Tech
n
ology Classifications > Agricultural > Therapeutics
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