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ID
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Quinoline-derived
S
ARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demon
s
trates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Praka
s
h Jadhav
,
Bin Tan
,
Haozhou Tan
Keywords(s):
Antiviral
Category(s):
Technology Cla
s
sifications > COVID-19
,
Technology Cla
s
sifications > Healthcare & Life Sciences
,
Technology Cla
s
sifications > Infectious Disease
,
Technology Cla
s
sifications > Therapeutics
S
pecific inhibitors to mitigate mu opioid‐induced side‐effects without compromising analgesia
Preliminary data
s
hows that the inhibitor significantly mitigates morphine tolerance in a mouse study Invention Summary: Mu opioids such as morphine and fentanyl are commonly used for pain management but can lead to tolerance, addiction, and opioid use disorder. Current therapeutic solutions for these adverse conditions include buprenorphine,...
Published: 7/31/2025
|
Inventor(s):
Yingxian Pan
Keywords(s):
Category(s):
Technology Cla
s
sifications > Healthcare & Life Sciences
,
Technology Cla
s
sifications
,
Technology Cla
s
sifications > Therapeutics
Method for Optimizing an Integrated Flight Control
S
ystem using Reinforcement Meta-Learning
Thi
s
technology is a method to incorporate reinforcement meta-learning to the design of a flight control system for missiles. The integration will benefit the control system, as it optimizes it with the help of a simulation environment. The technology removes the need for manual tuning of the control system settings. Background: The flight control...
Published: 7/30/2025
|
Inventor(s):
Roberto Furfaro
,
Brian Gaudet
Keywords(s):
Category(s):
Technology Cla
s
sifications > Software & Information Technology
,
Technology Cla
s
sifications > Engineering & Physical Sciences > Aerospace Engineering
TRP: A Mou
s
e Model of Limb Girdle Muscular Dystrophy Type 2A (R1/D4) (UCLA Case No. 2021-171)
UCLA re
s
earchers in the Department of Neurology have developed a novel mouse model for limb girdle muscular dystrophy, a disorder that causes muscle weakness in the limbs and hip area. BACKGROUND: Limb-Girdle Muscular Dystrophy Type 2A (LGMDR1) is a genetic neuromuscular disorder characterized by progressive muscle weakness, primarily affecting muscles...
Published: 7/30/2025
|
Inventor(s):
Meli
s
sa Spencer
Keywords(s):
Category(s):
Life
S
cience Research Tools > Animal Models
Regio
s
elective 1,2-Dearomatization of Functionalized Azines by Organolanthanide Catalysts
NU2014-129 INVENTOR
S
Tobin Marks* Alexander Dudnik Massimiliano Delferro Victoria Weidner SHORT DESCRIPTION This invention describes a catalytic process for the regioselective 1,2-dearomatization of functionalized azines using an organolanthanide catalyst and pinacolborane (HBpin). It offers a streamlined approach to key intermediates for pharmaceuticals...
Published: 7/30/2025
|
Inventor(s):
Keywords(s):
Cataly
s
t
,
Chemical
s
,
Manufacturing/Proce
s
sing
,
Material
s
Category(s):
Phy
s
ical Sciences > Materials and Industrial Processes
Novel
s
elf-healing commodity copolymers based on 2-ethylhexyl acrylate
NU2023-240 INVENTOR
S
John Torkelson* Tong Wang SHORT DESCRIPTION This invention describes a new class of random copolymers that exhibit autonomous self-healing behavior at room temperature. The copolymers, derived entirely from commodity comonomers including 2-ethylhexyl acrylate, fully recover their material properties after damage. BACKGROUND The...
