Search Results - process

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INV-24009 Background The ability to precisely control molecular orientation in polymer films is critical for optimizing material properties like strength and flexibility in many industrial applications. However, current manufacturing methods rely on applying extensional flow just once during polymerization, limiting orientation control to polymers...

Published: 6/11/2025 | Inventor(s): Steven Lustig, John Biswakarma, Emil Sandoz-Rosado, Andrew Carr, Eric Wetzel

Keywords(s): 2D materials, Coater, Extensional Flow, Polymer, Process, Reactor

Category(s): Technology Classifications > 1. Life Science

Process for Practical, Scalable, Commercially-viable Method for the Synthesis of Enantio-enriched Aminoalcohols, Including the Novel Antifungal VT-1129 Used to Treat Cryptococcal Meningitis

This technology relates to the discovery and development of a practical, scalable, and commercially viable method for the synthesis of the novel antifungal VT-1129. Cryptococcal meningitis (CM) is a fungal infection that is particularly prevalent in immune-compromised patients and can be treated by VT-1129. CM has a current estimated patient population...

Published: 10/28/2024 | Inventor(s): Mark Behnke, Scott David, Douglas Fry, William Hoekstra, Christopher Yates, Asaf Alimardanov

Keywords(s): Acid, Alcohol, Aminoalcohols, Benzenesulfonic, BSA., Co-crystal, Containing, Derivatives, Enantioenriched, Fragment, Including, Listed LPM Nguyen-Antczak as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PROCESS, Synthesis, Tertiary, THOSE, VEXXXX, VT-1129, WMXXXX

Category(s): Application > Consumer Products, TherapeuticArea > Neurology

Ultrasonic in situ Respirator Seal-Leakage Detection with Real-time Feedback Capabilities

This CDC invention entails methods and apparatuses for in situ testing seal integrity and improved operation of respiratory masks (respirators). A variety of external factors, such as individual face shape, user environment, mask age and material used to construct the respirator, can lead to device malfunction and failure to sufficiently protect a...

Published: 4/18/2025 | Inventor(s): Jonathan Szalajda, William King

Keywords(s): AE2XXX, AE3XXX, AEROSOL, AEROSOLS, AEXXXX, AXXXXX, Biodefense, CDC Docket Import, CDC Docket Import CDC Prosecuting, DEVICE, Devices, MASK, NIOSH-NPPTL, Preventative, PROCESS, Protection, Respirator, respiratory, SAFETY, Situ, TESTING, ultrasonic, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WCXXXX, WEXXXX, WFXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XIXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Non-Medical Devices, Application > Medical Devices, TherapeuticArea > Oncology, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Occupational Safety and Health, Application > Research Materials, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Cardiology

Improved Protein Quantification Process and Vaccine Quality Control Production

This CDC invention is a method for identifying and quantifying a group of proteins in a complex mixture by a liquid chromatography-tandem mass spectrometry assay. The technology was developed for influenza although it can be used for a wide variety of protein quantification applications. As specifically developed, conserved peptides from the proteins...

Published: 5/9/2025 | Inventor(s): James Pirkle, Ruben Donis, Leah Luna, Zhu Guo, John Barr, Tracie Williams

Keywords(s): AA2XXX, AA5XXX, AA6XXX, AG2XXX, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, CONTROL, DA4BXX, DA4XXX, DAXXXX, DDXXXX, DXXXXX, Improved, PROCESS, Protein, Quality, QUANTIFICATION, Therewith, Vaccine, viral, VJXXXX, VKXXXX, VLXXXX, WBXXXX, WFXXXX, WHXXXX, WIXXXX, WMXXXX, XCXXXX, XHXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Research Materials, Application > Diagnostics, ResearchProducts > Research Equipment, Application > Occupational Safety and Health

Rapid Detection of Multi-Drug-Resistant Mycobacterium tuberculosis Using Real-Time PCR and High-Resolution Melt Analysis

CDC scientists have developed a rapid, sensitive, and specific real-time PCR assay that is capable of detecting the presence of Mycobacterium tuberculosis and determining its resistance profile to antibiotics, such as rifampicin and isoniazid. Currently, there are few assays available that are capable of both detecting M. tuberculosis and determining...

