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Nisin Lantibiotic
M
itigates Brain Microbiome Dysbiosis and Alzheimer’s Disease-Like Neuroinflammation (UCLA Case No. 2024-096)
Researchers led by Professor Yvonne Kapila in the UCLA School of Dentistry have developed a technology that harnesses nisin, a well-characterized probiotic lantibiotic bacteriocin, as a novel therapeutic to address brain
m
icrobiome dysbiosis and Alzheimer’s disease (AD)-like neuroinflammation driven by periodontal disease. By targeting the microbial...
Published: 9/13/2025
|
Inventor(s):
Yvonne Kapila
Keywords(s):
Category(s):
Therapeutics > CNS and Neurology
POLQ as a
M
ediator of Radioresistance in Prostate Cancer (UCLA Case No. 2024-068)
Please contact UCLA Technology Develop
m
ent Group for more information. KEYWORDS: cancer biology, cancer therapy resistance, molecular oncology, drug discovery, radiosensitization, radioresistance mechanisms, predictive biomarkers, prostate cancer
Published: 9/13/2025
|
Inventor(s):
Paul Boutros
Keywords(s):
Category(s):
Therapeutics > Oncology
,
Diagnostic
M
arkers
Cohesive CLE
M
, TEM, FEBSEM System for MicroED and Cryo-EM Applications (Case No. 2025-010)
Su
m
mary UCLA researchers have developed a cohesive electron microscope system that uniquely integrates transmission electron microscopy (TEM), fluorescence microscopy, and focused ion beam scanning electron microscopy (FIB-SEM) into a single automated column. The platform supports both cryogenic and room-temperature workflows, enabling fully automated...
Published: 9/12/2025
|
Inventor(s):
Ta
m
ir Gonen
,
M
ichael Martynowycz
Keywords(s):
Category(s):
Life Science Research Tools
,
Life Science Research Tools >
M
icroscopy And Imaging
,
Life Science Research Tools > Research
M
ethods
,
M
edical Devices
,
M
edical Devices > Medical Imaging
,
Platfor
m
s
Discrete Approxi
m
ation of Permanent Magnet Arrays (Case No. 2025-203)
Su
m
mary UCLA researchers have developed Discrete-MAG, a discrete magnetic actuation / magnetics platform that delivers precise, programmable magnetic field manipulation at small scales. The system aims to control magnetic particles or micro-devices discretely for applications in sensing, actuation, imaging, or biological interfacing. Background Magnetic...
Published: 9/12/2025
|
Inventor(s):
Tyler Clites
,
He Kai Li
m
,
Will Flanagan
,
Ca
m
eron Taylor
Keywords(s):
Category(s):
M
aterials
,
M
aterials > Functional Materials
,
M
edical Devices
,
M
echanical
,
M
echanical > Robotics
,
Platfor
m
s
,
Platfor
m
s > Drug Delivery
,
M
edical Devices > Medical Imaging
,
Life Science Research Tools
,
Life Science Research Tools > Research
M
ethods
M
ultimeter-Wave Acoustic Resonators (Case No. 2025-167)
Su
m
mary Researchers at the University of Texas System have developed multimeter-wave acoustic resonators using thin-film piezoelectric materials such as lithium niobate / lithium tantalate or aluminum nitride / scandium aluminum nitride, in combination with intermediate buffer layers. These resonators support higher-order antisymmetric bulk acoustic...
Published: 9/12/2025
|
Inventor(s):
M
ark Goorsky
,
Ruochen Lu
,
Jack Kra
m
er
,
Sinwoo Cho
,
O
m
ar Barrera
Keywords(s):
Category(s):
Electrical
,
Electrical > Electronics & Se
m
iconductors
,
Electrical > Signal Processing
,
Optics & Photonics
M
ethods of Dealkenylative Amination and Azidation (UCLA Case No. 2024-032)
UCLA researchers led by Professor Ohyun Kwon have developed a toolkit for organic synthesis, providing che
m
ists with a robust, selective, and practical solution for the construction of amine and azide functionalities via innovative dealkenylative strategies, opening new avenues in drug discovery and complex molecule assembly. The dealkenylative amination...
Published: 9/12/2025
|
Inventor(s):
Ohyun Kwon
Keywords(s):
Category(s):
Platfor
m
s
,
Life Science Research Tools
Structure-Based Design of Antisense Oligonucleotide Drugs (UCLA Case No. 2020-916)
UCLA researchers led by Professor Feng Guo have developed a next-generation platfor
m
for designing antisense oligonucleotide (ASO) therapeutics using RNA structure as a blueprint, achieving enhanced specificity, efficacy, and versatility for the treatment of a wide spectrum of genetic and infectious diseases. INNOVATION: UCLA researchers in the Department...
Published: 9/12/2025
|
Inventor(s):
Feng Guo
,
Vaithilingaraja Aru
m
ugaswami
Keywords(s):
Category(s):
Platfor
m
s
,
Therapeutics > Infectious Diseases
,
Therapeutics > Genetic Diseases
Hess Screen Test Chart Digitalization Tool (Case No. 2024-164)
Su
m
mary UCLA researchers have developed a software-based digitizer for Hess Screen Test (HST) charts that automates extraction of gaze misalignment measurements across the visual field, converting paper charts into precise numerical eye-angle data. The system is faster, more repeatable, and more scalable than manual annotation. IOVS Background The...
Published: 9/12/2025
|
Inventor(s):
Qi Wei
,
Andrew Ryan
,
Joseph De
m
er
Keywords(s):
Category(s):
Software & Algorith
m
s
,
Software & Algorith
m
s > Digital Health
,
Software & Algorith
m
s > Image Processing
,
M
edical Devices
,
M
edical Devices > Medical Imaging
,
M
edical Devices > Monitoring And Recording Systems
Self-Asse
m
bling Tetrahedral Protein Cages Based on Machine Learning Algorithms (UCLA Case No. 2023-300)
Please contact our office for
m
ore information regarding this innovation. See also Technology -2020-922 A Universal Designed Protein Cage for Sensing and Responding to Any Other Protein Molecule Related publications (by the inventors only): Gladkov N, Scott EA, Meador K, Lee EJ, Laganowsky AD, Yeates TO, Castells-Graells R. Design of a symmetry-broken...
Published: 9/12/2025
|
Inventor(s):
Todd Yeates
Keywords(s):
Category(s):
M
edical Devices
,
Platfor
m
s > Drug Delivery
Construction of Low-Rate LDPC Codes Fro
m
Rate-½ CCSDS Standard LDPC Codes (Case No. 2025-243)
Reference: UCLA Case No. 2025-243. Please reach out to our office for
m
ore information.
Published: 9/12/2025
|
Inventor(s):
Richard Wesel
,
Se
m
ira Galijasevic
,
Linfang Wang
,
Jon Ha
m
kins
,
Dariush Divsalar
Keywords(s):
Category(s):
Software & Algorith
m
s
,
Software & Algorith
m
s > Communication & Networking
,
Software & Algorith
m
s > Security & Privacy
,
Electrical
,
Electrical > Signal Processing
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