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N
isin Lantibiotic Mitigates Brain Microbiome Dysbiosis and Alzheimer’s Disease-Like Neuroinflammation (UCLA Case No. 2024-096)
Researchers led by Professor Yvo
n
ne Kapila in the UCLA School of Dentistry have developed a technology that harnesses nisin, a well-characterized probiotic lantibiotic bacteriocin, as a novel therapeutic to address brain microbiome dysbiosis and Alzheimer’s disease (AD)-like neuroinflammation driven by periodontal disease. By targeting the microbial...
Published: 9/13/2025
|
Inventor(s):
Yvo
n
ne Kapila
Keywords(s):
Category(s):
Therapeutics > C
N
S and Neurology
POLQ as a Mediator of Radioresista
n
ce in Prostate Cancer (UCLA Case No. 2024-068)
Please co
n
tact UCLA Technology Development Group for more information. KEYWORDS: cancer biology, cancer therapy resistance, molecular oncology, drug discovery, radiosensitization, radioresistance mechanisms, predictive biomarkers, prostate cancer
Published: 9/13/2025
|
Inventor(s):
Paul Boutros
Keywords(s):
Category(s):
Therapeutics > O
n
cology
,
Diag
n
ostic Markers
Cohesive CLEM, TEM, FEBSEM System for MicroED a
n
d Cryo-EM Applications (Case No. 2025-010)
Summary UCLA researchers have developed a cohesive electro
n
microscope system that uniquely integrates transmission electron microscopy (TEM), fluorescence microscopy, and focused ion beam scanning electron microscopy (FIB-SEM) into a single automated column. The platform supports both cryogenic and room-temperature workflows, enabling fully automated...
Published: 9/12/2025
|
Inventor(s):
Tamir Go
n
en
,
Michael Marty
n
owycz
Keywords(s):
Category(s):
Life Scie
n
ce Research Tools
,
Life Scie
n
ce Research Tools > Microscopy And Imaging
,
Life Scie
n
ce Research Tools > Research Methods
,
Medical Devices
,
Medical Devices > Medical Imagi
n
g
,
Platforms
Discrete Approximatio
n
of Permanent Magnet Arrays (Case No. 2025-203)
Summary UCLA researchers have developed Discrete-MAG, a discrete mag
n
etic actuation / magnetics platform that delivers precise, programmable magnetic field manipulation at small scales. The system aims to control magnetic particles or micro-devices discretely for applications in sensing, actuation, imaging, or biological interfacing. Background Magnetic...
Published: 9/12/2025
|
Inventor(s):
Tyler Clites
,
He Kai Lim
,
Will Fla
n
agan
,
Camero
n
Taylor
Keywords(s):
Category(s):
Materials
,
Materials > Fu
n
ctional Materials
,
Medical Devices
,
Mecha
n
ical
,
Mecha
n
ical > Robotics
,
Platforms
,
Platforms > Drug Delivery
,
Medical Devices > Medical Imagi
n
g
,
Life Scie
n
ce Research Tools
,
Life Scie
n
ce Research Tools > Research Methods
Multimeter-Wave Acoustic Reso
n
ators (Case No. 2025-167)
Summary Researchers at the U
n
iversity of Texas System have developed multimeter-wave acoustic resonators using thin-film piezoelectric materials such as lithium niobate / lithium tantalate or aluminum nitride / scandium aluminum nitride, in combination with intermediate buffer layers. These resonators support higher-order antisymmetric bulk acoustic...
Published: 9/12/2025
|
Inventor(s):
Mark Goorsky
,
Ruoche
n
Lu
,
Jack Kramer
,
Si
n
woo Cho
,
Omar Barrera
Keywords(s):
Category(s):
Electrical
,
Electrical > Electro
n
ics & Semiconductors
,
Electrical > Sig
n
al Processing
,
Optics & Photo
n
ics
Methods of Dealke
n
ylative Amination and Azidation (UCLA Case No. 2024-032)
UCLA researchers led by Professor Ohyu
n
Kwon have developed a toolkit for organic synthesis, providing chemists with a robust, selective, and practical solution for the construction of amine and azide functionalities via innovative dealkenylative strategies, opening new avenues in drug discovery and complex molecule assembly. The dealkenylative amination...
Published: 9/12/2025
|
Inventor(s):
Ohyu
n
Kwon
Keywords(s):
Category(s):
Platforms
,
Life Scie
n
ce Research Tools
Structure-Based Desig
n
of Antisense Oligonucleotide Drugs (UCLA Case No. 2020-916)
UCLA researchers led by Professor Fe
n
g Guo have developed a next-generation platform for designing antisense oligonucleotide (ASO) therapeutics using RNA structure as a blueprint, achieving enhanced specificity, efficacy, and versatility for the treatment of a wide spectrum of genetic and infectious diseases. INNOVATION: UCLA researchers in the Department...
Published: 9/12/2025
|
Inventor(s):
Fe
n
g Guo
,
Vaithili
n
garaja Arumugaswami
Keywords(s):
Category(s):
Platforms
,
Therapeutics > I
n
fectious Diseases
,
Therapeutics > Ge
n
etic Diseases
Hess Scree
n
Test Chart Digitalization Tool (Case No. 2024-164)
Summary UCLA researchers have developed a software-based digitizer for Hess Scree
n
Test (HST) charts that automates extraction of gaze misalignment measurements across the visual field, converting paper charts into precise numerical eye-angle data. The system is faster, more repeatable, and more scalable than manual annotation. IOVS Background The...
Published: 9/12/2025
|
Inventor(s):
Qi Wei
,
A
n
drew Ryan
,
Joseph Demer
Keywords(s):
Category(s):
Software & Algorithms
,
Software & Algorithms > Digital Health
,
Software & Algorithms > Image Processi
n
g
,
Medical Devices
,
Medical Devices > Medical Imagi
n
g
,
Medical Devices > Mo
n
itoring And Recording Systems
Self-Assembli
n
g Tetrahedral Protein Cages Based on Machine Learning Algorithms (UCLA Case No. 2023-300)
Please co
n
tact our office for more information regarding this innovation. See also Technology -2020-922 A Universal Designed Protein Cage for Sensing and Responding to Any Other Protein Molecule Related publications (by the inventors only): Gladkov N, Scott EA, Meador K, Lee EJ, Laganowsky AD, Yeates TO, Castells-Graells R. Design of a symmetry-broken...
Published: 9/12/2025
|
Inventor(s):
Todd Yeates
Keywords(s):
Category(s):
Medical Devices
,
Platforms > Drug Delivery
Co
n
struction of Low-Rate LDPC Codes From Rate-½ CCSDS Standard LDPC Codes (Case No. 2025-243)
Refere
n
ce: UCLA Case No. 2025-243. Please reach out to our office for more information.
Published: 9/12/2025
|
Inventor(s):
Richard Wesel
,
Semira Galijasevic
,
Li
n
fang Wang
,
Jo
n
Hamkins
,
Dariush Divsalar
Keywords(s):
Category(s):
Software & Algorithms
,
Software & Algorithms > Commu
n
ication & Networking
,
Software & Algorithms > Security & Privacy
,
Electrical
,
Electrical > Sig
n
al Processing
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