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Pancreas Cancer Immunotherapy using Cationic Lipid and Polymer Nanocarriers
f
or co-delivery of KRAS Neoantigens and STING or other immunomodulators to boost the Cancer Immunity Cycle and Treat Liver Metastasis (UCLA Case No. 2024-076)
UCLA researchers have developed a translational immunotherapy plat
f
orm that leverages nanoparticle-based delivery of tumor-associated signals and immune-stimulatory molecules to drive localized immune activation in metastatic pancreatic cancer. This approach is designed to initiate de novo immune priming and recondition the tumor microenvironment in...
Published: 10/29/2025
|
Inventor(s):
Andre Nel
Keywords(s):
Category(s):
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
,
Therapeutics > Vaccines
,
Plat
f
orms > Drug Delivery
Novel Adsorbent
f
or Wastewater Treatment and Metal Recovery
Invention Description Heavy metals are non-biodegradable and can contaminate in ecosystems and the
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ood chain, making them one of the most pressing environmental issues of our time. Certain industrial practices have resulted in an increase in the amount of heavy metals discharged into wastewater which can then leach into or contaminate other water...
Published: 10/29/2025
|
Inventor(s):
Elham
F
ini
,
F
arideh Pahlavan
Keywords(s):
Category(s):
Advanced Materials/Nanotechnology
,
Environmental
,
Environmental Remediation/Wastewater Treatment
,
Physical Science
Uni
f
ied Model of Alzheimer’s Disease Pathobiology
Invention Description Understanding o
f
the pathobiology of Alzheimer’s disease (AD) has long been fragmented, with much research centered around biological mechanisms including amyloid β or tau proteins, inflammation, cell death pathways, glia, mitochondria and more. While these all deal with real facets in the biology of AD, they are limited...
Published: 10/29/2025
|
Inventor(s):
Carol Huseby
,
Elaine Delvaux
,
Paul Coleman
Keywords(s):
Category(s):
Diagnostic Assays/Devices
,
Li
f
e Science (All LS Techs)
,
Medical Diagnostics/Sensors
,
Neurodegenerative Disease Technologies
,
Pharmaceuticals
Non-Destructive Material Characterization o
f
Crystalline Silicon Solar Photovoltaic Panels
Invention Description Crystalline silicon (c-Si) photovoltaic (PV) panels contain a mix o
f
bulk materials (such as glass, silicon, and aluminum), toxic substances (like lead, tin, and copper), and precious metals. Due to solar panel designs not being standardized, their compositions vary. Panels with lead-based solder, for example, contain more lead...
Published: 10/29/2025
|
Inventor(s):
Dwarak Ravikumar
Keywords(s):
Category(s):
Applied Technologies
,
Environmental
,
Physical Science
,
Manu
f
acturing/Construction/Mechanical
Histone H1 as a Therapeutic Target
f
or Fibrosis (UCLA Case No. 2023-148)
UCLA researchers
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rom the David Geffen School of Medicine have identified linker histone H1 as a critical regulator of pathologic gene expression and cellular mechanics, establishing its potential role as a therapeutic target for the treatment of fibrosis. BACKGROUND: Heart failure affects ~6 million Americans and has a 5-year survival rate of ~50%...
Published: 10/29/2025
|
Inventor(s):
Thomas Vondriska
Keywords(s):
Category(s):
Therapeutics > Cardiovascular
Electronic-Photonic Quadrature Delay-Locked Oscillator (DLO)
F
or Efficient High-Speed Clock Generation And Distribution
A Quadrature Delay-Locked Oscillator that caters to increasing multi-GHz and multi-phase clock demands in systems such as time-interleaved architectures. Problem: The unrelenting growth o
f
artificial intelligence (AI) requires advancements in high-performance hardware capable of delivering high-speed clock generation and distribution. These improvements...
Published: 10/29/2025
|
Inventor(s):
F
irooz Aflatouni
,
Henry Love
Keywords(s):
Arti
f
icial Intelligence (AI) & Machine Learning
,
Electronic Materials
,
Optics & Photonics
Category(s):
Technology Classi
f
ications > Computer Information Systems
,
Technology Classi
f
ications > Hardware & Components
Ready
f
or Tonsillectomy Mobile App
Application A child-
f
riendly mobile application designed to educate children and caregivers on the purpose of tonsillectomies and guide them through pre-, intra-, and post-operative care using age-appropriate, interactive content. Key Benefits The app is interactive and provides education at a child’s literacy level. Market Summary Tonsillectomies...
Published: 10/29/2025
|
Inventor(s):
Holly Cordray
,
Nikhila Raol
,
Kara Prickett
Keywords(s):
Healthcare Pro
f
essional Education and Training
,
Mobile Apps
,
Pediatrics
Category(s):
TechPub Algolia > So
f
tware
Synthetic Peptide Antigens to Detect Anti-Nephrin Autoantibodies
NU2025-147 Inventors Jing Jin* Pan Liu Short Description The invention provides a method
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or detecting anti-nephrin autoantibodies implicated in kidney diseases like minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). This method employs synthetic peptide antigens for use as a clinical diagnostic. Background Kidney...
Published: 10/28/2025
|
Inventor(s):
Keywords(s):
Category(s):
Li
f
e Sciences > Biomarkers & Biomedical Research Tools
Precision DNA PCR-based Assay
f
or Gardnerella vaginalis species in bacterial vaginosis
PAGE TITLE Overview PAGE SUMMARY This new PCR-based companion diagnostic assay leverages genetic analysis to identi
f
y specific members of the Gardnerella vaginalis species and detects resistance to metronidazole, the current first-line treatment for bacterial vaginosis (BV). BV is a prevalent vaginal infection with ~30% annual incidence, high recurrence...
Published: 10/28/2025
|
Inventor(s):
Garth Ehrlich
,
Katherine Innamorati
,
Joshua Earl
Keywords(s):
Category(s):
Medical Devices, Diagnostics & Biosensors
Highly-Sensitive Point-o
f
-Care Diagnostics & Disease Monitoring
Description This technology is a novel, highly-sensitive plat
f
orm to diagnose and monitor diseases in real time at a doctor’s office. Many chronic diseases like cancer and IBD do not have initial screening tests and solely rely on invasive, uncomfortable and time-consuming procedures (like biopsies and colonoscopies). Having a less invasive...
Published: 10/28/2025
|
Inventor(s):
A. G. Unil Perera
,
Mathes Dayananda
,
Hemendra Ghimire
,
Mehmood Piarzada
Keywords(s):
Category(s):
Assay
,
Device
,
Diagnostic
,
Imaging
,
Research Tool
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