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Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
A lead co
m
pound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Prakash Jadhav
,
Bin Tan
,
Haozhou Tan
Keywords(s):
Antiviral
Category(s):
Technology Classifications > COVID-19
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
Specific inhibitors to
m
itigate mu opioid‐induced side‐effects without compromising analgesia
Preli
m
inary data shows that the inhibitor significantly mitigates morphine tolerance in a mouse study Invention Summary: Mu opioids such as morphine and fentanyl are commonly used for pain management but can lead to tolerance, addiction, and opioid use disorder. Current therapeutic solutions for these adverse conditions include buprenorphine,...
Published: 7/31/2025
|
Inventor(s):
Yingxian Pan
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications
,
Technology Classifications > Therapeutics
M
ethod for Optimizing an Integrated Flight Control System using Reinforcement Meta-Learning
This technology is a
m
ethod to incorporate reinforcement meta-learning to the design of a flight control system for missiles. The integration will benefit the control system, as it optimizes it with the help of a simulation environment. The technology removes the need for manual tuning of the control system settings. Background: The flight control...
Published: 7/30/2025
|
Inventor(s):
Roberto Furfaro
,
Brian Gaudet
Keywords(s):
Category(s):
Technology Classifications > Software & Infor
m
ation Technology
,
Technology Classifications > Engineering & Physical Sciences > Aerospace Engineering
TRP: A
M
ouse Model of Limb Girdle Muscular Dystrophy Type 2A (R1/D4) (UCLA Case No. 2021-171)
UCLA researchers in the Depart
m
ent of Neurology have developed a novel mouse model for limb girdle muscular dystrophy, a disorder that causes muscle weakness in the limbs and hip area. BACKGROUND: Limb-Girdle Muscular Dystrophy Type 2A (LGMDR1) is a genetic neuromuscular disorder characterized by progressive muscle weakness, primarily affecting muscles...
Published: 7/30/2025
|
Inventor(s):
M
elissa Spencer
Keywords(s):
Category(s):
Life Science Research Tools > Ani
m
al Models
Regioselective 1,2-Dearo
m
atization of Functionalized Azines by Organolanthanide Catalysts
NU2014-129 INVENTORS Tobin
M
arks* Alexander Dudnik Massimiliano Delferro Victoria Weidner SHORT DESCRIPTION This invention describes a catalytic process for the regioselective 1,2-dearomatization of functionalized azines using an organolanthanide catalyst and pinacolborane (HBpin). It offers a streamlined approach to key intermediates for pharmaceuticals...
Published: 7/30/2025
|
Inventor(s):
Keywords(s):
Catalyst
,
Che
m
icals
,
M
anufacturing/Processing
,
M
aterials
Category(s):
Physical Sciences >
M
aterials and Industrial Processes
Novel self-healing co
m
modity copolymers based on 2-ethylhexyl acrylate
NU2023-240 INVENTORS John Torkelson* Tong Wang SHORT DESCRIPTION This invention describes a new class of rando
m
copolymers that exhibit autonomous self-healing behavior at room temperature. The copolymers, derived entirely from commodity comonomers including 2-ethylhexyl acrylate, fully recover their material properties after damage. BACKGROUND The...
Published: 7/30/2025
|
Inventor(s):
Keywords(s):
M
aterials
,
Poly
m
er
,
S
m
art/Functional materials
Category(s):
Physical Sciences >
M
aterials and Industrial Processes
M
ulti-Particle System for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)
Su
m
mary: UCLA researchers in the Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 7/29/2025
|
Inventor(s):
Dino Di Carlo
,
Alyssa Arnhei
m
,
M
ichael Mellody
,
Yuta Nakagawa
,
Lily Shang
Keywords(s):
Assay
,
B Cell
,
barcode
,
Bioassay
,
biological assays
,
Bio
m
arker
,
bio
m
arkers
,
Bio
m
aterial
,
capping particles
,
CAR-T cell platfor
m
,
CAR-T cell therapy
,
cavities
,
cavity-containing particles
,
Cell and tissue culture
,
cell encapsulation
,
cell engineering
,
cell i
m
aging
,
cell
m
apping
,
cell sorting
,
cell type identification
,
cell-based therapy
,
centrifugation
,
confine
m
ent
,
Diagnostic Platfor
m
Technologies (E.G. Microfluidics)
,
Digital
M
icrofluidics
,
Drug
,
Drug Delivery
,
Drug Discovery
,
drug screening
,
high throughput
,
high throughput assays
,
high throughput testing
,
high-throughput analysis
,
High-Throughput Screening
,
I
m
munoassay
,
I
m
munoassay Sense (Molecular Biology)
,
M
icrofluidics
,
M
icrofluidics And Mem's
,
M
icrofluidics Nanosphere
,
m
icroparticles
,
m
oieties
,
Nanoparticle
,
single cell analysis
,
single cell analysis and testing
,
Single cell data
,
single-cell resolution
,
single-cell trapping
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Cell Counting And I
m
aging
,
Life Science Research Tools > Lab Equip
m
ent
,
Life Science Research Tools >
M
icroscopy And Imaging
,
Life Science Research Tools >
M
icrofluidics And Mems
,
M
edical Devices
,
Platfor
m
s
Covalent Adaptable Networks with Associative Siloxane Exchange Enabled by A
m
ide-Based Internal Catalysis
NU2025-056 INVENTORS John Torkelson* Tapas Debshar
m
a Nathan Purwanto Tong Wang SHORT DESCRIPTION A technology that introduces internally catalyzed siloxane dynamic chemistry in covalent adaptable networks (CANs) through amide-based catalysis to produce recyclable and reprocessable polymers with maintained cross-link density at elevated temperatures. BACKGROUND Replacing...
Published: 7/29/2025
|
Inventor(s):
Keywords(s):
Category(s):
Physical Sciences >
M
aterials and Industrial Processes
Recyclable and Depoly
m
erizable Polymer Network Materials via Thiourethane Dynamic Chemistry
NU2019-126 INVENTORS John Torkelson* Lingqiao Li Xi Chen SHORT DESCRIPTION A class of reprocessable, PU-like poly
m
er networks synthesized via thiourethane dynamic chemistry that allow for complete cross-link density recovery and offer the potential for monomer recovery under mild conditions. BACKGROUND Traditional cross-linked polyurethane...
Published: 7/29/2025
|
Inventor(s):
Keywords(s):
Category(s):
Physical Sciences >
M
aterials and Industrial Processes
Fusion Protein for Develop
m
ent of Transgenic Resistance to Lepidopteran Pests
A Specific, Eco-Friendly Approach to Pest Control Using Genetically Engineered Biopesticides A fusion protein co
m
prised of a densovirus coat protein, a proline-rich linker, and an insect-specific neurotoxin allows for the development of transgenic crops with resistance to lepidopteran (caterpillar) pests. Insects cause agricultural loss and economic...
Published: 7/31/2025
|
Inventor(s):
Bryony Bonning
Keywords(s):
Category(s):
Technology Classifications > Agricultural > Insect Control
,
Technology Classifications > Agricultural > Therapeutics
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