Published: 5/9/2025 | Inventor(s): Jonas Winchell, Kelley Cowart, Melissa Ramirez, James Posey

Keywords(s): analysis, DA3XXX, DAXXXX, Detection, DXXXXX, High, Melt, Multidrug, PCR, PROCESS, REAL-TIME, RESISTANT, RESOLUTION, TUBERCULOSIS, Tuberculosis (Mycobacterium tuberculosis)

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics

Consistent and enhanced production of anti-cancer drugs from the Madagascar periwinkle plant

INV-19070 Background The Madagascar periwinkle plant has been used for vinblastine (VBL) and vincristine (VCR) since the 1960s. These chemical compounds have been listed on “World Health Organization’s Model List of Essential Medicines”. However, due to high cost, low concentration in extracts, and unpredictable supply, the applications...

Published: 1/29/2025 | Inventor(s): Carolyn Lee-Parsons, Elisa Peter, Samuel Mortensen

Keywords(s): Agriculture/Horticulture, Chemotherapy, Manufacturing, Process, Renewable

Category(s): Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Green Chemistry, Technology Classifications > 1. Life Science > Drug Discovery, Technology Classifications > 1. Life Science > Chemistry

NU/Soleeva: Novel cost-effective high-efficient solar-driven water desalination device

INV-21007 Background Solar energy is now emerging as one of the most promising sustainable energy sources, as it is clean and can be supplied without any environmental pollution compared with other forms of energy. Abundant solar energy makes solar-driven evaporation a promising approach for water desalination and purification. In a conventional solar-driven...

Published: 9/10/2024 | Inventor(s): Yi Zheng, Ralph Ahlgren, Xiaojie Liu, Yanpei Tian, Mohamed Sonbaty, Khushnood Ahmad Qazi

Keywords(s): drinkable water, economizer, high-rate evaporation, interfacial structure, potable water, Process, scalable, solar driven evaporation device, unit cost, water desalination and purification

Category(s): Not in use > -Energy Technology

Sentinel Cell

Sentry Cell (Macrophage Hazardous Material Detection) WSU Tech#: 10-991 Technology Summary: This technology is designed around an isolated cell system for the detection of an energetic material comprising of an isolated stationary macrophage cell isolated from a vestibular labyrinth of a Opsanus sp. This macrophage cell is plated in...

Published: 1/9/2023 | Inventor(s): Robert Silver

Keywords(s): Imaging, Process, Research Tool

Category(s): Process/Procedure, Biotechnology, Environment, Safety

Method and Device for Drug Discovery

INV-1253 Background Historically, natural products and microorganisms have been considered as the major sources of new pharmaceutical compounds. However, in recent years, there has been a dramatic drop in natural-based drug discovery from big pharmaceutical companies. The major challenges are the prevailing paradigm for drug discovery in large pharmaceutical...

Published: 9/10/2024 | Inventor(s): Slava Epstein

Keywords(s): Analytical Chemistry, Biotech, Drug Discovery & Development, Infectious Disease (including AIDS), Process, Research Tool

Category(s): Technology Classifications > 2. Physical Science > Lab tech/equipment, Technology Classifications > 1. Life Science > Drug Discovery, Not in use > -Microbiology, Not in use > -Health, Not in use > -Analytical Chemistry

Method for Delivery to the Brain of Plasmid DNA Encoding Therapeutic Proteins for CNS Disorders

#0000FF;text-decoration: underline;border-collapse: collapse; } INV-1262 Background Neurodegenerative diseases are debilitating diseases that impose significant financial and social impact and burden. The prevalence of these diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, is progressing...

Published: 9/10/2024 | Inventor(s): Barbara Waszczak, Brendan Harmon, Mark Cooper

Keywords(s): Biology, Biotech, Chemistry, Drug Delivery, Health, Medical, Medical/Health, Method, Neurological Disease, Process, Psychiatric Disease, Therapeutic

Category(s): Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Delivery, Not in use > -Biology, Not in use > -Health