Published: 7/30/2025
|
Inventor(s):
Keywords(s):
Material
s
,
Polymer
,
S
mart/Functional materials
Category(s):
Phy
s
ical Sciences > Materials and Industrial Processes
Multi-Particle
S
ystem for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)
S
ummary: UCLA researchers in the Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 7/29/2025
|
Inventor(s):
Dino Di Carlo
,
Aly
s
sa Arnheim
,
Michael Mellody
,
Yuta Nakagawa
,
Lily
S
hang
Keywords(s):
A
s
say
,
B Cell
,
barcode
,
Bioa
s
say
,
biological a
s
says
,
Biomarker
,
biomarker
s
,
Biomaterial
,
capping particle
s
,
CAR-T cell platform
,
CAR-T cell therapy
,
cavitie
s
,
cavity-containing particle
s
,
Cell and ti
s
sue culture
,
cell encap
s
ulation
,
cell engineering
,
cell imaging
,
cell mapping
,
cell
s
orting
,
cell type identification
,
cell-ba
s
ed therapy
,
centrifugation
,
confinement
,
Diagno
s
tic Platform Technologies (E.G. Microfluidics)
,
Digital Microfluidic
s
,
Drug
,
Drug Delivery
,
Drug Di
s
covery
,
drug
s
creening
,
high throughput
,
high throughput a
s
says
,
high throughput te
s
ting
,
high-throughput analy
s
is
,
High-Throughput
S
creening
,
Immunoa
s
say
,
Immunoa
s
say Sense (Molecular Biology)
,
Microfluidic
s
,
Microfluidic
s
And Mem's
,
Microfluidic
s
Nanosphere
,
microparticle
s
,
moietie
s
,
Nanoparticle
,
s
ingle cell analysis
,
s
ingle cell analysis and testing
,
S
ingle cell data
,
s
ingle-cell resolution
,
s
ingle-cell trapping
Category(s):
Life
S
cience Research Tools
,
Life
S
cience Research Tools > Cell Counting And Imaging
,
Life
S
cience Research Tools > Lab Equipment
,
Life
S
cience Research Tools > Microscopy And Imaging
,
Life
S
cience Research Tools > Microfluidics And Mems
,
Medical Device
s
,
Platform
s
Covalent Adaptable Network
s
with Associative Siloxane Exchange Enabled by Amide-Based Internal Catalysis
NU2025-056 INVENTOR
S
John Torkelson* Tapas Debsharma Nathan Purwanto Tong Wang SHORT DESCRIPTION A technology that introduces internally catalyzed siloxane dynamic chemistry in covalent adaptable networks (CANs) through amide-based catalysis to produce recyclable and reprocessable polymers with maintained cross-link density at elevated temperatures. BACKGROUND Replacing...
Published: 7/29/2025
|
Inventor(s):
Keywords(s):
Category(s):
Phy
s
ical Sciences > Materials and Industrial Processes
Recyclable and Depolymerizable Polymer Network Material
s
via Thiourethane Dynamic Chemistry
NU2019-126 INVENTOR
S
John Torkelson* Lingqiao Li Xi Chen SHORT DESCRIPTION A class of reprocessable, PU-like polymer networks synthesized via thiourethane dynamic chemistry that allow for complete cross-link density recovery and offer the potential for monomer recovery under mild conditions. BACKGROUND Traditional cross-linked polyurethane...
Published: 7/29/2025
|
Inventor(s):
Keywords(s):
Category(s):
Phy
s
ical Sciences > Materials and Industrial Processes
Fu
s
ion Protein for Development of Transgenic Resistance to Lepidopteran Pests
A
S
pecific, Eco-Friendly Approach to Pest Control Using Genetically Engineered Biopesticides A fusion protein comprised of a densovirus coat protein, a proline-rich linker, and an insect-specific neurotoxin allows for the development of transgenic crops with resistance to lepidopteran (caterpillar) pests. Insects cause agricultural loss and economic...
Published: 7/31/2025
|
Inventor(s):
Bryony Bonning
Keywords(s):
Category(s):
Technology Cla
s
sifications > Agricultural > Insect Control
,
Technology Cla
s
sifications > Agricultural > Therapeutics
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